Abstract：
:Secreted proteins of the Wnt family have profound organizing roles during animal development and are transduced via the activities of the Frizzled (Fz) class of transmembrane receptors and the TCF/LEF/Pangolin class of transcription factors. beta-catenins, including Drosophila Armadillo (Arm), link activation of Fz at the cell surface to transcriptional regulation by TCF in the nucleus. The consensus view is that Wnt signaling induces beta-catenin to enter the nucleus and combine with TCF to form a transcription factor complex in which TCF binds DNA and the C-terminal domain of beta-catenin activates transcription. Here, we present findings, which challenge this view and suggest instead that beta-catenin may transduce Wnt signals by exporting TCF from the nucleus or activating it in the cytoplasm.
journal_name
Celljournal_title
Cellauthors
Chan SK,Struhl Gdoi
10.1016/s0092-8674(02)01037-1subject
Has Abstractpub_date
2002-10-18 00:00:00pages
265-80issue
2eissn
0092-8674issn
1097-4172pii
S0092867402010371journal_volume
111pub_type
杂志文章,收录出版相关文献
CELL文献大全abstract：:Specification of the germ cell lineage is vital to development and heredity. In mice, the germ cell fate is induced in pluripotent epiblast cells by signaling molecules, yet the underlying mechanism remains unknown. Here we demonstrate that germ cell fate in the epiblast is a direct consequence of Bmp4 signaling from ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2009.03.014
更新日期：2009-05-01 00:00:00
abstract：:In this issue of Cell, Lee et al. (2006) report that the parasite Trypanosoma brucei synthesizes fatty acids in an unconventional way. T. brucei and two other trypanosomes use enzymes called elongases to synthesize myristate, a fourteen carbon (C14) fatty acid essential for pathogenesis. This is an unexpected finding ...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2006.08.001
更新日期：2006-08-25 00:00:00
abstract：:Fragile X syndrome, a common form of inherited intellectual disability, is caused by loss of the fragile X mental retardation protein FMRP. FMRP is present predominantly in the cytoplasm, where it regulates translation of proteins that are important for synaptic function. We identify FMRP as a chromatin-binding protei...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2014.03.040
更新日期：2014-05-08 00:00:00
abstract：:The mitochondrial unfolded protein response (UPRmt) can be triggered in a cell-non-autonomous fashion across multiple tissues in response to mitochondrial dysfunction. The ability to communicate information about the presence of mitochondrial stress enables a global response that can ultimately better protect an organ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2018.06.029
更新日期：2018-08-09 00:00:00
abstract：:The C-terminal domain (CTD) of the largest subunit of yeast RNA polymerase II contains 26-27 tandem copies of a conserved heptapeptide of unknown function. Yeast strains whose CTD contains ten heptamers are viable but defective for transcription of the INO1 gene and cold sensitive for growth. Deletion of the SIN1 gene...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(91)90268-4
更新日期：1991-03-22 00:00:00
abstract：:Tracing the lineage history of cells is key to answering diverse and fundamental questions in biology. Coupling of cell ancestry information with other molecular readouts represents an important goal in the field. Here, we describe the CRISPR array repair lineage tracing (CARLIN) mouse line and corresponding analysis ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2020.04.048
更新日期：2020-06-11 00:00:00
abstract：:Leukocyte adhesion deficiency (LAD) is a heritable disease involving deficient expression of three related leukocyte adhesion glycoproteins: LFA-1, Mac-1, and p150,95. These proteins are alpha beta heterodimers containing identical 95,000 dalton beta subunits. Here we demonstrate that the primary defect in LAD is in t...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(87)90215-7
更新日期：1987-07-17 00:00:00
abstract：:The Ras GTPase links extracellular mitogens to intracellular mechanisms that control cell proliferation. To understand how Ras regulates proliferation in vivo, we activated or inactivated Ras in cell clones in the developing Drosophila wing. Cells lacking Ras were smaller, had reduced growth rates, accumulated in G1, ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)80679-0
更新日期：2000-02-18 00:00:00
