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Pushing and pulling in prokaryotic DNA segregation.

Abstract：

:In prokaryotes, DNA can be segregated by three different types of cytoskeletal filaments. The best-understood type of partitioning (par) locus encodes an actin homolog called ParM, which forms dynamically unstable filaments that push plasmids apart in a process reminiscent of mitosis. However, the most common type of par locus, which is present on many plasmids and most bacterial chromosomes, encodes a P loop ATPase (ParA) that distributes plasmids equidistant from one another on the bacterial nucleoid. A third type of par locus encodes a tubulin homolog (TubZ) that forms cytoskeletal filaments that move rapidly with treadmill dynamics.

journal_name

Cell

journal_title

Cell

authors

Gerdes K,Howard M,Szardenings F

doi

10.1016/j.cell.2010.05.033

subject

Has Abstract

pub_date

2010-06-11 00:00:00

pages

927-42

issue

6

eissn

0092-8674

issn

1097-4172

pii

S0092-8674(10)00569-6

journal_volume

141

pub_type

杂志文章,评审

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