Abstract:
:It is unknown whether the activity of the nervous system can be inherited. In Caenorhabditis elegans nematodes, parental responses can transmit heritable small RNAs that regulate gene expression transgenerationally. In this study, we show that a neuronal process can impact the next generations. Neurons-specific synthesis of RDE-4-dependent small RNAs regulates germline amplified endogenous small interfering RNAs (siRNAs) and germline gene expression for multiple generations. Further, the production of small RNAs in neurons controls the chemotaxis behavior of the progeny for at least three generations via the germline Argonaute HRDE-1. Among the targets of these small RNAs, we identified the conserved gene saeg-2, which is transgenerationally downregulated in the germline. Silencing of saeg-2 following neuronal small RNA biogenesis is required for chemotaxis under stress. Thus, we propose a small-RNA-based mechanism for communication of neuronal processes transgenerationally.
journal_name
Celljournal_title
Cellauthors
Posner R,Toker IA,Antonova O,Star E,Anava S,Azmon E,Hendricks M,Bracha S,Gingold H,Rechavi Odoi
10.1016/j.cell.2019.04.029subject
Has Abstractpub_date
2019-06-13 00:00:00pages
1814-1826.e15issue
7eissn
0092-8674issn
1097-4172pii
S0092-8674(19)30448-9journal_volume
177pub_type
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