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Blinded by the Light: The Growing Complexity of p53.

Abstract：

:While the tumor suppressor functions of p53 have long been recognized, the contribution of p53 to numerous other aspects of disease and normal life is only now being appreciated. This burgeoning range of responses to p53 is reflected by an increasing variety of mechanisms through which p53 can function, although the ability to activate transcription remains key to p53's modus operandi. Control of p53's transcriptional activity is crucial for determining which p53 response is activated, a decision we must understand if we are to exploit efficiently the next generation of drugs that selectively activate or inhibit p53.

journal_name

Cell

journal_title

Cell

authors

Vousden KH,Prives C

doi

10.1016/j.cell.2009.04.037

subject

Has Abstract

pub_date

2009-05-01 00:00:00

pages

413-31

issue

3

eissn

0092-8674

issn

1097-4172

pii

S0092-8674(09)00459-0

journal_volume

137

pub_type

杂志文章,评审

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