Abstract：
:Rat liver interphase chromosomes have telomeres 20-100 kb in length. Micrococcal nuclease digestion of nuclei cleaves telomeres with a uniform 157 bp periodicity, producing soluble particles that sediment in sucrose gradients exactly like oligonucleosomes. The monomeric telomere particles comigrate with nucleosome core particles on nucleoprotein and DNA gels but do not bind H1. DNAase I cleaves telomere nucleoprotein into a series of bands spaced by about 10.4 bp and with the same intensity distribution as bands from bulk nucleosomes. Removal of H1 from chromatin alters the sedimentation properties of telomeres in parallel with bulk chromatin. Thus, telomeres of mammals are constructed of closely spaced nucleosomes, in contrast with the telomeres of lower eukaryotes, which show no evidence of nucleosomal structure.
journal_name
Celljournal_title
Cellauthors
Makarov VL,Lejnine S,Bedoyan J,Langmore JPdoi
10.1016/0092-8674(93)90256-psubject
Has Abstractpub_date
1993-05-21 00:00:00pages
775-87issue
4eissn
0092-8674issn
1097-4172pii
0092-8674(93)90256-Pjournal_volume
73pub_type
杂志文章相关文献
CELL文献大全abstract：:Spinal muscular atrophy (SMA) is an often fatal neuromuscular disease that has been directly linked to the protein product of the Survival of Motor Neurons (SMN) gene. The SMN protein is tightly associated with a novel protein, SIP1, and together they form a complex with several spliceosomal snRNP proteins. Here we sh...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)80368-2
更新日期：1997-09-19 00:00:00
abstract：:Xenopus laevis oocytes respond to high temperature (greater than 31 degrees C) by the synthesis of one major (70 kilodalton) protein and by a gradual reduction in the rate of normal protein synthesis. In contrast with most other cells, the heat-shock response of Xenopus oocytes is controlled exclusively at the transla...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(82)90443-3
更新日期：1982-07-01 00:00:00
abstract：:The phosphoinositide 3-kinase related kinases (PIKKs) mediate responses to diverse stresses, including DNA double-strand breaks (DSBs), abnormal replication fork progression, the recognition of premature termination codons in mRNAs, and inadequate nutrient availability. Rigorous control of these kinases limits cellula...
journal_title：Cell
pub_type： 杂志文章,评审
doi：10.1016/j.cell.2004.06.023
更新日期：2004-07-09 00:00:00
abstract：:The 90S pre-ribosome is an early biogenesis intermediate formed during co-transcriptional ribosome formation, composed of ∼70 assembly factors and several small nucleolar RNAs (snoRNAs) that associate with nascent pre-rRNA. We report the cryo-EM structure of the Chaetomium thermophilum 90S pre-ribosome, revealing how ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2016.06.014
更新日期：2016-07-14 00:00:00
abstract：:Much of the Y chromosome consists of large palindromic arrays harboring genes that are critical for spermatogenesis. In this issue, Lange et al. (2009) show that although gene conversion within these arrays maintains their integrity, it also permits rare unequal sister chromatid-exchange events within palindromes that...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2009.08.022
更新日期：2009-09-04 00:00:00
abstract：:To investigate the function of SWI/SNF in site-specific chromatin remodeling at promoters, we have used a purified system to analyze its distribution, function, and retention following recruitment by a sequence-specific transcription activator. Activator recruitment of SWI/SNF bound the complex to promoter proximal nu...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(01)00279-3
更新日期：2001-03-23 00:00:00
abstract：:As in eukaryotes, bacterial genomes are not randomly folded. Bacterial genetic information is generally carried on a circular chromosome with a single origin of replication from which two replication forks proceed bidirectionally toward the opposite terminus region. Here, we investigate the higher-order architecture o...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2017.12.027
更新日期：2018-02-08 00:00:00
abstract：:Pathogenic Vibrio cholerae remains a major human health concern. V. cholerae has a characteristic curved rod morphology, with a longer outer face and a shorter inner face. The mechanism and function of this curvature were previously unknown. Here, we identify and characterize CrvA, the first curvature determinant in V...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2016.12.019
更新日期：2017-01-12 00:00:00
