Abstract：
:One of the important events in synapse formation is the accumulation of neurotransmitter receptors beneath the presynaptic nerve terminal. Agrin is a component of the synaptic basal lamina that induces the clustering of acetylcholine receptors when bath-applied to muscle fibers in culture. When a cDNA encoding a putative agrin protein is transfected into cells, the molecule is secreted and concentrated on the extracellular surface. Coculture of transfected cells with muscle fibers induces the formation of receptor patches at contact sites. These results demonstrate that expression of a single gene encoding agrin confers receptor clustering that is restricted to specific sites of cell-muscle contact.
journal_name
Celljournal_title
Cellauthors
Campanelli JT,Hoch W,Rupp F,Kreiner T,Scheller RHdoi
10.1016/0092-8674(91)90364-5subject
Has Abstractpub_date
1991-11-29 00:00:00pages
909-16issue
5eissn
0092-8674issn
1097-4172pii
0092-8674(91)90364-5journal_volume
67pub_type
杂志文章相关文献
CELL文献大全abstract：:Microtubule-dependent motor, murine KIF3B, was disrupted by gene targeting. The null mutants did not survive beyond midgestation, exhibiting growth retardation, pericardial sac ballooning, and neural tube disorganization. Prominently, the left-right asymmetry was randomized in the heart loop and the direction of embry...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)81705-5
更新日期：1998-12-11 00:00:00
abstract：:A plasmid containing the major late promoter was assembled into nucleosomes in a Xenopus oocyte extract, isolated by gel filtration, and found to be refractory to transcription initiation in vitro. However, exposure of the promoter to HeLa nuclear extract or to a mixture of isolated transcription factors prior to nucl...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(87)90130-9
更新日期：1987-11-20 00:00:00
abstract：:Adult neovascularization relies on the recruitment of circulating cells, but their angiogenic roles and recruitment mechanisms are unclear. We show that the endothelial growth factor VEGF is sufficient for organ homing of circulating mononuclear myeloid cells and is required for their perivascular positioning and rete...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2005.10.036
更新日期：2006-01-13 00:00:00
abstract：:Cytoplasmic dynein is a motor protein that exerts force on microtubules. To generate force for the movement of large organelles, dynein needs to be anchored, with the anchoring sites being typically located at the cell cortex. However, the mechanism by which dyneins target sites where they can generate large collectiv...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2013.05.020
更新日期：2013-06-20 00:00:00
abstract：:Cellular ras activity has been neutralized in 3T3 cells by microinjection of a specific anti-ras monoclonal antibody. The injected antibody efficiently inhibited proliferation in cells treated with a phorbol ester and a calcium ionophore, or with prostaglandin F2 alpha. These treatments were designed to imitate the ac...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(88)90531-4
更新日期：1988-01-15 00:00:00
abstract：:Five single base pair mutations that increase expression of the tnpA (transposase) gene of the Tn3 transposon approximately 30-fold, but which still allow the gene to be regulated, have been isolated by using a generally applicable procedure that involves distally linked lac gene fusions. The mutations, which are all ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(82)90352-x
更新日期：1982-02-01 00:00:00
abstract：:In dividing cells, nuclear pore complexes (NPCs) disassemble during mitosis and reassemble into the newly forming nuclei. However, the fate of nuclear pores in postmitotic cells is unknown. Here, we show that NPCs, unlike other nuclear structures, do not turn over in differentiated cells. While a subset of NPC compone...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2008.11.037
更新日期：2009-01-23 00:00:00
abstract：:Bacteria have evolved many different means of generating movement. In this issue of Cell, Shaevitz et al. (2005) describe the swimming movement of a helical bacterium called Spiroplasma. They discover that Spiroplasma propels itself by generating two temporally distinct kinks that travel the length of the bacterium. T...
