Abstract：
:Microbial populations can maximize fitness in dynamic environments through bet hedging, a process wherein a subpopulation assumes a phenotype not optimally adapted to the present environment but well adapted to an environment likely to be encountered. Here, we show that oxygen induces fluctuating expression of the trimethylamine oxide (TMAO) respiratory system of Escherichia coli, diversifying the cell population and enabling a bet-hedging strategy that permits growth following oxygen loss. This regulation by oxygen affects the variance in gene expression but leaves the mean unchanged. We show that the oxygen-sensitive transcription factor IscR is the key regulator of variability. Oxygen causes IscR to repress expression of a TMAO-responsive signaling system, allowing stochastic effects to have a strong effect on the output of the system and resulting in heterogeneous expression of the TMAO reduction machinery. This work reveals a mechanism through which cells regulate molecular noise to enhance fitness.
journal_name
Celljournal_title
Cellauthors
Carey JN,Mettert EL,Roggiani M,Myers KS,Kiley PJ,Goulian Mdoi
10.1016/j.cell.2018.02.005subject
Has Abstractpub_date
2018-03-22 00:00:00pages
196-207.e14issue
1eissn
0092-8674issn
1097-4172pii
S0092-8674(18)30149-1journal_volume
173pub_type
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