Infectogenomics: insights from the host genome into infectious diseases.

abstract：:DNA repair was measured in the dihydrofolate reductase gene in Chinese hamster ovary cells, amplified for the gene, by quantitating pyrimidine dimers with a specific UV-endonuclease. More than two thirds of the dimers had been removed from a 14.1 kb restriction fragment of the gene by 26 hr after irradiation (20 J/m2)...

journal_title：Cell

authors： Bohr VA,Smith CA,Okumoto DS,Hanawalt PC

更新日期：1985-02-01 00:00:00

abstract：:The intestinal epithelium is a highly structured tissue composed of repeating crypt-villus units. Enterocytes perform the diverse tasks of absorbing a wide range of nutrients while protecting the body from the harsh bacterium-rich environment. It is unknown whether these tasks are spatially zonated along the villus ax...

journal_title：Cell

authors： Moor AE,Harnik Y,Ben-Moshe S,Massasa EE,Rozenberg M,Eilam R,Bahar Halpern K,Itzkovitz S

更新日期：2018-11-01 00:00:00

abstract：:The chief mechanism used by bacteria for sensing their environment is based on two conserved proteins: a sensor histidine kinase (HK) and an effector response regulator (RR). The signal transduction process involves highly conserved domains of both proteins that mediate autokinase, phosphotransfer, and phosphatase act...

journal_title：Cell

authors： Casino P,Rubio V,Marina A

更新日期：2009-10-16 00:00:00

abstract：:Nuclear exclusion of the forkhead transcription factor FOXO3a by protein kinase Akt contributes to cell survival. We investigated the pathological relationship between phosphoylated-Akt (Akt-p) and FOXO3a in primary tumors. Surprisingly, FOXO3a was found to be excluded from the nuclei of some tumors lacking Akt-p, sug...

journal_title：Cell

authors： Hu MC,Lee DF,Xia W,Golfman LS,Ou-Yang F,Yang JY,Zou Y,Bao S,Hanada N,Saso H,Kobayashi R,Hung MC

更新日期：2004-04-16 00:00:00

abstract：:Three membrane microdomains can be identified on docked vacuoles: "outside" membrane, not in contact with other vacuoles, "boundary" membrane that contacts adjacent vacuoles, and "vertices," where boundary and outside membrane meet. In living cells and in vitro, vacuole fusion occurs at vertices rather than from a cen...

journal_title：Cell

authors： Wang L,Seeley ES,Wickner W,Merz AJ

更新日期：2002-02-08 00:00:00

abstract：:Cell lines from rhabdomyosarcomas, which are tumors of muscle origin, have been used as models of CD4-independent HIV infection. These cell lines can be induced to differentiate in vitro. We report here that the vpr gene of HIV1 is sufficient for the differentiation of the human rhabdomyosarcoma cell line TE671. Diffe...

journal_title：Cell

authors： Levy DN,Fernandes LS,Williams WV,Weiner DB

更新日期：1993-02-26 00:00:00

abstract：:MicroRNAs have been implicated as regulators of embryonic stem (ES) cell self-renewal and pluripotency. In this issue, Xu et al. (2009) demonstrate that miR-145 facilitates ES cell differentiation by repressing the core pluripotency factors OCT4, SOX2, and KLF4, thereby silencing the self-renewal program. ...

journal_title：Cell

authors： Chivukula RR,Mendell JT

更新日期：2009-05-15 00:00:00

abstract：:The cocrystal structure of human poly(A)-binding protein (PABP) has been determined at 2.6 A resolution. PABP recognizes the 3' mRNA poly(A) tail and plays critical roles in eukaryotic translation initiation and mRNA stabilization/degradation. The minimal PABP used in this study consists of the N-terminal two RRM-type...

journal_title：Cell

authors： Deo RC,Bonanno JB,Sonenberg N,Burley SK

更新日期：1999-09-17 00:00:00

abstract：:In order to identify nucleotide sequences required for efficient and accurate polyadenylation of mRNA precursors, we have constructed a series of mutations in the X. laevis beta 1-globin gene and analyzed transcripts produced upon microinjection into Xenopus oocytes. Small deletion and linker replacement mutations, wh...

journal_title：Cell

authors： Mason PJ,Elkington JA,Lloyd MM,Jones MB,Williams JG

更新日期：1986-07-18 00:00:00

abstract：:Using a defined RNA polymerase II (pol II) transcription system, we have investigated the roles of basal factors at discrete stages during the transcription cycle (e.g., initiation, promoter clearance, and transcript elongation). Abortive initiation assays revealed that TATA-binding protein, transcription factors TFII...

