Abstract:
:Three recent papers reveal a fascinating link between pol II termination and ribonucleolytic decay of the nascent transcript by a 5'-3' exonuclease (yeast Rat1 and human Xrn2). The exonuclease travels with pol II and gains access to the nascent RNA after endonucleolytic cleavage at the poly(A) site or at a second cotranscriptional cleavage site (CoTC). It is then thought to track in a 5'-3' direction like a guided torpedo that ultimately helps dissociate the RNA polymerase elongation complex.
journal_name
Celljournal_title
Cellauthors
Luo W,Bentley Ddoi
10.1016/j.cell.2004.11.041subject
Has Abstractpub_date
2004-12-29 00:00:00pages
911-4issue
7eissn
0092-8674issn
1097-4172pii
S0092867404011456journal_volume
119pub_type
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