xol-1 acts as an early switch in the C. elegans male/hermaphrodite decision.

abstract：:We have cloned a Dictyostelium phosphotyrosine phosphatase (PTP1) with a catalytic domain showing approximately 38%-50% amino acid identity to those of other PTPs. PTP1 contains an approximately 99 amino acid insert and bacterially produced PTP1 possesses PTP activity. PTP1 is expressed at a very low level in vegetati...

journal_title：Cell

authors： Howard PK,Sefton BM,Firtel RA

更新日期：1992-11-13 00:00:00

abstract：:We report that the 12,000 dalton domain of fibronectin that interacts with fibroblast cell surfaces also binds specifically to thrombin-inducible, saturable receptors on platelets. Furthermore, we have used chemical cross-linking and monoclonal antibodies to show that the 12,000 dalton domain of fibronectin interacts ...

journal_title：Cell

authors： Gardner JM,Hynes RO

更新日期：1985-09-01 00:00:00

abstract：:Rapid flow of information in the nervous system involves presynaptic vesicle recycling by clathrin-mediated endocytosis, an event triggered by the alpha-adaptin-containing AP2 complex. We identified a Drosophila alpha-adaptin expressed in the garland cells, imaginal discs, and the CNS. Here we show its role in presyna...

journal_title：Cell

authors： González-Gaitán M,Jäckle H

更新日期：1997-03-21 00:00:00

abstract：:Mitochondrial respiratory-chain complexes assemble from subunits of dual genetic origin assisted by specialized assembly factors. Whereas core subunits are translated on mitochondrial ribosomes, others are imported after cytosolic translation. How imported subunits are ushered to assembly intermediates containing mito...

journal_title：Cell

authors： Mick DU,Dennerlein S,Wiese H,Reinhold R,Pacheu-Grau D,Lorenzi I,Sasarman F,Weraarpachai W,Shoubridge EA,Warscheid B,Rehling P

更新日期：2012-12-21 00:00:00

abstract：:The structure and organization on the Escherichia coli chromosome of the gene cluster coding for two methionine tRNAs (tRNAmMet), four glutamine tRNAs (two tRNA1Gln and two tRNA2Gln), and a previously unidentified tRNA (called tRNAx) have been studied by restriction enzyme analysis and DNA sequencing, utilizing a spec...

journal_title：Cell

authors： Nakajima N,Ozeki H,Shimura Y

更新日期：1981-01-01 00:00:00

abstract：:The existence of pseudogenes and the observation of intron loss suggest that RNA can serve as an intermediate in recombination. We used a HIS3 reporter gene to show that RNA-mediated recombination occurs in yeast. His3+ prototroph formation required transcription and expression of the retrotransposon Ty. Two RNA-media...

journal_title：Cell

authors： Derr LK,Strathern JN,Garfinkel DJ

更新日期：1991-10-18 00:00:00

abstract：:We show that a functional component of the C. elegans mitotic machinery regulates X chromosome gene expression. This protein, MIX-1, is a member of the dosage compensation complex that associates specifically with hermaphrodite X chromosomes to reduce their gene expression during interphase. MIX-1 also associates with...

journal_title：Cell

authors： Lieb JD,Albrecht MR,Chuang PT,Meyer BJ

更新日期：1998-01-23 00:00:00

abstract：:A 57 kd component of oligosaccharyl transferase, termed glycosylation site binding protein, specifically recognizes a photoaffinity probe containing the N-glycosylation site sequence Asn-Lys-Thr. It is present in the lumen of the ER (endoplasmic reticulum) and its release from this compartment results in a loss of N-g...

journal_title：Cell

authors： Geetha-Habib M,Noiva R,Kaplan HA,Lennarz WJ

更新日期：1988-09-23 00:00:00

abstract：:Recent studies have revealed that multiple intracellular signaling proteins may assemble into structured, yet sometimes infinite, higher-order signaling machines for transmission of receptor activation information to cellular responses. These studies advance our understanding of cell signaling and implicate new molecu...

journal_title：Cell

authors： Wu H

更新日期：2013-04-11 00:00:00

abstract：:The tyrT locus of E. coli contains a 208 bp spacer region that separates two copies of sequence encoding tRNATyr1. The spacer includes a 120 bp sequence that is homologous to a sequence that is repeated three times in the distal portion of the tyrT locus. The tyrT locus possesses a graded set of transcription terminat...

journal_title：Cell

authors： Rossi J,Egan J,Hudson L,Landy A

更新日期：1981-11-01 00:00:00

abstract：:Three different cases of pancreatic beta cell hyperplasia in mice are accompanied by an increase in a subclass of cells expressing tyrosine hydroxylase (TH), a neuronal enzyme. In the nontumorigenic cases of islet growth during normal pregnancy and in the obese mutant mouse, the TH-insulin cells do not divide, in cont...

