Abstract:
:In thymic epithelial cells, the protein Aire (autoimmune regulator) induces the ectopic expression of hundreds of peripheral tissue antigens, thus enlarging the repertoire of antigens available for the induction of central T cell tolerance. By analyzing Aire's interacting partners, Abramson et al. (2010) shed new light on this unorthodox form of gene expression.
journal_name
Celljournal_title
Cellauthors
Kyewski B,Peterson Pdoi
10.1016/j.cell.2009.12.036subject
Has Abstractpub_date
2010-01-08 00:00:00pages
24-6issue
1eissn
0092-8674issn
1097-4172pii
S0092-8674(09)01622-5journal_volume
140pub_type
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