A chromosome RNAissance.

abstract：:X inactivation results in inactivation of one X chromosome to compensate for gene dosage differences between mammalian females and males. It requires the X-inactivation center (Xic) and Xist in cis. We report that introducing 450 kb of murine Xic/Xist sequences onto autosomes activates female dosage compensation in ma...

journal_title：Cell

authors： Lee JT,Strauss WM,Dausman JA,Jaenisch R

更新日期：1996-07-12 00:00:00

abstract：:Previous experiments have shown that mRNA translation in frog oocytes can be inhibited by the injection of a complementary antisense RNA. Here we explore the use of antisense RNAs to study the functions of localized maternal mRNAs during postfertilization development. While developmental abnormalities were observed in...

journal_title：Cell

authors： Rebagliati MR,Melton DA

更新日期：1987-02-27 00:00:00

abstract：:During membrane fusion, the outer leaflets of the two membranes merge first, whereas the distal membrane leaflets remain separate until the opening of a fusion pore. This intermediate stage, called hemifusion, is a critical event shared by exocytosis, protein trafficking, and viral entry. ...

journal_title：Cell

authors： Chernomordik LV,Kozlov MM

更新日期：2005-11-04 00:00:00

abstract：:Determining which neurite of a differentiating neuron is to become the axon is a crucial step in neuronal morphogenesis. Two groups (Barnes et al., 2007; Shelly et al., 2007) now report that axon specification in vivo is mediated by extracellular signals acting through the serine/threonine kinase LKB1. ...

journal_title：Cell

authors： Winckler B

更新日期：2007-05-04 00:00:00

abstract：:The lin-12 gene of C. elegans and the Notch gene of D. melanogaster encode structurally related transmembrane proteins that mediate intercellular signaling. We show that truncated forms of these proteins consisting of only the intracellular domains cause cell fate transformations associated with constitutive activity ...

journal_title：Cell

authors： Struhl G,Fitzgerald K,Greenwald I

更新日期：1993-07-30 00:00:00

abstract：:Sucrose gradient analysis of DNA isolated from detergent-pronase lysates of adult flies has been used to look for ribosomal genes not integrated into the DNA of the chromosome in genotypes containing various combinations of inversions having breakpoints in the proximal heterochromatin of the X chromosome. Unintegrated...

journal_title：Cell

authors： Harford AG,Zuchowski CI

更新日期：1977-06-01 00:00:00

abstract：:Chemotherapy results in a frequent yet poorly understood syndrome of long-term neurological deficits. Neural precursor cell dysfunction and white matter dysfunction are thought to contribute to this debilitating syndrome. Here, we demonstrate persistent depletion of oligodendrocyte lineage cells in humans who received...

journal_title：Cell

authors： Gibson EM,Nagaraja S,Ocampo A,Tam LT,Wood LS,Pallegar PN,Greene JJ,Geraghty AC,Goldstein AK,Ni L,Woo PJ,Barres BA,Liddelow S,Vogel H,Monje M

更新日期：2019-01-10 00:00:00

abstract：:Hsp33, a member of a newly discovered heat shock protein family, was found to be a very potent molecular chaperone. Hsp33 is distinguished from all other known molecular chaperones by its mode of functional regulation. Its activity is redox regulated. Hsp33 is a cytoplasmically localized protein with highly reactive c...

journal_title：Cell

authors： Jakob U,Muse W,Eser M,Bardwell JC

更新日期：1999-02-05 00:00:00

abstract：:We have reproduced the posttranslational mode of protein translocation across the endoplasmic reticulum membrane with reconstituted proteoliposomes containing a purified complex of seven yeast proteins. This Sec complex includes a heterotrimeric Sec61p complex, homologous to that in mammals, as well as all other membr...

journal_title：Cell

authors： Panzner S,Dreier L,Hartmann E,Kostka S,Rapoport TA

更新日期：1995-05-19 00:00:00

abstract：:Protein-protein interaction maps provide a valuable framework for a better understanding of the functional organization of the proteome. To detect interacting pairs of human proteins systematically, a protein matrix of 4456 baits and 5632 preys was screened by automated yeast two-hybrid (Y2H) interaction mating. We id...

journal_title：Cell

authors： Stelzl U,Worm U,Lalowski M,Haenig C,Brembeck FH,Goehler H,Stroedicke M,Zenkner M,Schoenherr A,Koeppen S,Timm J,Mintzlaff S,Abraham C,Bock N,Kietzmann S,Goedde A,Toksöz E,Droege A,Krobitsch S,Korn B,Birchmeier W,