abstract：:Enhancers provide critical information directing cell-type-specific transcriptional programs, regulated by binding of signal-dependent transcription factors and their associated cofactors. Here, we report that the most strongly activated estrogen (E2)-responsive enhancers are characterized by trans-recruitment and in ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2014.08.027
更新日期：2014-10-09 00:00:00
abstract：:Academic travel has a substantial carbon footprint. The ongoing pandemic has propelled the development and adoption of technologies for online delivery of seminars and remote attendance at scientific conferences. This should not lead to the complete elimination of in-person events, but the scientific community must se...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2020.07.026
更新日期：2020-08-20 00:00:00
abstract：:Social impairment is frequently associated with mitochondrial dysfunction and altered neurotransmission. Although mitochondrial function is crucial for brain homeostasis, it remains unknown whether mitochondrial disruption contributes to social behavioral deficits. Here, we show that Drosophila mutants in the homolog ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2020.02.044
更新日期：2020-03-19 00:00:00
abstract：:Chromosomal rearrangements, including translocations, require formation and joining of DNA double strand breaks (DSBs). These events disrupt the integrity of the genome and are frequently involved in producing leukemias, lymphomas and sarcomas. Despite the importance of these events, current understanding of their gen...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2011.07.048
更新日期：2011-09-30 00:00:00
abstract：:The crystal structure of the Src SH2 domain complexed with a high affinity 11-residue phosphopeptide has been determined at 2.7 A resolution by X-ray diffraction. The peptide binds in an extended conformation and makes primary interactions with the SH2 domain at six central residues: PQ(pY)EEI. The phosphotyrosine and...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(93)90405-f
更新日期：1993-03-12 00:00:00
abstract：:Of the several families of adhesion receptors involved in leukocyte-endothelial cell interactions, only the selectins have been shown to initiate leukocyte interaction under physiologic shear; indeed, beta 2 (CD18) intergrins responsible for neutrophil arrest are unable to engage without prior selectin-mediated rollin...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(95)90491-3
更新日期：1995-02-10 00:00:00
abstract：:We have determined the high resolution crystal structure of the A domain from the alpha chain of integrin CR3. The domain adopts a classic alpha/beta "Rossmann" fold and contains an unusual Mg2+ coordination site at its surface. One of the coordinating ligands is the glutamate side chain from another A domain molecule...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(95)90517-0
更新日期：1995-02-24 00:00:00
abstract：:Certain tRNAs in S. cerevisiae (tRNATyr and tRNAPhe) arise via precursor molecules which are mature at the 5' and 3' termini but contain intervening sequences adjacent to the anticodon (Knapp et al., 1978; O'Farrell et al., 1978). In addition to these molecules, precursors to several other tRNAs accumulate in a temper...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(79)90349-0
更新日期：1979-09-01 00:00:00
abstract：:Exposure to Mycobacterium tuberculosis produces varied early outcomes, ranging from resistance to infection to progressive disease. Here we report results from a forward genetic screen in zebrafish larvae that identify multiple mutant classes with distinct patterns of innate susceptibility to Mycobacterium marinum. A ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2010.02.013
更新日期：2010-03-05 00:00:00
abstract：:Immune homeostasis in the intestine involves complex interactions between microbial organisms and host cells. In this issue, Garrett et al. (2007) describe a communicable form of colitis that is induced by deficiency of the transcription factor T-bet in cells of the innate immune system. ...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2007.09.030
更新日期：2007-10-05 00:00:00
abstract：:Mutations at the mouse tottering (tg) locus cause a delayed-onset, recessive neurological disorder resulting in ataxia, motor seizures, and behavioral absence seizures resembling petit mal epilepsy in humans. A more severe allele, leaner (tg(la)), also shows a slow, selective degeneration of cerebellar neurons. By pos...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)81381-1
更新日期：1996-11-15 00:00:00
