Abstract：
:The Clock mutation lengthens periodicity and reduces amplitude of circadian rhythms in mice. The effects of Clock are cell intrinsic and can be observed at the level of single neurons in the suprachiasmatic nucleus. To address how cells of contrasting genotype functionally interact in vivo to control circadian behavior, we have analyzed a series of Clock mutant mouse aggregation chimeras. Circadian behavior in Clock/Clock <--> wild-type chimeric individuals was determined by the proportion of mutant versus normal cells. Significantly, a number of intermediate phenotypes, including Clock/+ phenocopies and novel combinations of the parental behavioral characteristics, were seen in balanced chimeras. Multivariate statistical techniques were used to quantitatively analyze relationships among circadian period, amplitude, and suprachiasmatic nucleus composition. Together, our results demonstrate that complex integration of cellular phenotypes determines the generation and expression of coherent circadian rhythms at the organismal level.
journal_name
Celljournal_title
Cellauthors
Low-Zeddies SS,Takahashi JSdoi
10.1016/s0092-8674(01)00294-xsubject
Has Abstractpub_date
2001-04-06 00:00:00pages
25-42issue
1eissn
0092-8674issn
1097-4172pii
S0092-8674(01)00294-Xjournal_volume
105pub_type
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