Abstract:
:The functions of caveolae, the characteristic plasma membrane invaginations, remain debated. Their abundance in cells experiencing mechanical stress led us to investigate their role in membrane-mediated mechanical response. Acute mechanical stress induced by osmotic swelling or by uniaxial stretching results in a rapid disappearance of caveolae, in a reduced caveolin/Cavin1 interaction, and in an increase of free caveolins at the plasma membrane. Tether-pulling force measurements in cells and in plasma membrane spheres demonstrate that caveola flattening and disassembly is the primary actin- and ATP-independent cell response that buffers membrane tension surges during mechanical stress. Conversely, stress release leads to complete caveola reassembly in an actin- and ATP-dependent process. The absence of a functional caveola reservoir in myotubes from muscular dystrophic patients enhanced membrane fragility under mechanical stress. Our findings support a new role for caveolae as a physiological membrane reservoir that quickly accommodates sudden and acute mechanical stresses.
journal_name
Celljournal_title
Cellauthors
Sinha B,Köster D,Ruez R,Gonnord P,Bastiani M,Abankwa D,Stan RV,Butler-Browne G,Vedie B,Johannes L,Morone N,Parton RG,Raposo G,Sens P,Lamaze C,Nassoy Pdoi
10.1016/j.cell.2010.12.031subject
Has Abstractpub_date
2011-02-04 00:00:00pages
402-13issue
3eissn
0092-8674issn
1097-4172pii
S0092-8674(10)01523-0journal_volume
144pub_type
杂志文章相关文献
CELL文献大全abstract::Using insertional mutagenesis, we have isolated a "stalky" mutant in which cells destined to become spores end up as stalk cells. Similar mutants were previously observed after chemical mutagenesis, but the affected gene could not be isolated. Our mutant, like the previous ones, is in stkA. Its defect is cell-autonomo...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(00)81367-7
更新日期:1996-11-01 00:00:00
abstract::This year, the Lasker∼DeBakey Clinical Medical Research Award will be shared by Mahlon R. DeLong and Alim-Louis Benabid for elucidating the role of the subthalamic nucleus in mediating the motor dysfunction of Parkinson's disease and for pioneering the use of deep-brain stimulation to alleviate symptoms of the disease...
journal_title:Cell
pub_type: 传,历史文章,杂志文章
doi:10.1016/j.cell.2014.08.021
更新日期:2014-09-11 00:00:00
abstract::Spinal muscular atrophy (SMA) is an often fatal neuromuscular disease that has been directly linked to the protein product of the Survival of Motor Neurons (SMN) gene. The SMN protein is tightly associated with a novel protein, SIP1, and together they form a complex with several spliceosomal snRNP proteins. Here we sh...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(00)80368-2
更新日期:1997-09-19 00:00:00
abstract::Signaling by ErbB receptors requires the activation of their cytoplasmic kinase domains, which is initiated by ligand binding to the receptor ectodomains. Cytoplasmic factors contributing to the activation are unknown. Here we identify members of the cytohesin protein family as such factors. Cytohesin inhibition decre...
journal_title:Cell
pub_type: 杂志文章,收录出版
doi:10.1016/j.cell.2010.09.011
更新日期:2010-10-15 00:00:00
abstract::The triskelion shape of the clathrin molecule enables it to form the polyhedral protein network that covers clathrin-coated pits and vesicles. Domains within the clathrin heavy chain that are responsible for maintaining triskelion shape and function were identified and localized. Sequences that mediate trimerization a...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(92)90033-9
更新日期:1992-03-06 00:00:00
abstract::Spinal cord injuries alter motor function by disconnecting neural circuits above and below the lesion, rendering sensory inputs a primary source of direct external drive to neuronal networks caudal to the injury. Here, we studied mice lacking functional muscle spindle feedback to determine the role of this sensory cha...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2014.11.019
更新日期:2014-12-18 00:00:00
abstract::HNF-3 beta, a transcription factor of the winged-helix family, is expressed in embryonic and adult endoderm and also in midline cells of the node, notochord, and floor plate in mouse embryos. To define the function of HNF-3 beta, a targeted mutation in the HNF-3 beta locus was generated by homologous recombination in ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(94)90523-1
更新日期:1994-08-26 00:00:00
abstract::Pancreatic beta cell-surface expression of glucose transporter 2 (Glut-2) is essential for glucose-stimulated insulin secretion, thereby controlling blood glucose homeostasis in response to dietary intake. We show that the murine GlcNAcT-IVa glycosyltransferase is required for Glut-2 residency on the beta cell surface...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2005.09.041
更新日期:2005-12-29 00:00:00
abstract::We have determined the nucleotide sequence of a secondary lambda attachment site in trpC. Direct sequence analysis of lambdatrp transducing phage DNA fragments carrying the two prophage attachment sites reveals a 6 nucleotide homology in the crossover region which is a subset of the 15 nucleotide core sequence in the ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(79)90016-3
更新日期:1979-02-01 00:00:00
abstract::Ovule development in Arabidopsis involves the formation of three morphologically defined proximal-distal pattern elements. Integuments arise from the central pattern element. Analysis of Bell 1 (Bel 1) mutant ovules indicated that BEL1 was required for integument development. Cloning of the BEL1 locus reveals that it ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(95)90186-8
更新日期:1995-12-01 00:00:00
abstract::Autophagy is a catabolic process in which lysosomes degrade intracytoplasmic contents transported in double-membraned autophagosomes. Autophagosomes are formed by the elongation and fusion of phagophores, which can be derived from preautophagosomal structures coming from the plasma membrane and other sites like the en...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2011.06.023
