Abstract：
:The modularity of protein architecture and the diversity of protein domains hint at a vast combinatorial richness. But evolution appears to have been relatively conservative about selecting new combinations. When a particular grouping of domains within a polypeptide chain can perform a concerted function, that combination tends to reappear in multiple genomic contexts. In other words, once a molecular solution to a functional problem has emerged, it is reused rather than reinvented.
journal_name
Celljournal_title
Cellauthors
Harrison SCdoi
10.1016/s0092-8674(03)00196-xsubject
Has Abstractpub_date
2003-03-21 00:00:00pages
737-40issue
6eissn
0092-8674issn
1097-4172pii
S009286740300196Xjournal_volume
112pub_type
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