Molecular analysis of the histone gene cluster of psammechinus miliaris: II. The arrangement of the five histone-coding and spacer sequences.

abstract：:Subsets of CD4 T cells are defined by the cytokines that they produce; these cytokines determine the effector function of these cells. Cloned CD4 T cells fall into two subsets, producing either interferon-gamma (IFN gamma) or interleukin-4 (IL-4) in combination with other cytokines, and are called Th1 and Th2 cells, r...

journal_title：Cell

authors： Kamogawa Y,Minasi LA,Carding SR,Bottomly K,Flavell RA

更新日期：1993-12-03 00:00:00

abstract：:Heat shock and other proteotoxic stresses cause accumulation of nonnative proteins that trigger activation of heat shock protein (Hsp) genes. A chaperone/Hsp functioning as repressor of heat shock transcription factor (HSF) could make activation of hsp genes dependent on protein unfolding. In a novel in vitro system, ...

journal_title：Cell

authors： Zou J,Guo Y,Guettouche T,Smith DF,Voellmy R

更新日期：1998-08-21 00:00:00

abstract：:Certain mutant alleles at the low density lipoprotein (LDL) receptor locus produce receptors that bind LDL normally, but fail to cluster in coated pits and therefore cannot transport LDL into cells. We prepared genomic DNA libraries from cells of two individuals with this phenotype (internalization-defective familial ...

journal_title：Cell

authors： Lehrman MA,Goldstein JL,Brown MS,Russell DW,Schneider WJ

更新日期：1985-07-01 00:00:00

abstract：:The v-erbB gene of avian erythroblastosis virus (AEV) codes for an integral plasma membrane glycoprotein, gp74erbB. Expression of gp74erbB and its intracellular precursors, gp66erbB and gp68erbB, has been studied in cells transformed by two temperature-sensitive mutants of AEV. After shift to 42 degrees C, the process...

journal_title：Cell

authors： Beug H,Hayman MJ

更新日期：1984-04-01 00:00:00

abstract：:Scientists are stepping up like never before to support science in the public arena. In big and small ways, scientists are adopting creative ideas to promote science. ...

journal_title：Cell

authors： Matheson S

更新日期：2017-04-06 00:00:00

abstract：:The functions of caveolae, the characteristic plasma membrane invaginations, remain debated. Their abundance in cells experiencing mechanical stress led us to investigate their role in membrane-mediated mechanical response. Acute mechanical stress induced by osmotic swelling or by uniaxial stretching results in a rapi...

journal_title：Cell

authors： Sinha B,Köster D,Ruez R,Gonnord P,Bastiani M,Abankwa D,Stan RV,Butler-Browne G,Vedie B,Johannes L,Morone N,Parton RG,Raposo G,Sens P,Lamaze C,Nassoy P

更新日期：2011-02-04 00:00:00

abstract：:In C. elegans, removing the germ cells extends life span by triggering the nuclear localization and activation of the DAF-16/FOXO transcription factor in the intestine. In this study, we identify and analyze genes required for germline removal to extend life span. We find that the reproductive system communicates with...

journal_title：Cell

authors： Berman JR,Kenyon C

更新日期：2006-03-10 00:00:00

abstract：:Ligand-directed signal bias offers opportunities for sculpting molecular events, with the promise of better, safer therapeutics. Critical to the exploitation of signal bias is an understanding of the molecular events coupling ligand binding to intracellular signaling. Activation of class B G protein-coupled receptors ...

journal_title：Cell

authors： Wootten D,Reynolds CA,Smith KJ,Mobarec JC,Koole C,Savage EE,Pabreja K,Simms J,Sridhar R,Furness SGB,Liu M,Thompson PE,Miller LJ,Christopoulos A,Sexton PM

更新日期：2016-06-16 00:00:00

abstract：:ROAM mutations cause overproduction in S. cerevisiae. Overproduction of ROAM mutant gene products is less in MATa/MAT alpha diploid strains which cannot conjugate than in haplolid strains which can. Overproduction occurs in diploid strains capable of mating whether or not they are capable of sporulating. Overproductio...

journal_title：Cell

authors： Errede B,Cardillo TS,Sherman F,Dubois E,Deschamps J,Wiame JM

更新日期：1980-11-01 00:00:00

abstract：:Kit/SCF signaling and Mitf-dependent transcription are both essential for melanocyte development and pigmentation. To identify Mitf-dependent Kit transcriptional targets in primary melanocytes, microarray studies were undertaken. Among identified targets was BCL2, whose germline deletion produces melanocyte loss and w...

journal_title：Cell

authors： McGill GG,Horstmann M,Widlund HR,Du J,Motyckova G,Nishimura EK,Lin YL,Ramaswamy S,Avery W,Ding HF,Jordan SA,Jackson IJ,Korsmeyer SJ,Golub TR,Fisher DE

