Abstract:
:The histone tails on the nucleosome surface are subject to enzyme-catalyzed modifications that may, singly or in combination, form a code specifying patterns of gene expression. Recent papers provide insights into how a combinatorial code might be set and read. They show how modification of one residue can influence that of another, even when they are located on different histones, and how modifications at specific genomic locations might be perpetuated on newly assembled chromatin.
journal_name
Celljournal_title
Cellauthors
Turner BMdoi
10.1016/s0092-8674(02)01080-2subject
Has Abstractpub_date
2002-11-01 00:00:00pages
285-91issue
3eissn
0092-8674issn
1097-4172pii
S0092867402010802journal_volume
111pub_type
评论,杂志文章,评审相关文献
CELL文献大全abstract::Dynamic changes in histone and transcription factor acetylation modulate gene expression. A study in Science (Wellen et al., 2009) reports that changes in glucose metabolism alter the availability of acetyl-CoA, the essential cofactor for protein acetylation. These findings reveal a direct connection between central m...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2009.06.025
更新日期:2009-07-10 00:00:00
abstract::The formation of morphogen gradients is essential for tissue patterning. Morphogens are released from producing cells and spread through adjacent tissue; paradoxically, however, many morphogens, including Wingless, associate tightly with the cell membrane. Here, we describe a novel cell biological mechanism that dispe...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(01)00484-6
更新日期:2001-09-07 00:00:00
abstract::Affordable genome sequencing technologies promise to revolutionize the field of human genetics by enabling comprehensive studies that interrogate all classes of genome variation, genome-wide, across the entire allele frequency spectrum. Ongoing projects worldwide are sequencing many thousands-and soon millions-of huma...
journal_title:Cell
pub_type: 杂志文章,评审
doi:10.1016/j.cell.2019.02.032
更新日期:2019-03-21 00:00:00
abstract::Accurately predicting an outcome requires that animals learn supporting and conflicting evidence from sequential experience. In mammals and invertebrates, learned fear responses can be suppressed by experiencing predictive cues without punishment, a process called memory extinction. Here, we show that extinction of av...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2018.08.021
更新日期:2018-10-18 00:00:00
abstract::AMPA receptors mediate fast excitatory neurotransmission in the mammalian brain and transduce the binding of presynaptically released glutamate to the opening of a transmembrane cation channel. Within the postsynaptic density, however, AMPA receptors coassemble with transmembrane AMPA receptor regulatory proteins (TAR...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2017.07.045
更新日期:2017-09-07 00:00:00
abstract::The lateral hypothalamic (LH) projection to the ventral tegmental area (VTA) has been linked to reward processing, but the computations within the LH-VTA loop that give rise to specific aspects of behavior have been difficult to isolate. We show that LH-VTA neurons encode the learned action of seeking a reward, indepe...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2015.01.003
更新日期:2015-01-29 00:00:00
abstract::Meiotic recombination occurs preferentially between homologous nonsister chromatids rather than between sisters, opposite to the bias of mitotic recombinational repair. We have examined formation of joint molecule recombination intermediates (JMs) between homologs and between sisters in yeast strains lacking the meiot...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(00)80378-5
更新日期:1997-09-19 00:00:00
abstract::Characteristic of chronic myelogenous leukemia (CML) is the presence of the chimeric p210(bcr-abl) protein possessing elevated protein tyrosine kinase activity relative to normal c-abl tyrosine kinase. Hematopoietic progenitors isolated from CML patients in the chronic phase contain a constitutively tyrosine-phosphory...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(00)81840-1
更新日期:1997-01-24 00:00:00
abstract::Eukaryotic cells have developed mechanisms for regulating the nuclear transport of macromolecules that control various cellular events including movement through defined stages of the cell cycle. In yeast cells, where the nuclear envelope remains intact throughout the cell cycle, these transport regulatory mechanisms ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(03)00986-3
更新日期:2003-12-26 00:00:00
abstract::The loss of expression of particular microRNAs can contribute to tumorigenesis. Kota et al. (2009) now explore in a mouse model a promising new approach for the treatment of liver cancer-re-establishing the expression of an miRNA using a viral vector. ...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2009.05.038
更新日期:2009-06-12 00:00:00
abstract::Organisms maintain the correct balance of intracellular metals primarily through metal-sensing proteins that control transport and storage of the target ion(s). Here, we reveal the basis of metal sensing and genetic control by a metalloregulatory RNA. Our data demonstrate that a previously uncharacterized orphan ribos...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2007.06.051
更新日期:2007-09-07 00:00:00
abstract::The transport kinetics of the influenza virus hemagglutinin from its site of synthesis to the apical plasma membrane of Madin-Darby canine kidney cells, a polarized epithelial cell line, were studied by a sensitive tryptic assay. Hemagglutinin acquired terminal sugars, as judged by sensitivity to endo-beta-N-acetylglu...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(83)90154-x
更新日期:1983-08-01 00:00:00
abstract::While mutations affecting protein-coding regions have been examined across many cancers, structural variants at the genome-wide level are still poorly defined. Through integrative deep whole-genome and -transcriptome analysis of 101 castration-resistant prostate cancer metastases (109X tumor/38X normal coverage), we i...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2018.06.039
更新日期:2018-07-26 00:00:00
abstract::The pathway of RNA polymerase entry at the lac promoter was studied by investigating the relationship between the promoter and a weak, overlapping polymerase interaction site (P2). If polymerase is made to enter the DNA by binding in vitro at this P2 site, cyclic AMP receptor protein (CRP) actively removes polymerase ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(85)90250-8
更新日期:1985-12-01 00:00:00
abstract::In embryonal carcinoma (EC) cells retinoic acid (RA) strongly induces transcription from the RA receptor beta 2 (RAR beta 2) promoter through an RA response element (RARE) located in close proximity to the TATA box. Here we demonstrate that recombinant human TATA box-binding protein, hTFIID, and RAR functionally coope...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(92)90443-g
更新日期:1992-05-01 00:00:00
abstract::The surface glycoproteins T4 and T8 define different functional subsets of T lymphocytes and may act as recognition molecules mediating appropriate interactions between the T cell and its target. Previously we employed gene transfer and subtractive hybridization to isolate a T8 cDNA; now we have isolated and sequenced...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(85)80105-7
更新日期:1985-08-01 00:00:00
abstract::Two key events in Wnt signal transduction, receptor endocytosis and inactivation of Glycogen Synthase Kinase 3 (GSK3), remain incompletely understood. Taelman et al. (2010) discover that Wnt signaling inactivates GSK3 by sequestering the enzyme in multivesicular bodies, thus linking these two events and providing a ne...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2010.12.003
更新日期:2010-12-23 00:00:00
abstract::Neurons make networks of intercellular connections. Many other cells also send out long cellular extensions and "touch" other cells far away. The extensions are intriguing, but what do they do? Possible rationales for this cell behavior include: (1) forming precise binary connections with the possibility of forming mo...