更新日期：2005-09-23 00:00:00

abstract：:An injection of aphidicolin into early Drosophila embryos inhibits DNA synthesis and nuclear division, while centrosome replication and many other aspects of the mitotic cycle continue. If aphidicolin is injected at nuclear cycle 7-8, the normal migration of nuclei to the embryo cortex is completely inhibited. In most...

journal_title：Cell

authors： Raff JW,Glover DM

更新日期：1989-05-19 00:00:00

abstract：:The brain produces two brain-derived neurotrophic factor (BDNF) transcripts, with either short or long 3' untranslated regions (3' UTRs). The physiological significance of the two forms of mRNAs encoding the same protein is unknown. Here, we show that the short and long 3' UTR BDNF mRNAs are involved in different cell...

journal_title：Cell

authors： An JJ,Gharami K,Liao GY,Woo NH,Lau AG,Vanevski F,Torre ER,Jones KR,Feng Y,Lu B,Xu B

更新日期：2008-07-11 00:00:00

abstract：:The human immunodeficiency virus, the lentivirus that causes AIDS, is responsible for the most prevalent epidemic in the history of mankind. Here in this Timeline, we have attempted to illustrate a short history of HIV-1, from its identification in landmark papers published by Robert Gallo, Myron Essex, and Luc Montag...

journal_title：Cell

authors： Agarwal-Jans S

更新日期：2020-10-15 00:00:00

abstract：:Nine transcripts complementary to mouse L cell mitochondrial DNA have been detected, sized and mapped to restriction fragments using the method of Berk and Sharp (1977). RNA isolated from L cell mitochondria was hybridized to 32P-labeled, cloned L cell mitochondrial DNA restriction fragments in 70% formamide under con...

journal_title：Cell

authors： Battey J,Clayton DA

更新日期：1978-05-01 00:00:00

abstract：:How chaperonins orchestrate the successful folding of even the most elaborate of proteins is a question of central importance. In two recent studies in Cell by Joachimiak et al. and Freund et al., a new class of TRiC substrate is identified, and how the chaperonin exploits its different subunits to extend its substrat...

journal_title：Cell

authors： Zhuravleva A,Radford SE

更新日期：2014-12-04 00:00:00

abstract：:We have developed an in vitro system utilizing yeast cell-free extracts to catalyze recombination events between homologous plasmids containing different mutant alleles of the Tet or ARG4 genes. The reaction increased the frequency of Tcr or Arg+ transformants (recombinants) from 2 X 10(-6) to 1-3 X 10(-3). Linearizin...

journal_title：Cell

authors： Symington LS,Fogarty LM,Kolodner R

更新日期：1983-12-01 00:00:00

abstract：:Using cryo-electron microscopy, we have solved the structure of an icosidodecahedral COPII coat involved in cargo export from the endoplasmic reticulum (ER) coassembled from purified cargo adaptor Sec23-24 and Sec13-31 lattice-forming complexes. The coat structure shows a tetrameric assembly of the Sec23-24 adaptor la...

journal_title：Cell

authors： Stagg SM,LaPointe P,Razvi A,Gürkan C,Potter CS,Carragher B,Balch WE

更新日期：2008-08-08 00:00:00

abstract：:We have established the DNA sequence of nine yeast mutants that prevent the expression either of the split cytochrome b gene alone (five mutants) or of two split genes, the cytochrome b gene and the cytochrome oxidase subunit I gene (four mutants). All the mutations analyzed are localized in intron 14 of the cob-box g...

journal_title：Cell

authors： De La Salle H,Jacq C,Slonimski PP

更新日期：1982-04-01 00:00:00

abstract：:The DDB1-CUL4-RBX1 (CRL4) ubiquitin ligase family regulates a diverse set of cellular pathways through dedicated substrate receptors (DCAFs). The DCAF DDB2 detects UV-induced pyrimidine dimers in the genome and facilitates nucleotide excision repair. We provide the molecular basis for DDB2 receptor-mediated cyclobutan...

journal_title：Cell

authors： Fischer ES,Scrima A,Böhm K,Matsumoto S,Lingaraju GM,Faty M,Yasuda T,Cavadini S,Wakasugi M,Hanaoka F,Iwai S,Gut H,Sugasawa K,Thomä NH

更新日期：2011-11-23 00:00:00

abstract：:We mutated, by gene targeting, the endogenous hypoxanthine phosphoribosyl transferase (HPRT) gene in mouse embryo-derived stem (ES) cells. A specialized construct of the neomycin resistance (neor) gene was introduced into an exon of a cloned fragment of the Hprt gene and used to transfect ES cells. Among the G418r col...

