The Rule of Three for Prizes in Science and the Bold Triptychs of Francis Bacon.

abstract：:Unique loci in the human genome were examined with restriction enzymes in order to detect restriction fragment length polymorphisms (RFLPs). Of 31 arbitrary loci, nine were detectably polymorphic, reflecting ten polymorphic restriction sites. Nine of the ten polymorphic sites were revealed with two restriction enzymes...

journal_title：Cell

authors： Barker D,Schafer M,White R

更新日期：1984-01-01 00:00:00

abstract：:We constructed rabbit beta-globin genes with deletions in the large intron, extending from the midpoint toward the 5' or 3' splice sites. Analysis of transcripts in transformed HeLa cells showed that six 5' proximal intron nucleotides allowed normal splicing. Correct splicing at the 3' splice site required 12 or more ...

journal_title：Cell

authors： Wieringa B,Hofer E,Weissmann C

更新日期：1984-07-01 00:00:00

abstract：:Developing systems exhibit robust and tolerant properties in the form of compensation and competition within cell groups. Fundamentally, these behaviors are governed by mechanisms that elicit proliferation and apoptosis. Recent insights from the Drosophila system implicate new determinants that specify "winners" and "...

journal_title：Cell

authors： Abrams JM

更新日期：2002-08-23 00:00:00

abstract：:The coactivator PGC-1alpha is a key regulator of mitochondrial biogenesis and respiration, mediating expression of several transcription factors required for these programs. Three new studies reveal that PGC-1alpha expression is downregulated in patients with Huntington's disease (HD) and in several animal models of t...

journal_title：Cell

authors： McGill JK,Beal MF

更新日期：2006-11-03 00:00:00

abstract：:We wished to learn whether the genomes of strains of EMB isolated from patients with infectious mononucleosis are consistently distinguishable from those of strains from Burkitt's lymphoma. The genome of a new transforming strains (FF41) of EBV isolated from saliva of a patient with uncomplicated infectious mononucleo...

journal_title：Cell

authors： Fischer DK,Miller G,Gradoville L,Heston L,Westrate MW,Maris W,Wright J,Brandsma J,Summers WC

更新日期：1981-05-01 00:00:00

abstract：:MicroRNAs have been implicated as regulators of embryonic stem (ES) cell self-renewal and pluripotency. In this issue, Xu et al. (2009) demonstrate that miR-145 facilitates ES cell differentiation by repressing the core pluripotency factors OCT4, SOX2, and KLF4, thereby silencing the self-renewal program. ...

journal_title：Cell

authors： Chivukula RR,Mendell JT

更新日期：2009-05-15 00:00:00

abstract：:The HVEM (TNFRSF14) receptor gene is among the most frequently mutated genes in germinal center lymphomas. We report that loss of HVEM leads to cell-autonomous activation of B cell proliferation and drives the development of GC lymphomas in vivo. HVEM-deficient lymphoma B cells also induce a tumor-supportive microenvi...

journal_title：Cell

authors： Boice M,Salloum D,Mourcin F,Sanghvi V,Amin R,Oricchio E,Jiang M,Mottok A,Denis-Lagache N,Ciriello G,Tam W,Teruya-Feldstein J,de Stanchina E,Chan WC,Malek SN,Ennishi D,Brentjens RJ,Gascoyne RD,Cogné M,Tarte K,Wende

更新日期：2016-10-06 00:00:00

abstract：:Netrins are bifunctional: they attract some axons and repel others. Netrin receptors of the Deleted in Colorectal Cancer (DCC) family are implicated in attraction and those of the UNC5 family in repulsion, but genetic evidence also suggests involvement of the DCC protein UNC-40 in some cases of repulsion. To test whet...

journal_title：Cell

authors： Hong K,Hinck L,Nishiyama M,Poo MM,Tessier-Lavigne M,Stein E

更新日期：1999-06-25 00:00:00

abstract：:H2S is an endogenous gasotransmitter that plays an important role in physiological conditions. In this issue, Das et al. provide evidence that SIRT1-dependent angiogenesis is augmented by H2S-findings reinforced by Longchamp et al., who demonstrate that H2S-dependent angiogenesis is triggered by amino acid deprivation...

journal_title：Cell

authors： Arumugam TV,Kennedy BK

更新日期：2018-03-22 00:00:00

abstract：:The rate of in vivo transcription from the E. coli tRNA and rRNA promoters depends on both cellular growth rate and aminoacid availability. To investigate the molecular mechanisms involved we determined the extent of interaction of RNA polymerase with the promoter of the tyrT stable RNA gene. We show that the enzyme c...

journal_title：Cell

authors： Travers AA,Lamond AI,Mace HA,Berman ML

更新日期：1983-11-01 00:00:00

abstract：:We have identified mutations in Drosophila endophilin to study its function in vivo. Endophilin is required presynaptically at the neuromuscular junction, and absence of Endophilin dramatically impairs endocytosis in vivo. Mutant larvae that lack Endophilin fail to take up FM1-43 dye in synaptic boutons, indicating an...