journal_title：Cell

authors： Goodrich JA,Tjian R

更新日期：1994-04-08 00:00:00

abstract：:Nucleosome assembly following DNA replication and gene transcription is important to maintain genome stability and epigenetic information. Newly synthesized histones H3-H4 first bind histone chaperone Asf1 and are then transferred to other chaperones for nucleosome assembly. However, it is unknown how H3-H4 is transfe...

journal_title：Cell

authors： Han J,Zhang H,Zhang H,Wang Z,Zhou H,Zhang Z

更新日期：2013-11-07 00:00:00

abstract：:Metabolic coordination between neurons and astrocytes is critical for the health of the brain. However, neuron-astrocyte coupling of lipid metabolism, particularly in response to neural activity, remains largely uncharacterized. Here, we demonstrate that toxic fatty acids (FAs) produced in hyperactive neurons are tran...

journal_title：Cell

authors： Ioannou MS,Jackson J,Sheu SH,Chang CL,Weigel AV,Liu H,Pasolli HA,Xu CS,Pang S,Matthies D,Hess HF,Lippincott-Schwartz J,Liu Z

更新日期：2019-05-30 00:00:00

abstract：:Tumor suppressors block the development of cancer and are often lost during tumor development. Papa et al. show that partial loss of normal PTEN tumor suppressor function can be compounded by additional disruption caused by the expression of inactive mutant PTEN protein. This has significant implications for patients ...

journal_title：Cell

authors： Leslie NR,den Hertog J

更新日期：2014-04-24 00:00:00

abstract：:Periodic transcription of yeast histone genes has been demonstrated by DNA excess filter hybridization of in vivo pulse-labeled RNA isolated from synchronous cell cultures. Using strains carrying cell division cycle (cdc) mutations, we show that both activation and termination of transcription are determined by tempor...

journal_title：Cell

authors： Hereford L,Bromley S,Osley MA

更新日期：1982-08-01 00:00:00

abstract：:247 independent events involving insertion of the TN3 transposable element into a 4 kb constructed plasmid (pTU4) of partially known DNA sequence were studied by restriction endonuclease mapping, and 65 of these insertion sites were examined further by DNA sequence analysis. Our results show that the previously propos...

journal_title：Cell

authors： Tu CP,Cohen SN

更新日期：1980-01-01 00:00:00

abstract：:We wished to learn whether the genomes of strains of EMB isolated from patients with infectious mononucleosis are consistently distinguishable from those of strains from Burkitt's lymphoma. The genome of a new transforming strains (FF41) of EBV isolated from saliva of a patient with uncomplicated infectious mononucleo...

journal_title：Cell

authors： Fischer DK,Miller G,Gradoville L,Heston L,Westrate MW,Maris W,Wright J,Brandsma J,Summers WC

更新日期：1981-05-01 00:00:00

abstract：:It has been long appreciated that, during meiosis, DNA replication is coordinated with the subsequent formation of the double-strand breaks (DSBs) that initiate recombination, but a mechanistic understanding of this process was elusive. We now show that, in yeast, the replisome-associated components Tof1 and Csm3 phys...

journal_title：Cell

authors： Murakami H,Keeney S

更新日期：2014-08-14 00:00:00

abstract：:To elucidate the evolutionary origin of nervous system centralization, we investigated the molecular architecture of the trunk nervous system in the annelid Platynereis dumerilii. Annelids belong to Bilateria, an evolutionary lineage of bilateral animals that also includes vertebrates and insects. Comparing nervous sy...

journal_title：Cell

authors： Denes AS,Jékely G,Steinmetz PR,Raible F,Snyman H,Prud'homme B,Ferrier DE,Balavoine G,Arendt D

更新日期：2007-04-20 00:00:00

abstract：:Mutations in the single-minded (sim) gene of Drosophila result in the loss of the precursor cells giving rise to the midline cells of the embryonic central nervous system. We have examined the structure of the sim product by sequencing a sim cDNA clone, and have also determined the subcellular localization of the prot...

journal_title：Cell

authors： Crews ST,Thomas JB,Goodman CS

更新日期：1988-01-15 00:00:00

abstract：:Living organisms sense their physical environment through cellular mechanotransduction, which converts mechanical forces into electrical and biochemical signals. In turn, signal transduction serves a wide variety of functions, from basic cellular processes as diverse as proliferation, differentiation, migration, and a...

journal_title：Cell

authors： Delmas P,Coste B

更新日期：2013-10-10 00:00:00

abstract：:A major problem in treatment of cancers arising in steroid-sensitive cells is their inevitable progression to a steroid-insensitive state; current therapies are based on the assumption that hormone insensitivity is associated with loss of receptor. We demonstrate for the first time that breast tumor cells can progress...

