Proliferation, senescence, and neoplastic progression of beta cells in hyperplasic pancreatic islets.

Abstract:

:Three different cases of pancreatic beta cell hyperplasia in mice are accompanied by an increase in a subclass of cells expressing tyrosine hydroxylase (TH), a neuronal enzyme. In the nontumorigenic cases of islet growth during normal pregnancy and in the obese mutant mouse, the TH-insulin cells do not divide, in contrast to the "insulin-only" cells. In later stages the number of proliferating insulin-only cells decreases concomitant with an increase in the number of nondividing TH-insulin cells, suggesting that the TH-insulin cells are on a pathway to senescence. In the presence of an oncoprotein the TH-insulin cells are able to proliferate. The proliferation of this cell type may represent an escape from the senescence pathway and progression to immortal tumor cells.

journal_name

Cell

journal_title

Cell

authors

Teitelman G,Alpert S,Hanahan D

doi

10.1016/0092-8674(88)90534-x

subject

Has Abstract

pub_date

1988-01-15 00:00:00

pages

97-105

issue

1

eissn

0092-8674

issn

1097-4172

pii

0092-8674(88)90534-X

journal_volume

52

pub_type

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