Abstract：
:It has been long appreciated that, during meiosis, DNA replication is coordinated with the subsequent formation of the double-strand breaks (DSBs) that initiate recombination, but a mechanistic understanding of this process was elusive. We now show that, in yeast, the replisome-associated components Tof1 and Csm3 physically associate with the Dbf4-dependent Cdc7 kinase (DDK) and recruit it to the replisome, where it phosphorylates the DSB-promoting factor Mer2 in the wake of the replication fork, synchronizing replication with an early prerequisite for DSB formation. Recruiting regulatory kinases to replisomes may be a general mechanism to ensure spatial and temporal coordination of replication with other chromosomal processes.
journal_name
Celljournal_title
Cellauthors
Murakami H,Keeney Sdoi
10.1016/j.cell.2014.06.028subject
Has Abstractpub_date
2014-08-14 00:00:00pages
861-873issue
4eissn
0092-8674issn
1097-4172pii
S0092-8674(14)00819-8journal_volume
158pub_type
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