journal_title：Cell

authors： Darbre PD,King RJ

更新日期：1987-11-20 00:00:00

abstract：:Transfer RNAs (tRNAs) are primarily viewed as static contributors to gene expression. By developing a high-throughput tRNA profiling method, we find that specific tRNAs are upregulated in human breast cancer cells as they gain metastatic activity. Through loss-of-function, gain-of-function, and clinical-association st...

journal_title：Cell

authors： Goodarzi H,Nguyen HCB,Zhang S,Dill BD,Molina H,Tavazoie SF

更新日期：2016-06-02 00:00:00

abstract：:ATRX is an X-linked gene of the SWI/SNF family, mutations in which cause syndromal mental retardation and downregulation of α-globin expression. Here we show that ATRX binds to tandem repeat (TR) sequences in both telomeres and euchromatin. Genes associated with these TRs can be dysregulated when ATRX is mutated, and ...

journal_title：Cell

authors： Law MJ,Lower KM,Voon HP,Hughes JR,Garrick D,Viprakasit V,Mitson M,De Gobbi M,Marra M,Morris A,Abbott A,Wilder SP,Taylor S,Santos GM,Cross J,Ayyub H,Jones S,Ragoussis J,Rhodes D,Dunham I,Higgs DR,Gibbons RJ

更新日期：2010-10-29 00:00:00

abstract：:The fluid-mosaic model posits a liquid-like plasma membrane, which can flow in response to tension gradients. It is widely assumed that membrane flow transmits local changes in membrane tension across the cell in milliseconds, mediating long-range signaling. Here, we show that propagation of membrane tension occurs qu...

journal_title：Cell

authors： Shi Z,Graber ZT,Baumgart T,Stone HA,Cohen AE

更新日期：2018-12-13 00:00:00

abstract：:The haywire gene of Drosophila encodes a protein with 66% identity to the product of the human ERCC3 gene, associated with xeroderma pigmentosum B (XP-B) and Cockayne's syndrome (CS). XP is a human autosomal recessive disease characterized by extreme sensitivity to ultraviolet irradiation and marked susceptibility to ...

journal_title：Cell

authors： Mounkes LC,Jones RS,Liang BC,Gelbart W,Fuller MT

更新日期：1992-12-11 00:00:00

abstract：:Bacteria and archaea have evolved sophisticated adaptive immune systems that reply on CRISPR loci and a diverse cassette of Cas genes that are classified into three main types and at least eleven subtypes. All CRISPR-Cas immune systems operate through three main stages: acquisition, biogenesis, and interference. This ...

journal_title：Cell

authors： Carter J,Wiedenheft B

更新日期：2015-09-24 00:00:00

abstract：:Two papers published in 1984 by the Varshavsky laboratory revealed that the ubiquitin/proteasome pathway is the principal system for degradation of short-lived proteins in mammalian cells, setting the stage for future demonstrations of this pathway's many regulatory roles. This perspective discusses the impact of thos...

journal_title：Cell

authors： Pickart CM

更新日期：2004-01-23 00:00:00

abstract：:Rat liver interphase chromosomes have telomeres 20-100 kb in length. Micrococcal nuclease digestion of nuclei cleaves telomeres with a uniform 157 bp periodicity, producing soluble particles that sediment in sucrose gradients exactly like oligonucleosomes. The monomeric telomere particles comigrate with nucleosome cor...

journal_title：Cell

authors： Makarov VL,Lejnine S,Bedoyan J,Langmore JP

更新日期：1993-05-21 00:00:00

abstract：:The switch from short-term to long-term facilitation of the synapses between sensory and motor neurons mediating gill and tail withdrawal reflexes in Aplysia requires CREB-mediated transcription and new protein synthesis. We isolated several downstream genes, one of which encodes a neuron-specific ubiquitin C-terminal...

journal_title：Cell

authors： Hegde AN,Inokuchi K,Pei W,Casadio A,Ghirardi M,Chain DG,Martin KC,Kandel ER,Schwartz JH

更新日期：1997-04-04 00:00:00

abstract：:In induced erythroleukemia cells, transcription of the beta-globin gene terminates in a region 600-1500 nucleotides downstream of the poly(A) site. To determine whether this region of the mouse DNA functions to terminate transcription when moved to another genomic site, portions of the putative termination region have...

journal_title：Cell

authors： Falck-Pedersen E,Logan J,Shenk T,Darnell JE Jr

更新日期：1985-04-01 00:00:00