Generation of Blastocyst-like Structures from Mouse Embryonic and Adult Cell Cultures.

abstract：:The MAVS protein plays a critical role in the assembly of an antiviral signaling complex on mitochondrial membranes. Hou et al. (2011) now report that virus infection induces a conformational change in MAVS, leading to the prion-like formation of functional self-aggregates that provide a sensitive trigger for antivira...

journal_title：Cell

authors： Ye J,Maniatis T

更新日期：2011-08-05 00:00:00

abstract：:Human hepatitis B virus core protein expressed in E. coli assembles into two sizes of particle. We have determined their three-dimensional structures by electron cryomicroscopy and image processing. The large and small particles correspond to triangulation number T = 4 and T = 3 dimer clustered packings, containing 24...

journal_title：Cell

authors： Crowther RA,Kiselev NA,Böttcher B,Berriman JA,Borisova GP,Ose V,Pumpens P

更新日期：1994-06-17 00:00:00

abstract：:Determining which neurite of a differentiating neuron is to become the axon is a crucial step in neuronal morphogenesis. Two groups (Barnes et al., 2007; Shelly et al., 2007) now report that axon specification in vivo is mediated by extracellular signals acting through the serine/threonine kinase LKB1. ...

journal_title：Cell

authors： Winckler B

更新日期：2007-05-04 00:00:00

abstract：:The 5' terminal sequences of several adenovirus 2 (Ad2) mRNAs, isolated late in infection, are complementary to sequences within the Ad2 genome which are remote from the DNA from which the main coding sequence of each mRNA is transcribed. This has been observed by forming RNA displacement loops (R loops) between Ad2 D...

journal_title：Cell

authors： Chow LT,Gelinas RE,Broker TR,Roberts RJ

更新日期：1977-09-01 00:00:00

abstract：:The auditory inner hair cell (IHC) ribbon synapse operates with an exceptional temporal precision and maintains a high level of neurotransmitter release. However, the molecular mechanisms underlying IHC synaptic exocytosis are largely unknown. We studied otoferlin, a predicted C2-domain transmembrane protein, which is...

journal_title：Cell

authors： Roux I,Safieddine S,Nouvian R,Grati M,Simmler MC,Bahloul A,Perfettini I,Le Gall M,Rostaing P,Hamard G,Triller A,Avan P,Moser T,Petit C

更新日期：2006-10-20 00:00:00

abstract：:The hallmarks of cancer comprise six biological capabilities acquired during the multistep development of human tumors. The hallmarks constitute an organizing principle for rationalizing the complexities of neoplastic disease. They include sustaining proliferative signaling, evading growth suppressors, resisting cell ...

journal_title：Cell

authors： Hanahan D,Weinberg RA

更新日期：2011-03-04 00:00:00

abstract：:The HVEM (TNFRSF14) receptor gene is among the most frequently mutated genes in germinal center lymphomas. We report that loss of HVEM leads to cell-autonomous activation of B cell proliferation and drives the development of GC lymphomas in vivo. HVEM-deficient lymphoma B cells also induce a tumor-supportive microenvi...

journal_title：Cell

authors： Boice M,Salloum D,Mourcin F,Sanghvi V,Amin R,Oricchio E,Jiang M,Mottok A,Denis-Lagache N,Ciriello G,Tam W,Teruya-Feldstein J,de Stanchina E,Chan WC,Malek SN,Ennishi D,Brentjens RJ,Gascoyne RD,Cogné M,Tarte K,Wende

更新日期：2016-10-06 00:00:00

abstract：:The 75 kDa tumor necrosis factor receptor (TNFR2) transduces extracellular signals via receptor-associated cytoplasmic proteins. Two of these signal transducers, TRAF1 and TRAF2, were isolated and characterized previously. We report here the biochemical purification and subsequent molecular cloning of two novel TNFR2-...

journal_title：Cell

authors： Rothe M,Pan MG,Henzel WJ,Ayres TM,Goeddel DV

更新日期：1995-12-29 00:00:00

abstract：:Primary cilium dysfunction underlies the pathogenesis of Bardet-Biedl syndrome (BBS), a genetic disorder whose symptoms include obesity, retinal degeneration, and nephropathy. However, despite the identification of 12 BBS genes, the molecular basis of BBS remains elusive. Here we identify a complex composed of seven h...

journal_title：Cell

authors： Nachury MV,Loktev AV,Zhang Q,Westlake CJ,Peränen J,Merdes A,Slusarski DC,Scheller RH,Bazan JF,Sheffield VC,Jackson PK

更新日期：2007-06-15 00:00:00

abstract：:We describe the purification and characterization of ACF, an ATP-utilizing chromatin assembly and remodeling factor. ACF is a multisubunit factor that contains ISWI protein and is distinct from NURF, another ISWI-containing factor. In chromatin assembly, purified ACF and a core histone chaperone (such as NAP-1 or CAF-...