journal_title：Cell

authors： Teitelman G,Alpert S,Hanahan D

更新日期：1988-01-15 00:00:00

abstract：:Suppressor of Hairless (Su(H)) is required at two stages of adult sensory organ development in Drosophila. Complete loss of Su(H) function results in a "neurogenic" phenotype in imaginal discs, in which too many cells adopt the sensory organ precursor cell fate. Su(H) is also involved in controlling the fates of sensi...

journal_title：Cell

authors： Schweisguth F,Posakony JW

更新日期：1992-06-26 00:00:00

abstract：:DDB1, a component of the Cul4 ubiquitin ligase complex, promotes protein ubiquitination in diverse cellular functions, including nuclear excision repair, regulation of the cell cycle, and DNA replication. To investigate its physiological significance, we generated mice with null and floxed alleles of the DDB1 gene. He...

journal_title：Cell

authors： Cang Y,Zhang J,Nicholas SA,Bastien J,Li B,Zhou P,Goff SP

更新日期：2006-12-01 00:00:00

abstract：:Adenovirus E1B 19 kDa protein protects against cell death induced by viral infection and certain external stimuli. The Bcl-2 protein can functionally substitute for the E1B 19 kDa protein. To identify cellular targets for the 19 kDa protein, we used the two-hybrid screen in yeast. We have isolated cDNAs for three diff...

journal_title：Cell

authors： Boyd JM,Malstrom S,Subramanian T,Venkatesh LK,Schaeper U,Elangovan B,D'Sa-Eipper C,Chinnadurai G

更新日期：1994-10-21 00:00:00

abstract：:Temperature compensation of circadian clocks is an unsolved problem with relevance to the general phenomenon of biological compensation. We identify casein kinase 2 (CK2) as a key regulator of temperature compensation of the Neurospora clock by determining that two long-standing clock mutants, chrono and period-3, dis...

journal_title：Cell

authors： Mehra A,Shi M,Baker CL,Colot HV,Loros JJ,Dunlap JC

更新日期：2009-05-15 00:00:00

abstract：:A family of novel substrates was designed to enable the efficient accumulation of intermediates in site-specific recombination. Strategically placed nicks allow these "suicide substrates" to initiate the reaction but prevent its completion or reversal. Consequently, it has been possible to determine that lambda site-s...

journal_title：Cell

authors： Nunes-Düby SE,Matsumoto L,Landy A

更新日期：1987-08-28 00:00:00

abstract：:A transglutaminase-catalyzed cross-linking process characteristic of keratinocytes leads to the formation of the insoluble corneocyte envelope. The essentials of this process take place in vitro in a reconstituted system derived from subcellular fractions. A particulate fraction containing membrane-bound envelope prec...

journal_title：Cell

authors： Simon M,Green H

更新日期：1985-03-01 00:00:00

abstract：:Accurately predicting an outcome requires that animals learn supporting and conflicting evidence from sequential experience. In mammals and invertebrates, learned fear responses can be suppressed by experiencing predictive cues without punishment, a process called memory extinction. Here, we show that extinction of av...

journal_title：Cell

authors： Felsenberg J,Jacob PF,Walker T,Barnstedt O,Edmondson-Stait AJ,Pleijzier MW,Otto N,Schlegel P,Sharifi N,Perisse E,Smith CS,Lauritzen JS,Costa M,Jefferis GSXE,Bock DD,Waddell S

更新日期：2018-10-18 00:00:00

abstract：:Drosophila chorion genes are located in two clusters, one on the X chromosome at 7F1-2 of the polytene chromosome map and a second on the third chromosome at 66D11-15. Genes in both regions undergo amplification in ovarian follicle cells prior to their expression late in oogenesis. Analysis of cloned genomic segments ...

journal_title：Cell

authors： Spradling AC

更新日期：1981-11-01 00:00:00

abstract：:The general inhibition in transcriptional activity during mitosis abolishes the stress-inducible expression of the human hsp70 gene. Among the four transcription factors that bind to the human hsp70 promoter, the DNA-binding activities of three (C/EBP, GBP, and HSF1) were normal, while Sp1 showed reduced binding activ...

journal_title：Cell

authors： Martínez-Balbás MA,Dey A,Rabindran SK,Ozato K,Wu C

更新日期：1995-10-06 00:00:00

abstract：:Using insertional mutagenesis, we have isolated a "stalky" mutant in which cells destined to become spores end up as stalk cells. Similar mutants were previously observed after chemical mutagenesis, but the affected gene could not be isolated. Our mutant, like the previous ones, is in stkA. Its defect is cell-autonomo...