更新日期：2002-06-14 00:00:00

abstract：:The genetics of complex disease produce alterations in the molecular interactions of cellular pathways whose collective effect may become clear through the organized structure of molecular networks. To characterize molecular systems associated with late-onset Alzheimer's disease (LOAD), we constructed gene-regulatory ...

journal_title：Cell

authors： Zhang B,Gaiteri C,Bodea LG,Wang Z,McElwee J,Podtelezhnikov AA,Zhang C,Xie T,Tran L,Dobrin R,Fluder E,Clurman B,Melquist S,Narayanan M,Suver C,Shah H,Mahajan M,Gillis T,Mysore J,MacDonald ME,Lamb JR,Bennett DA,

更新日期：2013-04-25 00:00:00

abstract：:Most human epithelial tumors harbor numerous alterations, making it difficult to predict which genes are required for tumor survival. To systematically identify cancer dependencies, we analyzed 501 genome-scale loss-of-function screens performed in diverse human cancer cell lines. We developed DEMETER, an analytical f...

journal_title：Cell

authors： Tsherniak A,Vazquez F,Montgomery PG,Weir BA,Kryukov G,Cowley GS,Gill S,Harrington WF,Pantel S,Krill-Burger JM,Meyers RM,Ali L,Goodale A,Lee Y,Jiang G,Hsiao J,Gerath WFJ,Howell S,Merkel E,Ghandi M,Garraway LA,Roo

更新日期：2017-07-27 00:00:00

abstract：:In order to identify nucleotide sequences required for efficient and accurate polyadenylation of mRNA precursors, we have constructed a series of mutations in the X. laevis beta 1-globin gene and analyzed transcripts produced upon microinjection into Xenopus oocytes. Small deletion and linker replacement mutations, wh...

journal_title：Cell

authors： Mason PJ,Elkington JA,Lloyd MM,Jones MB,Williams JG

更新日期：1986-07-18 00:00:00

abstract：:Pseudomonas exotoxin (PE) was used as a probe to study the mechanism by which protein ligands are internalized by mammalian cells. Both biochemical and electron microscopic methods were used to look at the internalization of PE by mouse LM cell fibroblasts. Our data suggest that PE enters cells by receptor-mediated en...

journal_title：Cell

authors： FitzGerald D,Morris RE,Saelinger CB

更新日期：1980-10-01 00:00:00

abstract：:We describe a monoclonal antibody directed against a neuron-specific mitochondrial protein from rat brain. On protein blots the antibody recognizes a single polypeptide of apparent molecular weight of 23,000. By solid-phase immunoassay the antigen was detected in nonneural tissues. Within neurons, the antibody stains ...

journal_title：Cell

authors： Hawkes R,Niday E,Matus A

更新日期：1982-02-01 00:00:00

abstract：:The growth of lymphatic vessels (lymphangiogenesis) is actively involved in a number of pathological processes including tissue inflammation and tumor dissemination but is insufficient in patients suffering from lymphedema, a debilitating condition characterized by chronic tissue edema and impaired immunity. The recen...

journal_title：Cell

authors： Tammela T,Alitalo K

更新日期：2010-02-19 00:00:00

abstract：:Stem cells are highly resistant to viral infection compared to their differentiated progeny; however, the mechanism is mysterious. Here, we analyzed gene expression in mammalian stem cells and cells at various stages of differentiation. We find that, conserved across species, stem cells express a subset of genes previ...

journal_title：Cell

authors： Wu X,Dao Thi VL,Huang Y,Billerbeck E,Saha D,Hoffmann HH,Wang Y,Silva LAV,Sarbanes S,Sun T,Andrus L,Yu Y,Quirk C,Li M,MacDonald MR,Schneider WM,An X,Rosenberg BR,Rice CM

更新日期：2018-01-25 00:00:00

abstract：:Regeneration of transected peripheral nerves is a complex process involving the coordinated action of neuronal axons, glial cells, and fibroblasts. Using rodent models of nerve repair, Parrinello et al. (2010) find that ephrin signaling between fibroblasts and Schwann cell progenitors, involving the stemness factor So...

journal_title：Cell

authors： Klein R

更新日期：2010-10-01 00:00:00

abstract：:The Rho family of GTPases control diverse biological processes, including cell morphology and mitogenesis. We have identified WASP, the protein that is defective in Wiskott-Aldrich syndrome (WAS), as a novel effector for CDC42Hs, but not for the other Rho family members, Rac and Rho. This interaction is dependent on t...

journal_title：Cell

authors： Symons M,Derry JM,Karlak B,Jiang S,Lemahieu V,Mccormick F,Francke U,Abo A

更新日期：1996-03-08 00:00:00

abstract：:The nucleotide sequence from the 5' terminus inward of one third of mouse alpha- and beta maj-globin messenger RNAs has been established. In addition, using 5' 32P end-labeled mRNAs as substrates and S1 and T1 nucleases as probes for single-stranded regions, the secondary structures of mouse and rabbit alpha- and beta...

journal_title：Cell

authors： Pavlakis GN,Lockard RE,Vamvakopoulos N,Rieser L,RajBhandary UL,Vournakis JN