journal_title：Cell
pub_type： 评论,杂志文章,评审
doi：10.1016/j.cell.2005.09.003
更新日期：2005-09-23 00:00:00
abstract：:The triskelion shape of the clathrin molecule enables it to form the polyhedral protein network that covers clathrin-coated pits and vesicles. Domains within the clathrin heavy chain that are responsible for maintaining triskelion shape and function were identified and localized. Sequences that mediate trimerization a...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(92)90033-9
更新日期：1992-03-06 00:00:00
abstract：:Metastasis is the leading cause of cancer-associated death but has been difficult to study because it involves a series of rare, stochastic events. To capture these events, we developed a sensitive method to tag and track pancreatic epithelial cells in a mouse model of pancreatic cancer. Tagged cells invaded and enter...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2011.11.025
更新日期：2012-01-20 00:00:00
abstract：:Infectious disease is both a major force of selection in nature and a prime cause of yield loss in agriculture. In plants, disease resistance is often conferred by nucleotide-binding leucine-rich repeat (NLR) proteins, intracellular immune receptors that recognize pathogen proteins and their effects on the host. Consi...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2019.07.038
更新日期：2019-08-22 00:00:00
abstract：:The replication initiator protein of the plasmid R6K binds to seven contiguous 22 bp direct repeats that form an indispensable part of the three replication origins alpha, beta, and gamma. Binding of the initiator to the direct repeats induced a marked bending of the region of gamma replication origin. Binding of the ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(85)90023-6
更新日期：1985-11-01 00:00:00
abstract：:In RNA-mediated interference (RNAi), double-stranded RNAs (dsRNAs) target complementary mRNAs for degradation. New work demonstrates that essential chromosomal functions are mediated through RNAi protein components and short RNAs, which alter chromosome function at specific DNA loci via histone modification. ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(02)01039-5
更新日期：2002-10-18 00:00:00
abstract：:Chronic Pseudomonas aeruginosa infections evade antibiotic therapy and are associated with mortality in cystic fibrosis (CF) patients. We find that in vitro resistance evolution of P. aeruginosa toward clinically relevant antibiotics leads to phenotypic convergence toward distinct states. These states are associated w...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2017.12.012
更新日期：2018-01-11 00:00:00
abstract：:The yeast SIR2 gene is involved in regulating nucleosome phasing and transcription in the mating type system. We have found that SIR2 also plays another important role in the cell. Specifically, in wild-type SIR2 strains recombination between the tandemly repeated ribosomal RNA genes is depressed. In sir2 mutants, bot...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(89)90681-8
更新日期：1989-03-10 00:00:00
abstract：:The RNA helicase eIF4A plays a key role in unwinding of mRNA and scanning during translation initiation. Free eIF4A is a poor helicase and requires the accessory proteins eIF4G and eIF4H. However, the structure of the helicase complex and the mechanisms of stimulation of eIF4A activity have remained elusive. Here we r...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2009.01.014
更新日期：2009-02-06 00:00:00
abstract：:p11, through unknown mechanisms, is required for behavioral and cellular responses to selective serotonin reuptake inhibitors (SSRIs). We show that SMARCA3, a chromatin-remodeling factor, is a target for the p11/annexin A2 heterotetrameric complex. Determination of the crystal structure indicates that SMARCA3 peptide ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2013.01.014
更新日期：2013-02-14 00:00:00
abstract：:Neurons make networks of intercellular connections. Many other cells also send out long cellular extensions and "touch" other cells far away. The extensions are intriguing, but what do they do? Possible rationales for this cell behavior include: (1) forming precise binary connections with the possibility of forming mo...