journal_title：Cell

authors： Ito T,Bulger M,Pazin MJ,Kobayashi R,Kadonaga JT

更新日期：1997-07-11 00:00:00

abstract：:The triskelion shape of the clathrin molecule enables it to form the polyhedral protein network that covers clathrin-coated pits and vesicles. Domains within the clathrin heavy chain that are responsible for maintaining triskelion shape and function were identified and localized. Sequences that mediate trimerization a...

journal_title：Cell

authors： Näthke IS,Heuser J,Lupas A,Stock J,Turck CW,Brodsky FM

更新日期：1992-03-06 00:00:00

abstract：:How is the characteristic shape of an organelle generated? Recent work has provided insight into how the tubular network of the endoplasmic reticulum (ER) is formed. The tubules themselves are shaped by the reticulons and DP1/Yop1p, whereas their fusion into a network is brought about by membrane-bound GTPases that in...

journal_title：Cell

authors： Hu J,Prinz WA,Rapoport TA

更新日期：2011-12-09 00:00:00

abstract：:Nucleosome assembly following DNA replication and gene transcription is important to maintain genome stability and epigenetic information. Newly synthesized histones H3-H4 first bind histone chaperone Asf1 and are then transferred to other chaperones for nucleosome assembly. However, it is unknown how H3-H4 is transfe...

journal_title：Cell

authors： Han J,Zhang H,Zhang H,Wang Z,Zhou H,Zhang Z

更新日期：2013-11-07 00:00:00

abstract：:After three or more passages, stromal cell outgrowths from explants of normal rabbit corneas and from corneas previously burned with alkali did not produce collagenase until they were stimulated by the addition of rabbit blood-derived mononuclear cells or media conditioned by them. Normal stromal cells required stimul...

journal_title：Cell

authors： Newsome DA,Gross J

更新日期：1979-04-01 00:00:00

abstract：:Salmonella enterica invasion of host cells requires the reversible activation of the Rho-family GTPases Cdc42 and Rac1 by the bacterially encoded GEF SopE and the GAP SptP, which exert their function at different times during infection and are delivered into host cells by a type III secretion system. We found that Sop...

journal_title：Cell

authors： Kubori T,Galán JE

更新日期：2003-10-31 00:00:00

abstract：:The hsp 70 gene of Drosophila contains three domains to which a heat shock gene specific transcription factor (HSTF) binds. In addition to the previously described 55 bp binding domain proximal to the TAT homology, there are two 25 bp binding sites farther upstream. Footprinting studies with 5' and 3' deletion mutatio...

journal_title：Cell

authors： Topol J,Ruden DM,Parker CS

更新日期：1985-09-01 00:00:00

abstract：:Potassium is an essential mineral element for plant growth and development. Although it is known that plants absorb and transport K+ through membrane transporters, it remains unclear how these transporters are regulated. Here we show that the protein kinase CIPK23, encoded by the LKS1 gene, regulates K+ uptake under l...

journal_title：Cell

authors： Xu J,Li HD,Chen LQ,Wang Y,Liu LL,He L,Wu WH

更新日期：2006-06-30 00:00:00

abstract：:DNA repair is an essential process for preserving genome integrity in all organisms. In eukaryotes, recombinational repair is choreographed by multiprotein complexes that are organized into centers (foci). Here, we analyze the cellular response to DNA double-strand breaks (DSBs) and replication stress in Saccharomyces...

journal_title：Cell

authors： Lisby M,Barlow JH,Burgess RC,Rothstein R

更新日期：2004-09-17 00:00:00

abstract：:Transfer of human chromosome 11, which contains the myoD locus, from primary fibroblasts into 10T1/2 cells results in activation of myoD. In contrast, hybrids that retain human chromosome 11 and additional human chromosomes fail to activate myoD. We show that human chromosome 4 inhibits myoD activation. myoD enhancer/...

journal_title：Cell

authors： Woloshin P,Song K,Degnin C,Killary AM,Goldhamer DJ,Sassoon D,Thayer MJ

更新日期：1995-08-25 00:00:00

abstract：:Balancing the capacity for protein maturation with changes in protein flux through the endoplasmic reticulum (ER) is crucial for maintaining ER homeostasis. In this issue, Merksamer et al. (2008) exploit a redox-sensitive fluorescent protein to monitor the environment inside the ER of living yeast, illuminating how th...

journal_title：Cell

authors： Kang SW,Hegde RS

更新日期：2008-11-28 00:00:00

abstract：:Affordable genome sequencing technologies promise to revolutionize the field of human genetics by enabling comprehensive studies that interrogate all classes of genome variation, genome-wide, across the entire allele frequency spectrum. Ongoing projects worldwide are sequencing many thousands-and soon millions-of huma...

