Translational recoding induced by G-rich mRNA sequences that form unusual structures.

abstract：:To assess telomerase as a cancer therapeutic target and determine adaptive mechanisms to telomerase inhibition, we modeled telomerase reactivation and subsequent extinction in T cell lymphomas arising in Atm(-/-) mice engineered with an inducible telomerase reverse transcriptase allele. Telomerase reactivation in the ...

journal_title：Cell

authors： Hu J,Hwang SS,Liesa M,Gan B,Sahin E,Jaskelioff M,Ding Z,Ying H,Boutin AT,Zhang H,Johnson S,Ivanova E,Kost-Alimova M,Protopopov A,Wang YA,Shirihai OS,Chin L,DePinho RA

更新日期：2012-02-17 00:00:00

abstract：:Five years into the human postgenomic era, we are gaining considerable knowledge about host-pathogen interactions through host genomes. This "infectogenomics" approach should yield further insights into both diagnostic and therapeutic advances, as well as normal cellular function. ...

journal_title：Cell

authors： Kellam P,Weiss RA

更新日期：2006-02-24 00:00:00

abstract：:Posttranslational modifications of histones have been strongly correlated with transcriptional regulation. In this issue of Cell, comprehensively examined the nature of arginine methyltransferases and histone modifications in p53-mediated transcription. ...

journal_title：Cell

authors： Fingerman IM,Briggs SD

更新日期：2004-06-11 00:00:00

abstract：:The transcription factor NRF2 is a master regulator of the cellular antioxidant response, and it is often genetically activated in non-small-cell lung cancers (NSCLCs) by, for instance, mutations in the negative regulator KEAP1. While direct pharmacological inhibition of NRF2 has proven challenging, its aberrant activ...

journal_title：Cell

authors： Bar-Peled L,Kemper EK,Suciu RM,Vinogradova EV,Backus KM,Horning BD,Paul TA,Ichu TA,Svensson RU,Olucha J,Chang MW,Kok BP,Zhu Z,Ihle NT,Dix MM,Jiang P,Hayward MM,Saez E,Shaw RJ,Cravatt BF

更新日期：2017-10-19 00:00:00

abstract：:Fertilized clam embryos synthesize several new cell-cycle-related proteins. The cloned cDNA and derived amino acid sequences of one of these, cyclin A, are presented here. Immunoblots with an anti-cyclin A antibody reveal that cyclin A is undetectable in oocytes, appears within 15 min of fertilization, and is destroye...

journal_title：Cell

authors： Swenson KI,Farrell KM,Ruderman JV

更新日期：1986-12-26 00:00:00

abstract：:Hereditary xerocytosis is thought to be a rare genetic condition characterized by red blood cell (RBC) dehydration with mild hemolysis. RBC dehydration is linked to reduced Plasmodium infection in vitro; however, the role of RBC dehydration in protection against malaria in vivo is unknown. Most cases of hereditary xer...

journal_title：Cell

authors： Ma S,Cahalan S,LaMonte G,Grubaugh ND,Zeng W,Murthy SE,Paytas E,Gamini R,Lukacs V,Whitwam T,Loud M,Lohia R,Berry L,Khan SM,Janse CJ,Bandell M,Schmedt C,Wengelnik K,Su AI,Honore E,Winzeler EA,Andersen KG,Patapou

更新日期：2018-04-05 00:00:00

abstract：:Newly synthesized transcripts are usually spliced during transcription or immediately thereafter. So pre-mRNA splicing has been presumed to occur exclusively in the cell nucleus. In this issue of Cell, Denis et al. (2005) now report the presence of functional spliceosomes and signal-dependent pre-mRNA splicing in the ...

journal_title：Cell

authors： Meshorer E,Misteli T

更新日期：2005-08-12 00:00:00

abstract：:The mitotic checkpoint ensures proper chromosome segregation by delaying anaphase until chromosomes are aligned on the spindle. Following prolonged spindle damage, however, cells eventually exit mitosis and undergo apoptosis. We show here that a murine homolog of the yeast mitotic checkpoint gene BUB1 localizes to the...

journal_title：Cell

authors： Taylor SS,McKeon F

更新日期：1997-05-30 00:00:00

abstract：:The redox-regulated chaperone Hsp33 protects organisms against oxidative stress that leads to protein unfolding. Activation of Hsp33 is triggered by the oxidative unfolding of its own redox-sensor domain, making Hsp33 a member of a recently discovered class of chaperones that require partial unfolding for full chapero...

journal_title：Cell

authors： Reichmann D,Xu Y,Cremers CM,Ilbert M,Mittelman R,Fitzgerald MC,Jakob U

更新日期：2012-03-02 00:00:00

abstract：:The 5' terminal structure of the mRNA synthesized in vitro by the virion-associated RNA polymerase of vesicular stomatitis virus in the presence of S-adenosyl-L-methione consists of 7-methyl guanosine linked to 2'-O-methyl adenosine through a 5'-5' pyrophosphate bond as m7G(5')ppp(5')A-m-p ... The alpha and beta phosp...

