METTL13 Methylation of eEF1A Increases Translational Output to Promote Tumorigenesis.

abstract：:Nucleosomes help structure chromosomes by compacting DNA into fibers. To gain insight into how nucleosomes are arranged in vivo, we combined quantitative super-resolution nanoscopy with computer simulations to visualize and count nucleosomes along the chromatin fiber in single nuclei. Nucleosomes assembled in heteroge...

journal_title：Cell

authors： Ricci MA,Manzo C,García-Parajo MF,Lakadamyali M,Cosma MP

更新日期：2015-03-12 00:00:00

abstract：:Receptor dimerization is ubiquitous to the action of all receptor tyrosine kinases, and in the case of dimeric ligands, such as the stem cell factor (SCF), it was attributed to ligand bivalency. However, by using a dimerization-inhibitory monoclonal antibody to the SCF receptor, we confined a putative dimerization sit...

journal_title：Cell

authors： Blechman JM,Lev S,Barg J,Eisenstein M,Vaks B,Vogel Z,Givol D,Yarden Y

更新日期：1995-01-13 00:00:00

abstract：:Eukaryotic cells sterilize the cytosol by using autophagy to route invading bacterial pathogens to the lysosome. During macrophage infection with Mycobacterium tuberculosis, a vacuolar pathogen, exogenous induction of autophagy can limit replication, but the mechanism of autophagy targeting and its role in natural inf...

journal_title：Cell

authors： Watson RO,Manzanillo PS,Cox JS

更新日期：2012-08-17 00:00:00

abstract：:Symbiotic bacteria are important in animal hosts, but have been largely overlooked as they have proved difficult to culture in the laboratory. Approaches such as comparative genomics and real-time PCR have provided insights into the molecular mechanisms that underpin symbiont-host interactions. Studies on the heritabl...

journal_title：Cell

authors： Dale C,Moran NA

更新日期：2006-08-11 00:00:00

abstract：:Sterol regulatory element binding proteins (SREBPs) are transcription factors attached to the endoplasmic reticulum. The NH2-segment, which activates transcription, is connected to membranes by a hairpin anchor formed by two transmembrane sequences and a short lumenal loop. Using H-Ras-SREBP-2 fusion proteins, we show...

journal_title：Cell

authors： Sakai J,Duncan EA,Rawson RB,Hua X,Brown MS,Goldstein JL

更新日期：1996-06-28 00:00:00

abstract：:Metastasis is a rare event. Does it arise from rare, variant, highly metastatic cells or does a primary tumor progress to a premalignant state from which metastases arise stochastically without further changes in gene expression? Arguments and evidence have been adduced to support either position. A paper in this mont...

journal_title：Cell

authors： Hynes RO

更新日期：2003-06-27 00:00:00

abstract：:We have generated mice carrying a germline mutation in the tyrosine kinase catalytic domain of the trkB gene. This mutation eliminates expression of gp145trkB, a protein-tyrosine kinase that serves as the signaling receptor for two members of the nerve growth factor family of neurotrophins, brain-derived neurotrophic ...

journal_title：Cell

authors： Klein R,Smeyne RJ,Wurst W,Long LK,Auerbach BA,Joyner AL,Barbacid M

更新日期：1993-10-08 00:00:00

abstract：:Many proteins contain disordered regions of low-sequence complexity, which cause aging-associated diseases because they are prone to aggregate. Here, we study FUS, a prion-like protein containing intrinsically disordered domains associated with the neurodegenerative disease ALS. We show that, in cells, FUS forms liqui...

journal_title：Cell

authors： Patel A,Lee HO,Jawerth L,Maharana S,Jahnel M,Hein MY,Stoynov S,Mahamid J,Saha S,Franzmann TM,Pozniakovski A,Poser I,Maghelli N,Royer LA,Weigert M,Myers EW,Grill S,Drechsel D,Hyman AA,Alberti S

更新日期：2015-08-27 00:00:00

abstract：:The protein product of the human Duchenne muscular dystrophy locus (DMD) and its mouse homolog (mDMD) have been identified by using polyclonal antibodies directed against fusion proteins containing two distinct regions of the mDMD cDNA. The DMD protein is shown to be approximately 400 kd and to represent approximately...

journal_title：Cell

authors： Hoffman EP,Brown RH Jr,Kunkel LM

更新日期：1987-12-24 00:00:00

abstract：:The intestinal epithelium is a highly structured tissue composed of repeating crypt-villus units. Enterocytes perform the diverse tasks of absorbing a wide range of nutrients while protecting the body from the harsh bacterium-rich environment. It is unknown whether these tasks are spatially zonated along the villus ax...

journal_title：Cell

authors： Moor AE,Harnik Y,Ben-Moshe S,Massasa EE,Rozenberg M,Eilam R,Bahar Halpern K,Itzkovitz S

更新日期：2018-11-01 00:00:00

abstract：:The 5' terminal structure of the mRNA synthesized in vitro by the virion-associated RNA polymerase of vesicular stomatitis virus in the presence of S-adenosyl-L-methione consists of 7-methyl guanosine linked to 2'-O-methyl adenosine through a 5'-5' pyrophosphate bond as m7G(5')ppp(5')A-m-p ... The alpha and beta phosp...

