Abstract：
:The phosphoinositide 3-kinase related kinases (PIKKs) mediate responses to diverse stresses, including DNA double-strand breaks (DSBs), abnormal replication fork progression, the recognition of premature termination codons in mRNAs, and inadequate nutrient availability. Rigorous control of these kinases limits cellular damage and promotes cell viability in the presence of stress. Control mechanisms include the localization of PIKKs into multiprotein complexes at the sites of damage and mediation of protein-protein contacts such that substrates are allowed access to the PIKK catalytic domains.
journal_name
Celljournal_title
Cellauthors
Bakkenist CJ,Kastan MBdoi
10.1016/j.cell.2004.06.023subject
Has Abstractpub_date
2004-07-09 00:00:00pages
9-17issue
1eissn
0092-8674issn
1097-4172pii
S0092867404006166journal_volume
118pub_type
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