abstract：:Spotted fever group (SFG) rickettsiae are human pathogens that infect cells in the vasculature. They disseminate through host tissues by a process of cell-to-cell spread that involves protrusion formation, engulfment, and vacuolar escape. Other bacterial pathogens rely on actin-based motility to provide a physical for...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2016.09.023
更新日期：2016-10-20 00:00:00
abstract：:The COVID-19 pandemic has led to extensive morbidity and mortality throughout the world. Clinical features that drive SARS-CoV-2 pathogenesis in humans include inflammation and thrombosis, but the mechanistic details underlying these processes remain to be determined. In this study, we demonstrate endothelial disrupti...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2020.10.005
更新日期：2020-11-25 00:00:00
abstract：:The p53 tumor suppressor gene is commonly altered in human tumors, predominantly through missense mutations that result in accumulation of mutant p53 protein. These mutations may confer dominant-negative or gain-of-function properties to p53. To ascertain the physiological effects of p53 point mutation, the structural...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2004.11.004
更新日期：2004-12-17 00:00:00
abstract：:The looming threat of a new influenza virus pandemic has fueled ambitious efforts to devise more predictive parameters for assessing the risks associated with emergent virus strains. At the same time, a comprehensive understanding of critical factors that can accurately predict the outcome of vaccination is sorely nee...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2014.03.023
更新日期：2014-04-10 00:00:00
abstract：:We performed a comprehensive assessment of rare inherited variation in autism spectrum disorder (ASD) by analyzing whole-genome sequences of 2,308 individuals from families with multiple affected children. We implicate 69 genes in ASD risk, including 24 passing genome-wide Bonferroni correction and 16 new ASD risk gen...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2019.07.015
更新日期：2019-08-08 00:00:00
abstract：:The mesenchymal-amoeboid transition (MAT) was proposed as a mechanism for cancer cells to adapt their migration mode to their environment. While the molecular pathways involved in this transition are well documented, the role of the microenvironment in the MAT is still poorly understood. Here, we investigated how conf...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2015.01.007
更新日期：2015-02-12 00:00:00
abstract：:A clonally diverse anticipatory repertoire in which each lymphocyte bears a unique antigen receptor is the central feature of the adaptive immune system that evolved in our vertebrate ancestors. The survival advantage gained through adding this type of adaptive immune system to a pre-existing innate immune system led ...
journal_title：Cell
pub_type： 杂志文章,评审
doi：10.1016/j.cell.2006.02.001
更新日期：2006-02-24 00:00:00
abstract：:Phage G1 gp67 is a 23 kDa protein that binds to the Staphylococcus aureus (Sau) RNA polymerase (RNAP) σ(A) subunit and blocks cell growth by inhibiting transcription. We show that gp67 has little to no effect on transcription from most promoters but is a potent inhibitor of ribosomal RNA transcription. A 2.0-Å-resolut...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2012.10.034
更新日期：2012-11-21 00:00:00
abstract：:The haywire gene of Drosophila encodes a protein with 66% identity to the product of the human ERCC3 gene, associated with xeroderma pigmentosum B (XP-B) and Cockayne's syndrome (CS). XP is a human autosomal recessive disease characterized by extreme sensitivity to ultraviolet irradiation and marked susceptibility to ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(92)90389-t
更新日期：1992-12-11 00:00:00
abstract：:Among its multiple functions, p53 is a critical regulator of TGF-beta responses. Sasai et al. (2008) now identify a new p53 inhibitory protein, XFDL156. During embryonic development, this factor is expressed in the ectoderm germ layer and maintains the pluripotency of ectodermal cells by inhibiting TGF-beta target gen...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2008.05.013
更新日期：2008-05-30 00:00:00
abstract：:We have identified and analyzed a meiotic reciprocal recombination hot spot in S. cerevisiae. We find that double-strand breaks occur at two specific sites associated with the hot spot and that occurrence of these breaks depends upon meiotic recombination functions RAD50 and SPO11. Furthermore, these breaks occur in a...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(90)90072-m
更新日期：1990-06-15 00:00:00