journal_title：Cell

authors： Thomas KR,Capecchi MR

更新日期：1987-11-06 00:00:00

abstract：:The classical model for the activation of the nucleotide exchange factor Son of sevenless (SOS) involves its recruitment to the membrane, where it engages Ras. The recent discovery that Ras*GTP is an allosteric activator of SOS indicated that the regulation of SOS is more complex than originally envisaged. We now pres...

journal_title：Cell

authors： Sondermann H,Soisson SM,Boykevisch S,Yang SS,Bar-Sagi D,Kuriyan J

更新日期：2004-10-29 00:00:00

abstract：:Cellular functioning requires the orchestration of thousands of molecular interactions in time and space. Yet most molecules in a cell move by diffusion, which is sensitive to external factors like temperature. How cells sustain complex, diffusion-based systems across wide temperature ranges is unknown. Here, we uncov...

journal_title：Cell

authors： Persson LB,Ambati VS,Brandman O

更新日期：2020-12-10 00:00:00

abstract：:In the SV40-transformed mouse embryo fibroblast cell line SVT2/S, genomic rearrangements involving the SV40 DNA and flanking host sequences were identified by Southern blot hybridization using viral DNA as probe. No rearrangements of SV40 DNA integrated into nonpermissive mouse cells have been previously described. Th...

journal_title：Cell

authors： Sager R,Anisowicz A,Howell N

更新日期：1981-01-01 00:00:00

abstract：:The transport kinetics of the influenza virus hemagglutinin from its site of synthesis to the apical plasma membrane of Madin-Darby canine kidney cells, a polarized epithelial cell line, were studied by a sensitive tryptic assay. Hemagglutinin acquired terminal sugars, as judged by sensitivity to endo-beta-N-acetylglu...

journal_title：Cell

authors： Matlin KS,Simons K

更新日期：1983-08-01 00:00:00

abstract：:The therapeutic value of DNA-damaging antineoplastic agents is dependent upon their ability to induce tumor cell apoptosis while sparing most normal tissues. Here, we show that a component of the apoptotic response to these agents in several different types of tumor cells is the deamidation of two asparagines in the u...

journal_title：Cell

authors： Deverman BE,Cook BL,Manson SR,Niederhoff RA,Langer EM,Rosová I,Kulans LA,Fu X,Weinberg JS,Heinecke JW,Roth KA,Weintraub SJ

更新日期：2002-10-04 00:00:00

abstract：:Sirtuins are thought to form crucial links between energy levels and cellular metabolism. Libert et al. now provide evidence that SIRT1 activity in the brain modifies mammalian emotional behavior via monoamine signaling and that changes in this pathway might contribute to human affective disorders. ...

journal_title：Cell

authors： Drew LJ,Hen R

更新日期：2011-12-23 00:00:00

abstract：:The science advisor to the US president has the opportunity to influence how scientific research is supported by the federal government, as well as the ways in which science and technology can be applied to meet the needs of society. ...

journal_title：Cell

authors： Lane NF,Matthews KR

更新日期：2009-11-25 00:00:00

abstract：:Mutations in the single-minded (sim) gene of Drosophila result in the loss of the precursor cells giving rise to the midline cells of the embryonic central nervous system. We have examined the structure of the sim product by sequencing a sim cDNA clone, and have also determined the subcellular localization of the prot...

journal_title：Cell

authors： Crews ST,Thomas JB,Goodman CS

更新日期：1988-01-15 00:00:00

abstract：:Condensin protein complexes coordinate the formation of mitotic chromosomes and thereby ensure the successful segregation of replicated genomes. Insights into how condensin complexes bind to chromosomes and alter their topology are essential for understanding the molecular principles behind the large-scale chromatin r...

journal_title：Cell

authors： Kschonsak M,Merkel F,Bisht S,Metz J,Rybin V,Hassler M,Haering CH

更新日期：2017-10-19 00:00:00

abstract：:The 5' terminal structure of the mRNA synthesized in vitro by the virion-associated RNA polymerase of vesicular stomatitis virus in the presence of S-adenosyl-L-methione consists of 7-methyl guanosine linked to 2'-O-methyl adenosine through a 5'-5' pyrophosphate bond as m7G(5')ppp(5')A-m-p ... The alpha and beta phosp...

journal_title：Cell

authors： Abraham G,Rhodes DP,Banerjee AK

更新日期：1975-05-01 00:00:00