Abstract:
:We have examined the long-range distribution of double-stranded DNA cleavage sites for Drosophila melanogaster topoisomerase II. These studies reveal a novel partitioning of preferred topoisomerase II cleavage sites. In the eukaryotic DNAs examined, major cleavage sites were typically found in nontranscribed spacer segments and close to the 5' and 3' boundaries of genes. In contrast, there were few if any prominent cleavage sites within genes. In addition, most of the major topoisomerase II cleavage sites closely corresponded to naked DNA hypersensitive sites for the prokaryotic enzyme, micrococcal nuclease.
journal_name
Celljournal_title
Cellauthors
Udvardy A,Schedl P,Sander M,Hsieh TSdoi
10.1016/0092-8674(85)90353-8subject
Has Abstractpub_date
1985-04-01 00:00:00pages
933-41issue
4eissn
0092-8674issn
1097-4172pii
0092-8674(85)90353-8journal_volume
40pub_type
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