journal_title：Cell

authors： Abraham G,Rhodes DP,Banerjee AK

更新日期：1975-05-01 00:00:00

abstract：:The 2013-2015 West African epidemic of Ebola virus disease (EVD) reminds us of how little is known about biosafety level 4 viruses. Like Ebola virus, Lassa virus (LASV) can cause hemorrhagic fever with high case fatality rates. We generated a genomic catalog of almost 200 LASV sequences from clinical and rodent reserv...

journal_title：Cell

authors： Andersen KG,Shapiro BJ,Matranga CB,Sealfon R,Lin AE,Moses LM,Folarin OA,Goba A,Odia I,Ehiane PE,Momoh M,England EM,Winnicki S,Branco LM,Gire SK,Phelan E,Tariyal R,Tewhey R,Omoniwa O,Fullah M,Fonnie R,Fonnie M,

更新日期：2015-08-13 00:00:00

abstract：:A novel method of affinity chromatography on insolubilized collagen-binding fragments of fibronectin was utilized to isolate a random-coil collagenous protein from culture media of mouse teratocarcinoma-derived endodermal cells. These cells also produced another collagenous protein, which did not bind to fibronectin b...

journal_title：Cell

authors： Engvall E,Bell ML,Carlsson RN,Miller EJ,Ruoslahti E

更新日期：1982-06-01 00:00:00

abstract：:Coordinated organ behavior is crucial for an effective response to environmental stimuli. By studying regeneration of hair follicles in response to patterned hair plucking, we demonstrate that organ-level quorum sensing allows coordinated responses to skin injury. Plucking hair at different densities leads to a regene...

journal_title：Cell

authors： Chen CC,Wang L,Plikus MV,Jiang TX,Murray PJ,Ramos R,Guerrero-Juarez CF,Hughes MW,Lee OK,Shi S,Widelitz RB,Lander AD,Chuong CM

更新日期：2015-04-09 00:00:00

abstract：:The S. cerevisiae gene MCR1 encodes two mitochondrial isoforms of NADH-cytochrome b5 reductase. The primary translation product has an amino-terminal matrix-targeting signal, followed by a stretch of 21 uncharged amino acids. This precursor protein is inserted into the outer membrane, but only about one-third of the m...

journal_title：Cell

authors： Hahne K,Haucke V,Ramage L,Schatz G

更新日期：1994-12-02 00:00:00

abstract：:Acquisition of the intestinal microbiota begins at birth, and a stable microbial community develops from a succession of key organisms. Disruption of the microbiota during maturation by low-dose antibiotic exposure can alter host metabolism and adiposity. We now show that low-dose penicillin (LDP), delivered from birt...

journal_title：Cell

authors： Cox LM,Yamanishi S,Sohn J,Alekseyenko AV,Leung JM,Cho I,Kim SG,Li H,Gao Z,Mahana D,Zárate Rodriguez JG,Rogers AB,Robine N,Loke P,Blaser MJ

更新日期：2014-08-14 00:00:00

abstract：:The science advisor to the US president has the opportunity to influence how scientific research is supported by the federal government, as well as the ways in which science and technology can be applied to meet the needs of society. ...

journal_title：Cell

authors： Lane NF,Matthews KR

更新日期：2009-11-25 00:00:00

abstract：:DNA interstrand crosslinks (ICLs) are toxic DNA lesions whose repair occurs in the S phase of metazoans via an unknown mechanism. Here, we describe a cell-free system based on Xenopus egg extracts that supports ICL repair. During DNA replication of a plasmid containing a site-specific ICL, two replication forks conver...

journal_title：Cell

authors： Räschle M,Knipscheer P,Enoiu M,Angelov T,Sun J,Griffith JD,Ellenberger TE,Schärer OD,Walter JC

更新日期：2008-09-19 00:00:00

abstract：:In yeast, hyperosmotic stress causes an immediate dissociation of most proteins from chromatin, presumably because cells are unprepared for, and initially unresponsive to, increased ion concentrations in the nucleus. Osmotic stress activates Hog1 MAP kinase, which phosphorylates at least two proteins located at the pl...

journal_title：Cell

authors： Proft M,Struhl K

更新日期：2004-08-06 00:00:00

abstract：:Axonal transport has been intensively examined as a good model for studying the mechanism of organelle transport in cells, but it is still unclear how different types of membrane organelles are transported through the nerve axon. To elucidate the function of this mechanism, we have cloned KIF1A, a novel neuron-specifi...

journal_title：Cell

authors： Okada Y,Yamazaki H,Sekine-Aizawa Y,Hirokawa N

更新日期：1995-06-02 00:00:00

abstract：:Ebola virus (EBOV) remains a public health threat. We performed a longitudinal study of B cell responses to EBOV in four survivors of the 2014 West African outbreak. Infection induced lasting EBOV-specific immunoglobulin G (IgG) antibodies, but their subclass composition changed over time, with IgG1 persisting, IgG3 r...