journal_title：Cell

authors： Lappalainen T,Scott AJ,Brandt M,Hall IM

更新日期：2019-03-21 00:00:00

abstract：:Fertilized clam embryos synthesize several new cell-cycle-related proteins. The cloned cDNA and derived amino acid sequences of one of these, cyclin A, are presented here. Immunoblots with an anti-cyclin A antibody reveal that cyclin A is undetectable in oocytes, appears within 15 min of fertilization, and is destroye...

journal_title：Cell

authors： Swenson KI,Farrell KM,Ruderman JV

更新日期：1986-12-26 00:00:00

abstract：:Expression of pipe in the somatic tissue of the Drosophila ovary is required for the formation of embryonic dorsal-ventral polarity. pipe, which encodes an enzyme similar to the glycosaminoglycan-modifying enzyme heparan sulfate 2-O-sulfotransferase, is expressed in a spatially restricted domain of follicle cells on t...

journal_title：Cell

authors： Sen J,Goltz JS,Stevens L,Stein D

更新日期：1998-11-13 00:00:00

abstract：:Biomechanical stress is a major stimulus for cardiac hypertrophy and the transition to heart failure. By generating mice that harbor a ventricular restricted knockout of the gp130 cytokine receptor via Cre-IoxP-mediated recombination, we demonstrate a critical role for a gp130-dependent myocyte survival pathway in the...

journal_title：Cell

authors： Hirota H,Chen J,Betz UA,Rajewsky K,Gu Y,Ross J Jr,Müller W,Chien KR

更新日期：1999-04-16 00:00:00

abstract：:Rodent cells resistant to PALA, a specific inhibitor of the aspartate transcarbamylase activity of the multifunctional CAD protein, overproduce CAD as a result of amplification of the CAD gene. We cloned a functional CAD gene from Syrian hamster cells using a cosmid vector. Two independently isolated cosmids containin...

journal_title：Cell

authors： de Saint Vincent BR,Delbrück S,Eckhart W,Meinkoth J,Vitto L,Wahl G

更新日期：1981-12-01 00:00:00

abstract：:The intestinal epithelium is a highly structured tissue composed of repeating crypt-villus units. Enterocytes perform the diverse tasks of absorbing a wide range of nutrients while protecting the body from the harsh bacterium-rich environment. It is unknown whether these tasks are spatially zonated along the villus ax...

journal_title：Cell

authors： Moor AE,Harnik Y,Ben-Moshe S,Massasa EE,Rozenberg M,Eilam R,Bahar Halpern K,Itzkovitz S

更新日期：2018-11-01 00:00:00

abstract：:Protein aggregation is linked with neurodegeneration and numerous other diseases by mechanisms that are not well understood. Here, we have analyzed the gain-of-function toxicity of artificial β sheet proteins that were designed to form amyloid-like fibrils. Using quantitative proteomics, we found that the toxicity of ...

journal_title：Cell

authors： Olzscha H,Schermann SM,Woerner AC,Pinkert S,Hecht MH,Tartaglia GG,Vendruscolo M,Hayer-Hartl M,Hartl FU,Vabulas RM

更新日期：2011-01-07 00:00:00

abstract：:The Rho family of GTPases control diverse biological processes, including cell morphology and mitogenesis. We have identified WASP, the protein that is defective in Wiskott-Aldrich syndrome (WAS), as a novel effector for CDC42Hs, but not for the other Rho family members, Rac and Rho. This interaction is dependent on t...

journal_title：Cell

authors： Symons M,Derry JM,Karlak B,Jiang S,Lemahieu V,Mccormick F,Francke U,Abo A

更新日期：1996-03-08 00:00:00

abstract：:TOR complex 1 (TORC1) is a potent anabolic regulator of cellular growth and metabolism. When cells have sufficient amino acids, TORC1 is active due to its lysosomal localization mediated via the Rag GTPases. Upon amino acid removal, the Rag GTPases release TORC1, causing it to become cytoplasmic and inactive. We show ...

journal_title：Cell

authors： Demetriades C,Doumpas N,Teleman AA

更新日期：2014-02-13 00:00:00

abstract：:Invasive lobular carcinoma (ILC) is the second most prevalent histologic subtype of invasive breast cancer. Here, we comprehensively profiled 817 breast tumors, including 127 ILC, 490 ductal (IDC), and 88 mixed IDC/ILC. Besides E-cadherin loss, the best known ILC genetic hallmark, we identified mutations targeting PTE...

journal_title：Cell

authors： Ciriello G,Gatza ML,Beck AH,Wilkerson MD,Rhie SK,Pastore A,Zhang H,McLellan M,Yau C,Kandoth C,Bowlby R,Shen H,Hayat S,Fieldhouse R,Lester SC,Tse GM,Factor RE,Collins LC,Allison KH,Chen YY,Jensen K,Johnson NB,O

更新日期：2015-10-08 00:00:00