Abstract:
:We present genetic evidence that integrins regulate epithelial-mesenchymal interactions during organogenesis. Mice with a mutation in the alpha8 gene do not express the integrin alpha8 beta1 and exhibit profound deficits in kidney morphogenesis. In wild-type animals, inductive interactions between the ureteric epithelium and metanephric mesenchyme are essential for kidney morphogenesis. In alpha8 mutant homozygotes, growth and branching of the ureteric bud and recruitment of mesenchymal cells into epithelial structures are defective. Consistent with these phenotypes, alpha8 expression is induced in mesenchymal cells upon contact with the ureter. Since none of its previously identified ligands appears likely to mediate the essential functions of alpha8 beta1 in kidney morphogenesis, we have used an alpha8 beta1-alkaline phosphatase chimera to localize novel ligand(s) in the growing ureter. The distribution of these ligand(s) makes them strong candidates for regulators of kidney morphogenesis.
journal_name
Celljournal_title
Cellauthors
Müller U,Wang D,Denda S,Meneses JJ,Pedersen RA,Reichardt LFdoi
10.1016/s0092-8674(00)81903-0subject
Has Abstractpub_date
1997-03-07 00:00:00pages
603-13issue
5eissn
0092-8674issn
1097-4172pii
S0092-8674(00)81903-0journal_volume
88pub_type
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