Case Study: Prolonged Infectious SARS-CoV-2 Shedding from an Asymptomatic Immunocompromised Individual with Cancer.

abstract：:SecA, the peripheral subunit of E. coli preprotein translocase, alternates between a membrane inserted and a deinserted state as part of the catalytic cycle of preprotein translocation. When SecA is complexed with SecY/E and preprotein, ATP drives a profound conformational change, leading to membrane insertion of a 30...

journal_title：Cell

authors： Economou A,Wickner W

更新日期：1994-09-09 00:00:00

abstract：:Goosecoid (gsc), a homeobox gene expressed specifically in the dorsal blastopore lip of the Xenopus gastrula, is considered to play an important role in Spemann's organizer phenomenon. Lineage tracing and time-lapse microscopy were used to follow the fate of embryonic cells microinjected with gsc mRNA. Microinjected g...

journal_title：Cell

authors： Niehrs C,Keller R,Cho KW,De Robertis EM

更新日期：1993-02-26 00:00:00

abstract：:Thymocyte commitment to the CD4 helper versus CD8 cytotoxic lineage has not been satisfactorily established. Two models have been elaborated: one based on instruction, the other on selection. Most previous results support the instructive model, but our comparison of thymocyte differentiation in MHC class II-, class I-...

journal_title：Cell

authors： Chan SH,Cosgrove D,Waltzinger C,Benoist C,Mathis D

更新日期：1993-04-23 00:00:00

abstract：:Dot1 is an evolutionarily conserved histone methyltransferase that methylates lysine-79 of histone H3 in the core domain. Unlike other histone methyltransferases, Dot1 does not contain a SET domain, and it specifically methylates nucleosomal histone H3. We have solved a 2.5 A resolution structure of the catalytic doma...

journal_title：Cell

authors： Min J,Feng Q,Li Z,Zhang Y,Xu RM

更新日期：2003-03-07 00:00:00

abstract：:Thyroid hormone (T3) and retinoic acid (RA) receptors mediate ligand-dependent inhibition of epidermal growth factor (EGF) receptor and c-erbB2/neu promoter activities. Ligand-activated T3 and RA receptors act via a 36 bp 5' fragment of the EGF receptor gene in vivo and, in the presence of nuclear extract, bind with h...

journal_title：Cell

authors： Hudson LG,Santon JB,Glass CK,Gill GN

更新日期：1990-09-21 00:00:00

abstract：:Synaptotagmin is one of the major integral membrane proteins of synaptic vesicles. It has been postulated to dock vesicles to their release sites, to act as the Ca2+ sensor for the release process, and to be a fusion protein during exocytosis. To clarify the function of this protein, we have undertaken a genetic analy...

journal_title：Cell

authors： DiAntonio A,Parfitt KD,Schwarz TL

更新日期：1993-07-02 00:00:00

abstract：:Vertebrate Hoxd genes are sequentially activated during the morphogenesis and pattern formation of the limb. Using the approach of gene disruption via homologous recombination in embryonic stem cells, we have assessed the function of the last gene of the complex, Hoxd-13. Mutant mice displayed skeletal alterations alo...

journal_title：Cell

authors： Dollé P,Dierich A,LeMeur M,Schimmang T,Schuhbaur B,Chambon P,Duboule D

更新日期：1993-11-05 00:00:00

abstract：:Two decades of research identified more than a dozen clock genes and defined a biochemical feedback mechanism of circadian oscillator function. To identify additional clock genes and modifiers, we conducted a genome-wide small interfering RNA screen in a human cellular clock model. Knockdown of nearly 1000 genes reduc...

journal_title：Cell

authors： Zhang EE,Liu AC,Hirota T,Miraglia LJ,Welch G,Pongsawakul PY,Liu X,Atwood A,Huss JW 3rd,Janes J,Su AI,Hogenesch JB,Kay SA

更新日期：2009-10-02 00:00:00

abstract：:The enteric bacteria Salmonella typhimurium has the ability to invade (enter) nonphagocytic cells. The internalization process occurs as a result of an intimate interaction between the bacteria and the host cell, in which S. typhimurium triggers a cascade of host cell-signaling events leading to the formation of host ...

journal_title：Cell

authors： Ginocchio CC,Olmsted SB,Wells CL,Galán JE

更新日期：1994-02-25 00:00:00

abstract：:Newly synthesized proteins are believed to move from the endoplasmic reticulum (ER) to the Golgi by bulk flow, and sorting is assumed to occur exclusively in the trans-Golgi network (TGN). Using quantitative immunoelectron microscopy, we demonstrate that vesicular stomatitis virus glycoprotein (VSV-G) is sorted from r...

journal_title：Cell

authors： Balch WE,McCaffery JM,Plutner H,Farquhar MG

更新日期：1994-03-11 00:00:00

abstract：:NF-kappaB, a key regulator of the cellular inflammatory and immune response, is activated by the HTLV-I transforming and transactivating protein Tax. We show that Tax binds to the amino terminus of the protein kinase MEKK1, a component of an IkappaB kinase complex, and stimulates MEKK1 kinase activity. Tax expression ...