journal_title：Cell

authors： Abraham G,Rhodes DP,Banerjee AK

更新日期：1975-05-01 00:00:00

abstract：:Kit/SCF signaling and Mitf-dependent transcription are both essential for melanocyte development and pigmentation. To identify Mitf-dependent Kit transcriptional targets in primary melanocytes, microarray studies were undertaken. Among identified targets was BCL2, whose germline deletion produces melanocyte loss and w...

journal_title：Cell

authors： McGill GG,Horstmann M,Widlund HR,Du J,Motyckova G,Nishimura EK,Lin YL,Ramaswamy S,Avery W,Ding HF,Jordan SA,Jackson IJ,Korsmeyer SJ,Golub TR,Fisher DE

更新日期：2002-06-14 00:00:00

abstract：:Bacteria can respond to adverse environmental conditions by drastically reducing or even ceasing metabolic activity. They must then determine that conditions have improved before exiting dormancy, and one indication of such a change is the growth of other bacteria in the local environment. Growing bacteria release mur...

journal_title：Cell

authors： Shah IM,Laaberki MH,Popham DL,Dworkin J

更新日期：2008-10-31 00:00:00

abstract：:FtsK acts at the bacterial division septum to couple chromosome segregation with cell division. We demonstrate that a truncated FtsK derivative, FtsK(50C), uses ATP hydrolysis to translocate along duplex DNA as a multimer in vitro, consistent with FtsK having an in vivo role in pumping DNA through the closing division...

journal_title：Cell

authors： Aussel L,Barre FX,Aroyo M,Stasiak A,Stasiak AZ,Sherratt D

更新日期：2002-01-25 00:00:00

abstract：:Embryonal carcinoma cells derived from murine teratocarcinomas are able to differentiate into the same variety of tissue types as early embryonic cells. Because embryonal carcinoma cells resemble those of the embryo at a stage before X chromosome inactivation has occurred in females embryonal carcinoma cells containin...

journal_title：Cell

authors： McBurney MW,Adamson ED

更新日期：1976-09-01 00:00:00

abstract：:The c-Abl tyrosine kinase is inhibited by mechanisms that are poorly understood. Disruption of these mechanisms in the Bcr-Abl oncoprotein leads to several forms of human leukemia. We found that like Src kinases, c-Abl 1b is activated by phosphotyrosine ligands. Ligand-activated c-Abl is particularly sensitive to the ...

journal_title：Cell

authors： Hantschel O,Nagar B,Guettler S,Kretzschmar J,Dorey K,Kuriyan J,Superti-Furga G

更新日期：2003-03-21 00:00:00

abstract：:Temperature compensation of circadian clocks is an unsolved problem with relevance to the general phenomenon of biological compensation. We identify casein kinase 2 (CK2) as a key regulator of temperature compensation of the Neurospora clock by determining that two long-standing clock mutants, chrono and period-3, dis...

journal_title：Cell

authors： Mehra A,Shi M,Baker CL,Colot HV,Loros JJ,Dunlap JC

更新日期：2009-05-15 00:00:00

abstract：:Mutations at the X-linked disconnected locus of D. melanogaster lead to the failure of adult photoreceptor axons to innervate their target cells in the developing optic lobes of the third instar larva, resulting in flies that have rudimentary optic ganglia. The cascade of epigenetic events leading to the adult disconn...

journal_title：Cell

authors： Steller H,Fischbach KF,Rubin GM

更新日期：1987-09-25 00:00:00

abstract：:Monkey cells synthesizing SV40 large T antigen were lysed and the extracts immunoprecipitated with either monoclonal anti-T antibody or monoclonal antibody to p110-114, the product of the retinoblastoma susceptibility gene (Rb). T and p110-114 coprecipitated in each case, implying that the proteins are complexed with ...

journal_title：Cell

authors： DeCaprio JA,Ludlow JW,Figge J,Shew JY,Huang CM,Lee WH,Marsilio E,Paucha E,Livingston DM

更新日期：1988-07-15 00:00:00

abstract：:Stable myoblast cell lines were isolated after a brief exposure of mouse fibroblasts (10T1/2 cells) to 5-azacytidine. We show that transfection of 10T1/2 cells with DNA from these azacytidine-induced myoblasts (or from mouse C2C12 myoblasts) results in myogenic conversion of approximately 1 in 15,000 transfected colon...

journal_title：Cell

authors： Lassar AB,Paterson BM,Weintraub H

更新日期：1986-12-05 00:00:00

abstract：:The elucidation of the genetic code remains among the most influential discoveries in biology. While innumerable studies have validated the general universality of the code and its value in predicting and analyzing protein coding sequences, established and emerging work has also suggested that full genome decryption m...