journal_title:Cell
pub_type: 杂志文章,评审
doi:10.1016/s0092-8674(03)00156-9
更新日期:2003-03-07 00:00:00
abstract::The dorsal raphe nucleus (DRN) is an important brain area for body-weight regulation. In this issue of Cell, Nectow et al. uncover cell-type-specific neural circuitry and pharmacology for appetite control within the DRN. ...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2017.07.017
更新日期:2017-07-27 00:00:00
abstract::Of the several families of adhesion receptors involved in leukocyte-endothelial cell interactions, only the selectins have been shown to initiate leukocyte interaction under physiologic shear; indeed, beta 2 (CD18) intergrins responsible for neutrophil arrest are unable to engage without prior selectin-mediated rollin...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(95)90491-3
更新日期:1995-02-10 00:00:00
abstract::For many scientific awards, such as Nobels and Laskers, the maximum number of recipients is three. This Rule of Three forces selection committees to make difficult decisions that increase the likelihood of singling out those individuals who open a new field and continue to lead it. The Rule of Three is reminiscent of ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2016.08.040
更新日期:2016-09-22 00:00:00
abstract::Cyclin B is degraded at the onset of anaphase by a ubiquitin-dependent proteolytic system. We have fractionated mitotic Xenopus egg extracts to identify components required for this process. We find that UBC4 and at least one other ubiquitin-conjugating enzyme can support cyclin B ubiquitination. The mitotic specifici...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(95)90338-0
更新日期:1995-04-21 00:00:00
abstract::In this issue of Cell, a study by Valerie Mizrahi and her colleagues suggests that a putative error-prone DNA polymerase encoded by the dnaE2 gene of Mycobacterium tuberculosis may bypass certain types of DNA base damage, generating mutations. This may be an important mechanism for generating drug-resistant strains of...
journal_title:Cell
pub_type: 评论,杂志文章,评审
doi:10.1016/s0092-8674(03)00275-7
更新日期:2003-04-18 00:00:00
abstract::Long pyrimidine tracts, purified from Drosophila melanogaster DNA after treatment with formic acid-diphenylamine, were used as template for E. coli RNA polymerase to produce a polynucleotide containing only purines. This polypurine RNA hybridized specifically to D. melanogaster DNA with high efficiency at low Cot valu...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(75)90026-4
更新日期:1975-06-01 00:00:00
abstract::Genetic screening identifies the atypical tetraspanin TM4SF1 as a strong mediator of metastatic reactivation of breast cancer. Intriguingly, TM4SF1 couples the collagen receptor tyrosine kinase DDR1 to the cortical adaptor syntenin 2 and, hence, to PKCα. The latter kinase phosphorylates and activates JAK2, leading to ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2016.06.009
更新日期:2016-06-30 00:00:00
abstract::We present genetic evidence that integrins regulate epithelial-mesenchymal interactions during organogenesis. Mice with a mutation in the alpha8 gene do not express the integrin alpha8 beta1 and exhibit profound deficits in kidney morphogenesis. In wild-type animals, inductive interactions between the ureteric epithel...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(00)81903-0
更新日期:1997-03-07 00:00:00
abstract::Glial cells are essential components of the nervous system. In this issue, Singhvi et al. uncover cellular and molecular mechanisms through which C. elegans glia shape sensory neuron terminals and thus control animal thermosensing behaviors. ...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2016.04.052
更新日期:2016-05-05 00:00:00
abstract::During development, distinct classes of neurons are specified in precise locations along the dorso-ventral and anterior-posterior axes of the neural tube. We provide evidence that intersections of Shh, which is expressed along the ventral neural tube, and FGF8, which is locally produced at the mid/hindbrain boundary a...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(00)81437-3
更新日期:1998-05-29 00:00:00
abstract::We have cloned a Dictyostelium phosphotyrosine phosphatase (PTP1) with a catalytic domain showing approximately 38%-50% amino acid identity to those of other PTPs. PTP1 contains an approximately 99 amino acid insert and bacterially produced PTP1 possesses PTP activity. PTP1 is expressed at a very low level in vegetati...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(92)90597-6
更新日期:1992-11-13 00:00:00
abstract::Kinetochores direct attachment of chromosomes to microtubules of the mitotic spindle during cell division. Three recent studies in Cell, including one in this issue, reveal important new roles for two kinetochore protein complexes-Ndc80 and INCENP-Survivin-in establishing the correct attachment of chromosomes to spind...
journal_title:Cell
pub_type: 杂志文章,评审
doi:10.1016/j.cell.2006.11.032
更新日期:2006-12-15 00:00:00