Abstract:
:The coactivator PGC-1alpha is a key regulator of mitochondrial biogenesis and respiration, mediating expression of several transcription factors required for these programs. Three new studies reveal that PGC-1alpha expression is downregulated in patients with Huntington's disease (HD) and in several animal models of this neurodegenerative disorder, implicating PGC-1alpha in HD pathogenesis and providing a connection between impaired energy metabolism and neurodegeneration.
journal_name
Celljournal_title
Cellauthors
McGill JK,Beal MFdoi
10.1016/j.cell.2006.10.023subject
Has Abstractpub_date
2006-11-03 00:00:00pages
465-8issue
3eissn
0092-8674issn
1097-4172pii
S0092-8674(06)01353-5journal_volume
127pub_type
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