journal_title：Cell

authors： Brar GA

更新日期：2016-12-15 00:00:00

abstract：:Clarification of the information processing system in bacterial sensing has been obtained by studying mutants that lack the capacity to modify receptors covalently. The remaining part of the system is able to receive signals from the receptor, to respond with partial adaptation, and to exhibit a chemotactic response. ...

journal_title：Cell

authors： Stock J,Kersulis G,Koshland DE Jr

更新日期：1985-09-01 00:00:00

abstract：:The single, chloroplast encoded gene for the large subunit of ribulose-1,5-bisphosphate carboxylase/oxygenase (rbcL) from Euglena gracilis is found to contain nine intervening sequences. The intervening sequences were identified by heteroduplex analysis between Euglena rbcL and the non-intron-containing rbcL from Spin...

journal_title：Cell

authors： Koller B,Gingrich JC,Stiegler GL,Farley MA,Delius H,Hallick RB

更新日期：1984-02-01 00:00:00

abstract：:Long pyrimidine tracts, purified from Drosophila melanogaster DNA after treatment with formic acid-diphenylamine, were used as template for E. coli RNA polymerase to produce a polynucleotide containing only purines. This polypurine RNA hybridized specifically to D. melanogaster DNA with high efficiency at low Cot valu...

journal_title：Cell

authors： Sederoff R,Lowenstein L

更新日期：1975-06-01 00:00:00

abstract：:Intestinal peristalsis is a dynamic physiologic process influenced by dietary and microbial changes. It is tightly regulated by complex cellular interactions; however, our understanding of these controls is incomplete. A distinct population of macrophages is distributed in the intestinal muscularis externa. We demonst...

journal_title：Cell

authors： Muller PA,Koscsó B,Rajani GM,Stevanovic K,Berres ML,Hashimoto D,Mortha A,Leboeuf M,Li XM,Mucida D,Stanley ER,Dahan S,Margolis KG,Gershon MD,Merad M,Bogunovic M

更新日期：2014-07-17 00:00:00

abstract：:Using insertional mutagenesis, we have isolated a "stalky" mutant in which cells destined to become spores end up as stalk cells. Similar mutants were previously observed after chemical mutagenesis, but the affected gene could not be isolated. Our mutant, like the previous ones, is in stkA. Its defect is cell-autonomo...

journal_title：Cell

authors： Chang WT,Newell PC,Gross JD

更新日期：1996-11-01 00:00:00

abstract：:We have generated mice carrying a germline mutation in the tyrosine kinase catalytic domain of the trkB gene. This mutation eliminates expression of gp145trkB, a protein-tyrosine kinase that serves as the signaling receptor for two members of the nerve growth factor family of neurotrophins, brain-derived neurotrophic ...

journal_title：Cell

authors： Klein R,Smeyne RJ,Wurst W,Long LK,Auerbach BA,Joyner AL,Barbacid M

更新日期：1993-10-08 00:00:00

abstract：:Stem cells are highly resistant to viral infection compared to their differentiated progeny; however, the mechanism is mysterious. Here, we analyzed gene expression in mammalian stem cells and cells at various stages of differentiation. We find that, conserved across species, stem cells express a subset of genes previ...

journal_title：Cell

authors： Wu X,Dao Thi VL,Huang Y,Billerbeck E,Saha D,Hoffmann HH,Wang Y,Silva LAV,Sarbanes S,Sun T,Andrus L,Yu Y,Quirk C,Li M,MacDonald MR,Schneider WM,An X,Rosenberg BR,Rice CM

更新日期：2018-01-25 00:00:00

abstract：:Cytotoxic brain edema triggered by neuronal swelling is the chief cause of mortality following brain trauma and cerebral infarct. Using fluorescence lifetime imaging to analyze contributions of intracellular ionic changes in brain slices, we find that intense Na(+) entry triggers a secondary increase in intracellular ...

journal_title：Cell

authors： Rungta RL,Choi HB,Tyson JR,Malik A,Dissing-Olesen L,Lin PJC,Cain SM,Cullis PR,Snutch TP,MacVicar BA

更新日期：2015-04-23 00:00:00

abstract：:Isolation of genes encoding the receptors for steroids, retinoids, vitamin D, and thyroid hormone and their structural and functional analysis revealed an evolutionarily conserved template for nuclear hormone receptors. This discovery sparked identification of numerous genes encoding related proteins, termed orphan re...

journal_title：Cell

authors： Evans RM,Mangelsdorf DJ

更新日期：2014-03-27 00:00:00

abstract：:The organization of neuronal systems is often dependent on activity and competition between cells. In olfaction, the X-linked OCNC1 channel subunit is subject to random inactivation and is essential for odorant-evoked activity. Reporter-tagged OCNC1 mutant mice permit the visualization of OCNC1-deficient olfactory neu...

journal_title：Cell

authors： Zhao H,Reed RR

更新日期：2001-03-09 00:00:00