journal_title：Cell

authors： Verstreken P,Kjaerulff O,Lloyd TE,Atkinson R,Zhou Y,Meinertzhagen IA,Bellen HJ

更新日期：2002-04-05 00:00:00

abstract：:Using X-ray crystallography, we have directly observed the path of mRNA in the 70S ribosome in Fourier difference maps at 7 A resolution. About 30 nucleotides of the mRNA are wrapped in a groove that encircles the neck of the 30S subunit. The Shine-Dalgarno helix is bound in a large cleft between the head and the back...

journal_title：Cell

authors： Yusupova GZ,Yusupov MM,Cate JH,Noller HF

更新日期：2001-07-27 00:00:00

abstract：:One of the important events in synapse formation is the accumulation of neurotransmitter receptors beneath the presynaptic nerve terminal. Agrin is a component of the synaptic basal lamina that induces the clustering of acetylcholine receptors when bath-applied to muscle fibers in culture. When a cDNA encoding a putat...

journal_title：Cell

authors： Campanelli JT,Hoch W,Rupp F,Kreiner T,Scheller RH

更新日期：1991-11-29 00:00:00

abstract：:Trigger factor (TF) is a molecular chaperone that binds to bacterial ribosomes where it contacts emerging nascent chains, but TF is also abundant free in the cytosol where its activity is less well characterized. In vitro studies show that TF promotes protein refolding. We find here that ribosome-free TF stably associ...

journal_title：Cell

authors： Martinez-Hackert E,Hendrickson WA

更新日期：2009-09-04 00:00:00

abstract：:To reconstruct modern human evolutionary history and identify loci that have shaped hunter-gatherer adaptation, we sequenced the whole genomes of five individuals in each of three different hunter-gatherer populations at > 60× coverage: Pygmies from Cameroon and Khoesan-speaking Hadza and Sandawe from Tanzania. We ide...

journal_title：Cell

authors： Lachance J,Vernot B,Elbers CC,Ferwerda B,Froment A,Bodo JM,Lema G,Fu W,Nyambo TB,Rebbeck TR,Zhang K,Akey JM,Tishkoff SA

更新日期：2012-08-03 00:00:00

abstract：:Conversion of glial cells into functional neurons represents a potential therapeutic approach for replenishing neuronal loss associated with neurodegenerative diseases and brain injury. Previous attempts in this area using expression of transcription factors were hindered by the low conversion efficiency and failure o...

journal_title：Cell

authors： Zhou H,Su J,Hu X,Zhou C,Li H,Chen Z,Xiao Q,Wang B,Wu W,Sun Y,Zhou Y,Tang C,Liu F,Wang L,Feng C,Liu M,Li S,Zhang Y,Xu H,Yao H,Shi L,Yang H

更新日期：2020-04-30 00:00:00

abstract：:Null mutant mice for retinoic acid receptor gamma 2 (RAR gamma 2) or all RAR gamma isoforms were generated. RAR gamma 2 mutants appeared normal, whereas RAR gamma mutants exhibited growth deficiency, early lethality, and male sterility due to squamous metaplasia of the seminal vesicles and prostate. These defects were...

journal_title：Cell

authors： Lohnes D,Kastner P,Dierich A,Mark M,LeMeur M,Chambon P

更新日期：1993-05-21 00:00:00

abstract：:The Clock mutation lengthens periodicity and reduces amplitude of circadian rhythms in mice. The effects of Clock are cell intrinsic and can be observed at the level of single neurons in the suprachiasmatic nucleus. To address how cells of contrasting genotype functionally interact in vivo to control circadian behavio...

journal_title：Cell

authors： Low-Zeddies SS,Takahashi JS

更新日期：2001-04-06 00:00:00

abstract：:We have previously cloned lethal(2)giant larvae, a tumor-suppressor gene of Drosophila that normally controls cell proliferation and/or differentiation in the optic centers of the brain and the imaginal discs. Here we describe the structure of the l(2)gl genes as determined by sequencing genomic and cDNA clones. The s...

journal_title：Cell

authors： Jacob L,Opper M,Metzroth B,Phannavong B,Mechler BM

更新日期：1987-07-17 00:00:00

abstract：:Despite an ever-expanding database of sequenced mammalian genomes to be mined for clues, the emergence of the unique human brain remains an evolutionary enigma. In their new study, trawl the human genome and those of other mammals in search of short conserved DNA elements that show extremely rapid evolution only in hu...

journal_title：Cell

authors： Amadio JP,Walsh CA

更新日期：2006-09-22 00:00:00

abstract：:To understand the role of FoxO family members in hematopoiesis, we conditionally deleted FoxO1, FoxO3, and FoxO4 in the adult hematopoietic system. FoxO-deficient mice exhibited myeloid lineage expansion, lymphoid developmental abnormalities, and a marked decrease of the lineage-negative Sca-1+, c-Kit+ (LSK) compartme...

journal_title：Cell

authors： Tothova Z,Kollipara R,Huntly BJ,Lee BH,Castrillon DH,Cullen DE,McDowell EP,Lazo-Kallanian S,Williams IR,Sears C,Armstrong SA,Passegué E,DePinho RA,Gilliland DG