journal_title：Cell

authors： Davis CW,Jackson KJL,McElroy AK,Halfmann P,Huang J,Chennareddy C,Piper AE,Leung Y,Albariño CG,Crozier I,Ellebedy AH,Sidney J,Sette A,Yu T,Nielsen SCA,Goff AJ,Spiropoulou CF,Saphire EO,Cavet G,Kawaoka Y,Mehta AK,

更新日期：2019-05-30 00:00:00

abstract：:Inositol phosphates are well-known signaling molecules, whereas the inositol pyrophosphates, such as diphosphoinositol pentakisphosphate (InsP7/IP7) and bis-diphosphoinositol tetrakisphosphate (InsP8/IP8), are less well characterized. We demonstrate physiologic regulation of Dictyostelium chemotaxis by InsP7 mediated ...

journal_title：Cell

authors： Luo HR,Huang YE,Chen JC,Saiardi A,Iijima M,Ye K,Huang Y,Nagata E,Devreotes P,Snyder SH

更新日期：2003-09-05 00:00:00

abstract：:A new class of endogenous primate type C virus has been isolated from a continuous tissue culture line of Macaca arctoides cells by co-cultivation with a human cell line. The virus, designated MAC-1, can be transmitted to human and feline cells in tissue culture, and is unrelated, by immunological and nucleic acid hyb...

journal_title：Cell

authors： Todaro GJ,Benveniste RE,Sherwin SA,Sherr CJ

更新日期：1978-04-01 00:00:00

abstract：:The complete sequence of a hemagglutinin (HA) gene of a recent human influenza A strain, A/Victoria/3/75, is 1768 nucleotides long and contains the information for 567 amino acids. It codes for a signal peptide of 16 amino acids, the HA1 chain of the mature hemagglutinin of 329 amino acids, a connecting region between...

journal_title：Cell

authors： Jou WM,Verhoeyen M,Devos R,Saman E,Fang R,Huylebroeck D,Fiers W,Threlfall G,Barber C,Carey N,Emtage S

更新日期：1980-03-01 00:00:00

abstract：:Mutants in bacterial topoisomerase (topo) IV are deficient in chromosomal partitioning. To investigate the basis of this phenotype, we examined plasmid DNA topology in conditionally lethal topo IV mutants. We found that dimeric catenated plasmids accumulated in vivo after topo IV inhibition. The catenanes were superco...

journal_title：Cell

authors： Adams DE,Shekhtman EM,Zechiedrich EL,Schmid MB,Cozzarelli NR

更新日期：1992-10-16 00:00:00

abstract：:We have examined the long-range distribution of double-stranded DNA cleavage sites for Drosophila melanogaster topoisomerase II. These studies reveal a novel partitioning of preferred topoisomerase II cleavage sites. In the eukaryotic DNAs examined, major cleavage sites were typically found in nontranscribed spacer se...

journal_title：Cell

authors： Udvardy A,Schedl P,Sander M,Hsieh TS

更新日期：1985-04-01 00:00:00

abstract：:Nucleotide sequences in two wild-type and six mutant operators in the DNA of phage lambda are compared. Strikingly similar 17 base pair units are found which we identify as the repressor binding sites. Each operator contains multiple repressor binding sites separated by A-T rich spacers. Elements of 2 fold rotational ...

journal_title：Cell

authors： Maniatis T,Ptashne M,Backman K,Kield D,Flashman S,Jeffrey A,Maurer R

更新日期：1975-06-01 00:00:00

abstract：:Hox homeodomain proteins are developmental regulators that determine body plan in a variety of organisms. A majority of the vertebrate Hox proteins bind DNA as heterodimers with the Pbx1 homeodomain protein. We report here the 2.35 A structure of a ternary complex containing a human HoxB1-Pbx1 heterodimer bound to DNA...

journal_title：Cell

authors： Piper DE,Batchelor AH,Chang CP,Cleary ML,Wolberger C

更新日期：1999-02-19 00:00:00

abstract：:We describe automated technologies to probe the structure of neural tissue at nanometer resolution and use them to generate a saturated reconstruction of a sub-volume of mouse neocortex in which all cellular objects (axons, dendrites, and glia) and many sub-cellular components (synapses, synaptic vesicles, spines, spi...

journal_title：Cell

authors： Kasthuri N,Hayworth KJ,Berger DR,Schalek RL,Conchello JA,Knowles-Barley S,Lee D,Vázquez-Reina A,Kaynig V,Jones TR,Roberts M,Morgan JL,Tapia JC,Seung HS,Roncal WG,Vogelstein JT,Burns R,Sussman DL,Priebe CE,Pfister H

更新日期：2015-07-30 00:00:00

abstract：:Telomerase activity was demonstrated in cell-free extracts from S. cerevisiae through the use of a PCR-based assay. As expected, this activity was eliminated by RNase or phenol treatment of the extract and was dependent on dGTP and dTTP. Telomerase was not detected in extracts prepared from cells grown for approximate...

journal_title：Cell

authors： Lin JJ,Zakian VA

更新日期：1995-06-30 00:00:00