journal_title：Cell

authors： Yin MJ,Christerson LB,Yamamoto Y,Kwak YT,Xu S,Mercurio F,Barbosa M,Cobb MH,Gaynor RB

更新日期：1998-05-29 00:00:00

abstract：:Membrane scission is essential for intracellular trafficking. While BAR domain proteins such as endophilin have been reported in dynamin-independent scission of tubular membrane necks, the cutting mechanism has yet to be deciphered. Here, we combine a theoretical model, in vitro, and in vivo experiments revealing how ...

journal_title：Cell

authors： Simunovic M,Manneville JB,Renard HF,Evergren E,Raghunathan K,Bhatia D,Kenworthy AK,Voth GA,Prost J,McMahon HT,Johannes L,Bassereau P,Callan-Jones A

更新日期：2017-06-29 00:00:00

abstract：:The association of histone modification changes with autism spectrum disorder (ASD) has not been systematically examined. We conducted a histone acetylome-wide association study (HAWAS) by performing H3K27ac chromatin immunoprecipitation sequencing (ChIP-seq) on 257 postmortem samples from ASD and matched control brai...

journal_title：Cell

authors： Sun W,Poschmann J,Cruz-Herrera Del Rosario R,Parikshak NN,Hajan HS,Kumar V,Ramasamy R,Belgard TG,Elanggovan B,Wong CCY,Mill J,Geschwind DH,Prabhakar S

更新日期：2016-11-17 00:00:00

abstract：:Plant seedling development is capable of following 1 of 2 distinct morphogenic pathways: skotomorphogenesis in darkness and photomorphogenesis in light. Dark-grown Arabidopsis seedlings with recessive mutations at the constitutively photomorphogenic (COP1) locus indicate that the wild-type COP1 protein represses photo...

journal_title：Cell

authors： Deng XW,Matsui M,Wei N,Wagner D,Chu AM,Feldmann KA,Quail PH

更新日期：1992-11-27 00:00:00

abstract：:Pejvakin (PJVK), a protein originally identified in Persian families with sensorineural hearing loss, regulates peroxisomal dynamics and the antioxidant defense triggered by noise exposure in hair cells and auditory neurons of the inner ear. These findings bring peroxisomes to the forefront of noise-induced hearing lo...

journal_title：Cell

authors： Mardones P,Hetz C

更新日期：2015-11-05 00:00:00

abstract：:Given the heterogeneity of senescent cells, our knowledge of both the drivers and consequences of cellular senescence in tissues and organs remains limited, as is our understanding of how this process could be harnessed for human health. Here we identified five broad areas that would help propel the field forward. ...

journal_title：Cell

authors： Roy AL,Sierra F,Howcroft K,Singer DS,Sharpless N,Hodes RJ,Wilder EL,Anderson JM

更新日期：2020-11-25 00:00:00

abstract：:Prions have been responsible for an entire century of tragic episodes. Fifty years ago, kuru decimated the population of Papua New Guinea. Then, iatrogenic transmission of prions caused more than 250 cases of Creutzfeldt-Jakob disease. More recently, transmission of bovine spongiform encephalopathy to humans caused a ...

journal_title：Cell

authors： Aguzzi A,Polymenidou M

更新日期：2004-01-23 00:00:00

abstract：:We constructed rabbit beta-globin genes with deletions in the large intron, extending from the midpoint toward the 5' or 3' splice sites. Analysis of transcripts in transformed HeLa cells showed that six 5' proximal intron nucleotides allowed normal splicing. Correct splicing at the 3' splice site required 12 or more ...

journal_title：Cell

authors： Wieringa B,Hofer E,Weissmann C

更新日期：1984-07-01 00:00:00

abstract：:The sequence of about one third of the polyoma virus genome is presented. This sequence covers the origin of replication of two large plaque strains (A2 and A3) of polyoma virus. The two strains differ by 11 bp in the origin region. A model for replication is suggested. The sequence probably also covers the entire cod...

journal_title：Cell

authors： Soeda E,Arrand JR,Smolar N,Griffin BE

更新日期：1979-06-01 00:00:00

abstract：:The lateral hypothalamic (LH) projection to the ventral tegmental area (VTA) has been linked to reward processing, but the computations within the LH-VTA loop that give rise to specific aspects of behavior have been difficult to isolate. We show that LH-VTA neurons encode the learned action of seeking a reward, indepe...

journal_title：Cell

authors： Nieh EH,Matthews GA,Allsop SA,Presbrey KN,Leppla CA,Wichmann R,Neve R,Wildes CP,Tye KM