journal_title：Cell

authors： Chang WT,Newell PC,Gross JD

更新日期：1996-11-01 00:00:00

abstract：:Regeneration of transected peripheral nerves is a complex process involving the coordinated action of neuronal axons, glial cells, and fibroblasts. Using rodent models of nerve repair, Parrinello et al. (2010) find that ephrin signaling between fibroblasts and Schwann cell progenitors, involving the stemness factor So...

journal_title：Cell

authors： Klein R

更新日期：2010-10-01 00:00:00

abstract：:The role of electricity in biological systems was first appreciated through electrical stimulation experiments performed by Luigi Galvani in the 18th century. These pioneering experiments demonstrated that the behavior of living tissues is governed by the flow of electrochemical species-an insight that gave rise to th...

journal_title：Cell

authors： Lee DD,Prindle A,Liu J,Süel GM

更新日期：2017-06-29 00:00:00

abstract：:Short DNA chains, isolated from in vitro pulse-labeled replicating polyoma DNA, exhibit some degree of self-complementarity (28% resistance to S1 nuclease after self-annealing to plateau levels). This level of self-annealing is not increased if short DNA chains present as free single-stranded DNA after extraction are ...

journal_title：Cell

authors： Francke B,Vogt M

更新日期：1975-06-01 00:00:00

abstract：:Social isolation is a stressful condition that often leads to maladaptive behaviors. In this issue of Cell, Zelikowsky et al. find that chronic social isolation stress triggers an increase in neuronal tachykinin signaling across distinct brain regions that mediate fear and aggression, elucidating the neural basis of t...

journal_title：Cell

authors： Rodriguez-Romaguera J,Stuber GD

更新日期：2018-05-17 00:00:00

abstract：:A single mouse blastomere from an embryo until the 8-cell stage can generate an entire blastocyst. Whether laboratory-cultured cells retain a similar generative capacity remains unknown. Starting from a single stem cell type, extended pluripotent stem (EPS) cells, we established a 3D differentiation system that enable...

journal_title：Cell

authors： Li R,Zhong C,Yu Y,Liu H,Sakurai M,Yu L,Min Z,Shi L,Wei Y,Takahashi Y,Liao HK,Qiao J,Deng H,Nuñez-Delicado E,Rodriguez Esteban C,Wu J,Izpisua Belmonte JC

更新日期：2019-10-17 00:00:00

abstract：:The sequence of about one third of the polyoma virus genome is presented. This sequence covers the origin of replication of two large plaque strains (A2 and A3) of polyoma virus. The two strains differ by 11 bp in the origin region. A model for replication is suggested. The sequence probably also covers the entire cod...

journal_title：Cell

authors： Soeda E,Arrand JR,Smolar N,Griffin BE

更新日期：1979-06-01 00:00:00

abstract：:Signaling by the epidermal growth factor receptor requires an allosteric interaction between the kinase domains of two receptors, whereby one activates the other. We show that the intracellular juxtamembrane segment of the receptor, known to potentiate kinase activity, is able to dimerize the kinase domains. The C-ter...

journal_title：Cell

authors： Jura N,Endres NF,Engel K,Deindl S,Das R,Lamers MH,Wemmer DE,Zhang X,Kuriyan J

更新日期：2009-06-26 00:00:00

abstract：:Pancreatic beta cell-surface expression of glucose transporter 2 (Glut-2) is essential for glucose-stimulated insulin secretion, thereby controlling blood glucose homeostasis in response to dietary intake. We show that the murine GlcNAcT-IVa glycosyltransferase is required for Glut-2 residency on the beta cell surface...

journal_title：Cell

authors： Ohtsubo K,Takamatsu S,Minowa MT,Yoshida A,Takeuchi M,Marth JD

更新日期：2005-12-29 00:00:00

abstract：:We performed a comprehensive assessment of rare inherited variation in autism spectrum disorder (ASD) by analyzing whole-genome sequences of 2,308 individuals from families with multiple affected children. We implicate 69 genes in ASD risk, including 24 passing genome-wide Bonferroni correction and 16 new ASD risk gen...

journal_title：Cell

authors： Ruzzo EK,Pérez-Cano L,Jung JY,Wang LK,Kashef-Haghighi D,Hartl C,Singh C,Xu J,Hoekstra JN,Leventhal O,Leppä VM,Gandal MJ,Paskov K,Stockham N,Polioudakis D,Lowe JK,Prober DA,Geschwind DH,Wall DP

更新日期：2019-08-08 00:00:00