更新日期：1980-01-01 00:00:00

abstract：:Phagosomes were traditionally thought to originate from an invagination and scission of the plasma membrane to form a distinct intracellular vacuole. An alternative model implicating the endoplasmic reticulum (ER) as a major component of nascent and maturing phagosomes was recently proposed (Gagnon et al., 2002). To r...

journal_title：Cell

authors： Touret N,Paroutis P,Terebiznik M,Harrison RE,Trombetta S,Pypaert M,Chow A,Jiang A,Shaw J,Yip C,Moore HP,van der Wel N,Houben D,Peters PJ,de Chastellier C,Mellman I,Grinstein S

更新日期：2005-10-07 00:00:00

abstract：:The trk tyrosine kinase proto-oncogene product gp140prototrk binds nerve growth factor (NGF) and is rapidly and selectively activated by this neurotrophic factor. To determine whether gp140prototrk is involved in transducing a functional NGF signal, PC12 cell mutants (PC12nnr) deficient in high affinity NGF binding an...

journal_title：Cell

authors： Loeb DM,Maragos J,Martin-Zanca D,Chao MV,Parada LF,Greene LA

更新日期：1991-09-06 00:00:00

abstract：:sigma(70) subunit is thought to be released from the core RNA polymerase (RNAP) upon the transition from initiation to elongation or shortly afterward. Here, we identify a population of RNAP from E. coli that retains sigma(70) throughout elongation. The relative amount of this population appears to depend on cellular ...

journal_title：Cell

authors： Bar-Nahum G,Nudler E

更新日期：2001-08-24 00:00:00

abstract：:In Drosophila melanogaster males, the sex chromosomes pair during meiosis in the centric X heterochromatin and at the base of the short arm of the Y (YS), in the vicinity of the nucleolus organizers. X chromosomes deficient for the pairing region segregate randomly from the Y. In this report we show that a single ribo...

journal_title：Cell

authors： McKee BD,Karpen GH

更新日期：1990-04-06 00:00:00

abstract：:The X-linked Foxp3 is a member of the forkhead/winged helix transcription factor family. Germline mutations cause lethal autoimmune diseases in males. Serendipitously, we observed that female mice heterozygous for the "scurfin" mutation of the Foxp3 gene (Foxp3(sf/+)) developed cancer at a high rate. The majority of t...

journal_title：Cell

authors： Zuo T,Wang L,Morrison C,Chang X,Zhang H,Li W,Liu Y,Wang Y,Liu X,Chan MW,Liu JQ,Love R,Liu CG,Godfrey V,Shen R,Huang TH,Yang T,Park BK,Wang CY,Zheng P,Liu Y

更新日期：2007-06-29 00:00:00

abstract：:Cancer cells have distinctive nutrient demands to fuel growth and proliferation, including the disproportionate use of glucose, glutamine, and fatty acids. Comerford et al. and Mashimo et al. now demonstrate that several types of cancer are avid consumers of acetate, which facilitates macromolecular biosynthesis and h...

journal_title：Cell

authors： Lyssiotis CA,Cantley LC

更新日期：2014-12-18 00:00:00

abstract：:The transport kinetics of the influenza virus hemagglutinin from its site of synthesis to the apical plasma membrane of Madin-Darby canine kidney cells, a polarized epithelial cell line, were studied by a sensitive tryptic assay. Hemagglutinin acquired terminal sugars, as judged by sensitivity to endo-beta-N-acetylglu...

journal_title：Cell

authors： Matlin KS,Simons K

更新日期：1983-08-01 00:00:00

abstract：:It is established that tumor cell-derived VEGF acts on endothelial cells to promote angiogenesis and tumor growth. Here, we demonstrate that in K5-SOS-dependent mouse skin tumors, autocrine VEGF is required for tumor cell proliferation in a cell-autonomous and angiogenesis-independent manner. VEGF is upregulated in SO...

journal_title：Cell

authors： Lichtenberger BM,Tan PK,Niederleithner H,Ferrara N,Petzelbauer P,Sibilia M

更新日期：2010-01-22 00:00:00

abstract：:The existence of pseudogenes and the observation of intron loss suggest that RNA can serve as an intermediate in recombination. We used a HIS3 reporter gene to show that RNA-mediated recombination occurs in yeast. His3+ prototroph formation required transcription and expression of the retrotransposon Ty. Two RNA-media...

journal_title：Cell

authors： Derr LK,Strathern JN,Garfinkel DJ

更新日期：1991-10-18 00:00:00

abstract：:Treatment of guinea pig neutrophils with pertussis toxin (islet-activating protein; IAP) results in inhibition of N-formyl peptide receptor-mediated release of arachidonic acid and granular enzymes. Inhibition by the toxin is specific, in that responses to the calcium ionophore A23187 are not affected. The action of t...

journal_title：Cell

authors： Bokoch GM,Gilman AG

更新日期：1984-12-01 00:00:00