更新日期：2015-01-29 00:00:00

abstract：:Cholera toxin inhibition of progesterone-induced meiosis of Xenopus laevis oocytes in vitro has been correlated with increased cAMP levels. Inhibition of germinal vesicle breakdown (Gvbd) and cAMP increase occurred after a lag period of 2 hr, when cholera toxin was injected, or 4--5 hr, when applied externally. The ab...

journal_title：Cell

authors： Schorderet-Slatkine S,Schorderet M,Boquet P,Godeau F,Baulieu EE

更新日期：1978-12-01 00:00:00

abstract：:Alterations of symbiosis between microbiota and intestinal epithelial cells (IEC) are associated with intestinal and systemic pathologies. Interactions between bacterial products (MAMPs) and Toll-like receptors (TLRs) are known to be mandatory for IEC homeostasis, but how TLRs may time homeostatic functions with circa...

journal_title：Cell

authors： Mukherji A,Kobiita A,Ye T,Chambon P

更新日期：2013-05-09 00:00:00

abstract：:We have analyzed the viral DNA sequences persisting in HE C19, a clonal line of hamster embryo cells transformed in vitro by human adenovirus 12 (Ad 12), a member of highly oncogenic group A. Saturation-hybridization of in vitro labeled Ad 12 DNA (2-4 x 10(8) cpm/mug) with HE C19 DNA showed that 93-100% of viral DNA s...

journal_title：Cell

authors： Green MR,Chinnadurai G,Mackey JK,Green M

更新日期：1976-03-01 00:00:00

abstract：:PTEN is a frequently mutated tumor suppressor gene that opposes the PI3K/AKT pathway through dephosphorylation of phosphoinositide-3,4,5-triphosphate. Recently, nuclear compartmentalization of PTEN was found as a key component of its tumor-suppressive activity; however its nuclear function remains poorly defined. Here...

journal_title：Cell

authors： Song MS,Carracedo A,Salmena L,Song SJ,Egia A,Malumbres M,Pandolfi PP

更新日期：2011-01-21 00:00:00

abstract：:Murine intracisternal A particles have a number of properties which are common to known RNA tumor viruses, but horizontal transmission has not been previously demonstrated. The apparent absence of infectivity may be related to the failure of these particles to be released from cisternae of endo-plasmic reticulum. Prev...

journal_title：Cell

authors： Malech HL,Wivel NA

更新日期：1976-11-01 00:00:00

abstract：:Coliphage N4 virion-encapsidated, DNA-dependent RNA polymerase (vRNAP) is inactive on double-stranded N4 DNA; however, denatured promoter-containing templates are accurately transcribed. We report that all determinants of vRNAP promoter recognition exist in the template strand, indicating that this enzyme is a site-sp...

journal_title：Cell

authors： Glucksmann MA,Markiewicz P,Malone C,Rothman-Denes LB

更新日期：1992-08-07 00:00:00

abstract：:Can a heterotrophic organism be evolved to synthesize biomass from CO2 directly? So far, non-native carbon fixation in which biomass precursors are synthesized solely from CO2 has remained an elusive grand challenge. Here, we demonstrate how a combination of rational metabolic rewiring, recombinant expression, and lab...

journal_title：Cell

authors： Antonovsky N,Gleizer S,Noor E,Zohar Y,Herz E,Barenholz U,Zelcbuch L,Amram S,Wides A,Tepper N,Davidi D,Bar-On Y,Bareia T,Wernick DG,Shani I,Malitsky S,Jona G,Bar-Even A,Milo R

更新日期：2016-06-30 00:00:00

abstract：:Organ cultures of liver from untreated male Xenopus respond to 17 beta-estradiol in the culture medium by synthesizing and secreting the yolk protein precursor vitellogenin. Vitellogenin synthesis, as a primary response, is first detectable on the fourth day of culture, and comprises up to 12% of the protein synthesiz...

journal_title：Cell

authors： Green CD,Tata JR

更新日期：1976-01-01 00:00:00

abstract：:We employed gene targeting to study H2AX, a histone variant phosphorylated in chromatin surrounding DNA double-strand breaks. Mice deficient for both H2AX and p53 (H(delta/delta)P(-/-)) rapidly developed immature T and B lymphomas and solid tumors. Moreover, H2AX haploinsufficiency caused genomic instability in normal...

journal_title：Cell

authors： Bassing CH,Suh H,Ferguson DO,Chua KF,Manis J,Eckersdorff M,Gleason M,Bronson R,Lee C,Alt FW

更新日期：2003-08-08 00:00:00

abstract：:Metastasis is the leading cause of cancer-associated death but has been difficult to study because it involves a series of rare, stochastic events. To capture these events, we developed a sensitive method to tag and track pancreatic epithelial cells in a mouse model of pancreatic cancer. Tagged cells invaded and enter...

journal_title：Cell

authors： Rhim AD,Mirek ET,Aiello NM,Maitra A,Bailey JM,McAllister F,Reichert M,Beatty GL,Rustgi AK,Vonderheide RH,Leach SD,Stanger BZ

更新日期：2012-01-20 00:00:00