abstract：:During development, sensory axons compete for limiting neurotrophic support, and local neurotrophin insufficiency triggers caspase-dependent axon degeneration. The signaling driving axon degeneration upon local deprivation is proposed to reside within axons. Our results instead support a model in which, despite the ap...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2016.01.032
更新日期：2016-02-25 00:00:00
abstract：:Reactivation of human cytomegalovirus (HCMV) results in severe disease in AIDS patients and immunocompromised patients receiving blood transfusions or organ or bone marrow grafts. Although the site of HCMV latency is unknown, blood cells have been implicated as a viral reservoir. In this study, we demonstrate HCMV rea...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(01)80014-3
更新日期：1997-10-03 00:00:00
abstract：:The synthesis and secretion of plasminogen activator by cultured macrophages can be induced and stimulated by concanavalin A and by phorbol myristate acetate, and inhibited by such agents as glucocorticoids, mitotic inhibitors and compounds affecting cAMP metabolism. By the manipulation of stimulatory and inhibitory i...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(77)90086-1
更新日期：1977-07-01 00:00:00
abstract：:Screens for agents that specifically kill epithelial cancer stem cells (CSCs) have not been possible due to the rarity of these cells within tumor cell populations and their relative instability in culture. We describe here an approach to screening for agents with epithelial CSC-specific toxicity. We implemented this ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2009.06.034
更新日期：2009-08-21 00:00:00
abstract：:Acquisition of the ability to produce and respond to a growth factor may result in increased cellular proliferation and could lead to malignant transformation. The fact that a large variety of tumor cells secrete transforming growth factor-alpha (TGF-alpha) suggests involvement of TGF-alpha in cellular transformation ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(86)90747-6
更新日期：1986-07-18 00:00:00
abstract：:The global rise in the prevalence of obesity and associated co-morbidities such as type 2 diabetes, cardiovascular disease, and cancer represents a major public health concern. The biological response to increased consumption of palatable foods or a reduction in energy expenditure is highly variable between individual...
journal_title：Cell
pub_type： 杂志文章,评审
doi：10.1016/j.cell.2015.03.008
更新日期：2015-03-26 00:00:00
abstract：:Sexual reproduction is almost universal in eukaryotic life and involves the fusion of male and female haploid gametes into a diploid cell. The sperm-restricted single-pass transmembrane protein HAP2-GCS1 has been postulated to function in membrane merger. Its presence in the major eukaryotic taxa-animals, plants, and ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2017.01.024
更新日期：2017-02-23 00:00:00
abstract：:Trigger factor is a soluble, 63,000 dalton protein of E. coli that stabilizes proOmpA, the precursor form of a major outer-membrane protein, in a conformation competent for in vitro membrane assembly. There is approximately one trigger factor molecule bound to each 70S ribosome isolated from cell extracts in physiolog...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(88)90116-x
更新日期：1988-09-23 00:00:00
abstract：:The chronic autoimmune diseases include multiple complex genetic disorders. Recently, genome-wide association studies (GWAS) have identified a large number of major loci, with many associations shared between various autoimmune diseases. These associations highlight key roles for lymphocyte activation and prioritize s...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2010.03.003
更新日期：2010-03-19 00:00:00
abstract：:To determine whether phylogenetically conservative H-Y antigen plays any part in gonadal differentiation among the nonmammalian vertebrates, we studied expression and binding of H-Y in the frog, Xenopus laevis. Soluble H-Y obtained from mouse testis and soluble H-W from chicken ovary bound specifically to cells of the...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(80)90332-3
更新日期：1980-07-01 00:00:00
abstract：:Newly synthesized transcripts are usually spliced during transcription or immediately thereafter. So pre-mRNA splicing has been presumed to occur exclusively in the cell nucleus. In this issue of Cell, Denis et al. (2005) now report the presence of functional spliceosomes and signal-dependent pre-mRNA splicing in the ...
