Abstract:
:Cyclic dinucleotides (CDNs) have been previously recognized as important secondary signaling molecules in bacteria and, more recently, in mammalian cells. In the former case, they represent secondary messengers affecting numerous responses of the prokaryotic cell, whereas in the latter, they act as agonists of the innate immune response. Remarkable new discoveries have linked these two patterns of utilization of CDNs as secondary messengers and have revealed unexpected influences they likely had on shaping human genetic variation. This Review summarizes these recent insights and provides a perspective on future unanswered questions in this exciting field.
journal_name
Celljournal_title
Cellauthors
Danilchanka O,Mekalanos JJdoi
10.1016/j.cell.2013.08.014subject
Has Abstractpub_date
2013-08-29 00:00:00pages
962-970issue
5eissn
0092-8674issn
1097-4172pii
S0092-8674(13)01008-8journal_volume
154pub_type
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