journal_title：Cell
pub_type： 杂志文章,评审
doi：10.1016/s0092-8674(03)00156-9
更新日期：2003-03-07 00:00:00
abstract：:Long-term severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) shedding was observed from the upper respiratory tract of a female immunocompromised individual with chronic lymphocytic leukemia and acquired hypogammaglobulinemia. Shedding of infectious SARS-CoV-2 was observed up to 70 days, and of genomic and s...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2020.10.049
更新日期：2020-12-23 00:00:00
abstract：:A 1.1 kb intron containing an open reading frame (ORF) in one allele (omega+) of the yeast mitochondrial 21S rRNA gene is nearly quantitatively inserted in crosses into a 21S rRNA allele lacking that intron (omega-). We have determined that this nonreciprocal exchange initiates soon after cells fuse to form zygotes an...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(85)90348-4
更新日期：1985-04-01 00:00:00
abstract：:In cells of the B-lymphocyte lineage, 8.4 kb transcripts are constitutively produced from unrearranged kappa constant region (kappa 0) loci. To help elucidate the molecular basis of this phenomenon, we have determined the nucleotide sequence surrounding the site of transcriptional initiation. The kappa 0 transcripts a...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(81)90401-3
更新日期：1981-12-01 00:00:00
abstract：:Acquisition of the ability to produce and respond to a growth factor may result in increased cellular proliferation and could lead to malignant transformation. The fact that a large variety of tumor cells secrete transforming growth factor-alpha (TGF-alpha) suggests involvement of TGF-alpha in cellular transformation ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(86)90747-6
更新日期：1986-07-18 00:00:00
abstract：:In the developing nervous system, neural progenitors exit the cell cycle and differentiate on a precise schedule, yet the mechanisms driving this process remain poorly defined. Yan et al. (2009) now identify a thiol-redox reaction mediated by the membrane protein GDE2 and the peroxiredoxin protein Prdx1 that promotes ...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2009.09.001
更新日期：2009-09-18 00:00:00
abstract：:DNA demethylating agents are approved for some blood malignancies and are under active investigation in solid tumors, but how these drugs work has remained unclear. In this issue of Cell, two groups show that these agents activate a toxic cellular antiviral program through transcriptional activation of endogenous retr...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2015.08.005
更新日期：2015-08-27 00:00:00
abstract：:The small molecular weight RNAs of the HeLa cell have been located in specific subcellular fractions. SnA is located in the nucleolus and is partially bonded to nucleolar 28S RNA. SnD, the most abundant of the small nuclear RNAs, is partially released from the nucleus when the nuclear preparation is briefly warmed. Sn...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(76)90181-1
更新日期：1976-05-01 00:00:00
abstract：:In familial searching in forensic genetics, a query DNA profile is tested against a database to determine whether it represents a relative of a database entrant. We examine the potential for using linkage disequilibrium to identify pairs of profiles as belonging to relatives when the query and database rely on nonover...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2018.09.008
更新日期：2018-10-18 00:00:00
abstract：:Multipotent cardiac progenitor cells are found in the fetal and adult heart of many mammalian species including humans and form as intermediates during the differentiation of embryonic stem cells. Despite similar biological properties, the molecular identities of these different cardiac progenitor cell populations app...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2008.02.002
更新日期：2008-02-22 00:00:00
abstract：:Small nucleolar RNAs represent an abundant, evolutionarily ancient group of noncoding RNAs which possess impressively diverse functions ranging from 2'-O-methylation and pseudouridylation of various classes of RNAs, through nucleolytic processing of rRNAs to the synthesis of telomeric DNA. ...
journal_title：Cell
pub_type： 杂志文章,评审
doi：10.1016/s0092-8674(02)00718-3
更新日期：2002-04-19 00:00:00
abstract：:We have examined the long-range distribution of double-stranded DNA cleavage sites for Drosophila melanogaster topoisomerase II. These studies reveal a novel partitioning of preferred topoisomerase II cleavage sites. In the eukaryotic DNAs examined, major cleavage sites were typically found in nontranscribed spacer se...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(85)90353-8
更新日期：1985-04-01 00:00:00
abstract：:The Wee1 kinase phosphorylates and inhibits cyclin-dependent kinase 1 (Cdk1), thereby delaying entry into mitosis until appropriate conditions have been met. An understanding of the mechanisms that regulate Wee1 should provide new insight into how cells make the decision to enter mitosis. We report here that Swe1, the...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2005.05.029
更新日期：2005-08-12 00:00:00