journal_title：Cell
pub_type： 评论,杂志文章,评审
doi：10.1016/j.cell.2005.07.016
更新日期：2005-08-12 00:00:00
abstract：:The accurate timing and execution of organelle biogenesis is crucial for cell physiology. Centriole biogenesis is regulated by Polo-like kinase 4 (Plk4) and initiates in S-phase when a daughter centriole grows from the side of a pre-existing mother. Here, we show that a Plk4 oscillation at the base of the growing cent...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2020.05.018
更新日期：2020-06-25 00:00:00
abstract：:Potassium channels embedded in cell membranes employ gates to regulate K+ current. While a specific constriction in the permeation pathway has historically been implicated in gating, recent reports suggest that the signature ion selectivity filter located in the outer membrane leaflet may be equally important. Inwardl...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2010.05.003
更新日期：2010-06-11 00:00:00
abstract：:Designing successful microbiota-based therapies requires in-depth understanding of the ecological foundations of this community. In this issue, two studies by Whitaker et al. and Lim et al. provide refined genetic tools for dissecting the spatial organization and temporal dynamics of bacterial communities at the singl...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2017.04.009
更新日期：2017-04-20 00:00:00
abstract：:The central vasculature of plant roots is protected by a hydrophobic ring of endodermal cells that are enclosed by lamellae of suberin. Barberon et al. demonstrate that endodermal suberization plasticity facilitates ion homeostasis, with antithetical regulation of suberin deposition and degradation by the phytohormone...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2016.01.005
更新日期：2016-01-28 00:00:00
abstract：:The monoclonal antibody ECCD-1 inhibits Ca2+-dependent cell-cell adhesion in teratocarcinoma cells, recognizing a cell surface component of MW 124,000. When mouse embryos at various preimplantation stages were cultured in the presence of ECCD-1, the compacted morphology of the 8- to 16-cell-stage embryos was destroyed...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(83)90095-8
更新日期：1983-12-01 00:00:00
abstract：:Synergistic bispecific antibodies against HIV exhibit extraordinary potency and breadth of neutralization as promising candidates for treatment and prevention. ...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2016.06.004
更新日期：2016-06-16 00:00:00
abstract：:We have transferred the mouse Ak alpha and Ak beta genes, which encode the class II I-Ak molecule, into mouse L-cell fibroblasts and hamster B cells. I-Ak molecules are expressed on the surface of both cell types. The L-cell and hamster B-cell I-Ak molecules appear normal by serological analyses and two-dimensional ge...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(84)90225-3
更新日期：1984-02-01 00:00:00
abstract：:The protein product of the human Duchenne muscular dystrophy locus (DMD) and its mouse homolog (mDMD) have been identified by using polyclonal antibodies directed against fusion proteins containing two distinct regions of the mDMD cDNA. The DMD protein is shown to be approximately 400 kd and to represent approximately...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(87)90579-4
更新日期：1987-12-24 00:00:00
abstract：:Recent work has identified a mouse gene (tsg101) whose inactivation in fibroblasts results in cellular transformation and the ability to produce metastatic tumors in nude mice. Here, we report that the human homolog, TSG101, which we isolated and mapped to chromosome 11, bands 15.1-15.2, a region proposed to contain t...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)81866-8
更新日期：1997-01-10 00:00:00
abstract：:Vertebrate Hoxd genes are sequentially activated during the morphogenesis and pattern formation of the limb. Using the approach of gene disruption via homologous recombination in embryonic stem cells, we have assessed the function of the last gene of the complex, Hoxd-13. Mutant mice displayed skeletal alterations alo...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(93)90378-4
更新日期：1993-11-05 00:00:00
abstract：:The Brachyury (T) gene is required for mesoderm formation in the mouse. In this paper we describe the cloning and expression of a Xenopus homolog of Brachyury, Xbra. As with Brachyury in the mouse, Xbra is expressed in presumptive mesodermal cells around the blastopore, and then in the notochord. We show that expressi...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(91)90573-h
更新日期：1991-10-04 00:00:00