更新日期：2007-01-26 00:00:00

abstract：:The 2013-2015 West African epidemic of Ebola virus disease (EVD) reminds us of how little is known about biosafety level 4 viruses. Like Ebola virus, Lassa virus (LASV) can cause hemorrhagic fever with high case fatality rates. We generated a genomic catalog of almost 200 LASV sequences from clinical and rodent reserv...

journal_title：Cell

authors： Andersen KG,Shapiro BJ,Matranga CB,Sealfon R,Lin AE,Moses LM,Folarin OA,Goba A,Odia I,Ehiane PE,Momoh M,England EM,Winnicki S,Branco LM,Gire SK,Phelan E,Tariyal R,Tewhey R,Omoniwa O,Fullah M,Fonnie R,Fonnie M,

更新日期：2015-08-13 00:00:00

abstract：:Recombinant DNAs containing the E. coli plasmid pSC101 and mouse cell (La9) mitochondrial DNA (mtDNA) were formed in vitro via ligation of DNA fragments from limit EcoRI endonuclease digests and were used to transform E. coli K12. Four structurally different recombinant plasmid DNAs from transformed clones were charac...

journal_title：Cell

authors： Brown WM,Watson RM,Vinograd J,Tait KM,Boyer HW,Goodman HM

更新日期：1976-04-01 00:00:00

abstract：:In eukaryotic cells, organelles and the cytoskeleton undergo highly dynamic yet organized interactions capable of orchestrating complex cellular functions. Visualizing these interactions requires noninvasive, long-duration imaging of the intracellular environment at high spatiotemporal resolution and low background. T...

journal_title：Cell

authors： Guo Y,Li D,Zhang S,Yang Y,Liu JJ,Wang X,Liu C,Milkie DE,Moore RP,Tulu US,Kiehart DP,Hu J,Lippincott-Schwartz J,Betzig E,Li D

更新日期：2018-11-15 00:00:00

abstract：:The transmembrane ligand ephrinB2 and its cognate Eph receptor tyrosine kinases are important regulators of vascular morphogenesis. EphrinB2 may have an active signaling role, resulting in bi-directional signal transduction downstream of both ephrinB2 and Eph receptors. To separate the ligand and receptor-like functio...

journal_title：Cell

authors： Adams RH,Diella F,Hennig S,Helmbacher F,Deutsch U,Klein R

更新日期：2001-01-12 00:00:00

abstract：:The genetic dependencies of human cancers widely vary. Here, we catalog this heterogeneity and use it to identify functional gene interactions and genotype-dependent liabilities in cancer. By using genome-wide CRISPR-based screens, we generate a gene essentiality dataset across 14 human acute myeloid leukemia (AML) ce...

journal_title：Cell

authors： Wang T,Yu H,Hughes NW,Liu B,Kendirli A,Klein K,Chen WW,Lander ES,Sabatini DM

更新日期：2017-02-23 00:00:00

abstract：:Genetic analyses in Drosophila have demonstrated that the multipass membrane protein Smoothened (Smo) is essential for all Hedgehog signaling. We show that Smo acts epistatic to Ptc1 to mediate Shh and Ihh signaling in the early mouse embryo. Smo and Shh/Ihh compound mutants have identical phenotypes: embryos fail to ...

journal_title：Cell

authors： Zhang XM,Ramalho-Santos M,McMahon AP

更新日期：2001-06-15 00:00:00

abstract：:In the nucleus of eukaryotic cells, RNA decay in the 3'-5' direction is carried out by a complex of exonucleases called the exosome. Surprisingly, the purified exosome shows only weak activity in vitro. Two papers in this issue of Cell, by LaCava et al. (2005) and Wyers et al. (2005), and a third report by Vanacova et...

journal_title：Cell

authors： Jensen TH,Moore C

更新日期：2005-06-03 00:00:00

abstract：:Type III secretion systems mediate export of virulence proteins and flagellar assembly subunits in Gram-negative bacteria. Chaperones specific to each class of secreted protein are believed to prevent degradation of the secreted substrates. We show that an additional role of chaperones may be to regulate translation o...

journal_title：Cell

authors： Karlinsey JE,Lonner J,Brown KL,Hughes KT

更新日期：2000-08-18 00:00:00

abstract：:Zika virus (ZIKV) is associated with severe neuropathology in neonates as well as Guillain-Barré syndrome and other neurologic disorders in adults. Prolonged viral shedding has been reported in semen, suggesting the presence of anatomic viral reservoirs. Here we show that ZIKV can persist in cerebrospinal fluid (CSF) ...

journal_title：Cell

authors： Aid M,Abbink P,Larocca RA,Boyd M,Nityanandam R,Nanayakkara O,Martinot AJ,Moseley ET,Blass E,Borducchi EN,Chandrashekar A,Brinkman AL,Molloy K,Jetton D,Tartaglia LJ,Liu J,Best K,Perelson AS,De La Barrera RA,Lewis MG

更新日期：2017-05-04 00:00:00