更新日期:2011-07-22 00:00:00
abstract::Synapse formation requires changes in cell morphology and the upregulation and localization of synaptic proteins. In the cerebellum, mossy fibers undergo extensive remodeling as they contact several granule cells and form complex, multisynaptic glomerular rosettes. Here we show that granule cells secrete factors that ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(00)80689-3
更新日期:2000-03-03 00:00:00
abstract::The single, chloroplast encoded gene for the large subunit of ribulose-1,5-bisphosphate carboxylase/oxygenase (rbcL) from Euglena gracilis is found to contain nine intervening sequences. The intervening sequences were identified by heteroduplex analysis between Euglena rbcL and the non-intron-containing rbcL from Spin...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(84)90247-2
更新日期:1984-02-01 00:00:00
abstract::The brightness of our visual environment varies tremendously from day to night. In this issue of Cell, Milner and Do describe how the population of retinal neurons responsible for entrainment of the brain's circadian clock cooperate to encode irradiance across a wide range of ambient-light intensities. ...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2017.10.028
更新日期:2017-11-02 00:00:00
abstract::Receptor-interacting protein kinase (RIPK)-1 is involved in RIPK3-dependent and -independent signaling pathways leading to cell death and/or inflammation. Genetic ablation of ripk1 causes postnatal lethality, which was not prevented by deletion of ripk3, caspase-8, or fadd. However, animals that lack RIPK1, RIPK3, and...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2014.04.018
更新日期:2014-05-22 00:00:00
abstract::We show that expression of the iso-1-cytochrome c gene of Saccharomyces cerevisiae, CYC1, is tightly regulated by levels of intracellular heme. Expression is reduced at least 200-fold in cells grown under conditions of heme deficiency. Studies on the regulation of a CYC1-lacZ fused gene and direct determination of mRN...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(83)90309-4
更新日期:1983-04-01 00:00:00
abstract::Three different cases of pancreatic beta cell hyperplasia in mice are accompanied by an increase in a subclass of cells expressing tyrosine hydroxylase (TH), a neuronal enzyme. In the nontumorigenic cases of islet growth during normal pregnancy and in the obese mutant mouse, the TH-insulin cells do not divide, in cont...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(88)90534-x
更新日期:1988-01-15 00:00:00
abstract::Metastasis is the leading cause of cancer-associated death but has been difficult to study because it involves a series of rare, stochastic events. To capture these events, we developed a sensitive method to tag and track pancreatic epithelial cells in a mouse model of pancreatic cancer. Tagged cells invaded and enter...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2011.11.025
更新日期:2012-01-20 00:00:00
abstract::Induction of pluripotency in somatic cells has been achieved by myriad combinations of transcription factors that belong to the core pluripotency circuitry. In this issue, Shu et al. report reprogramming with lineage specifiers, lending support to the view of the pluripotent state as a fine balance between competing d...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2013.04.051
更新日期:2013-05-23 00:00:00
abstract::Certain mutant alleles at the low density lipoprotein (LDL) receptor locus produce receptors that bind LDL normally, but fail to cluster in coated pits and therefore cannot transport LDL into cells. We prepared genomic DNA libraries from cells of two individuals with this phenotype (internalization-defective familial ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(85)80054-4
更新日期:1985-07-01 00:00:00
abstract::The somatic 5S DNA from X. borealis (Xbs 5S DNA) and X. laevis (Xis 5S DNA) and a minor oocyte-specific 5S DNA from X. laevis (Xit 5S DNA) have been purified, and individual repeating units have been cloned and sequenced. The two somatic 5S DNAs differ from the major oocyte 5S DNAs in having GC-rich spacers, homogeneo...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(80)90241-x
更新日期:1980-05-01 00:00:00
abstract::The JAK/STAT signaling pathway, renowned for its effects on cell proliferation and survival, is constitutively active in various human cancers, including ovarian. We have found that JAK and STAT are required to convert the border cells in the Drosophila ovary from stationary, epithelial cells to migratory, invasive ce...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(01)00607-9
更新日期:2001-12-28 00:00:00
abstract::Protein phosphorylation and protein ubiquitination regulate most aspects of cell life, and defects in these control mechanisms cause cancer and many other diseases. In the past decade, protein kinases have become one of the most important classes of drug targets for the pharmaceutical industry. In contrast, drug disco...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2010.11.016
更新日期:2010-11-24 00:00:00
abstract::Electrophoretic and autoradiographic analyses of the incorporation of 35S--methionine into newly synthesized proteins during myogenesis reveal that presumptive chicken myoblasts synthesize primarily one intermediate filament protein: vimentin. Desmin synthesis is initiated at the onset of fusion. Synthesis rates of bo...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(80)90408-0
更新日期:1980-01-01 00:00:00
abstract::Polycomb group proteins control a hierarchy of gene expression during the differentiation of stem cells. In this issue, Ezhkova et al. (2009) show that repression mediated by Polycomb proteins controls the timing of differentiation of precursor cells of the epidermal lineage. ...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2009.03.004
更新日期:2009-03-20 00:00:00
abstract::The inhibitor of apoptosis (IAP) proteins suppress cell death by inhibiting the catalytic activity of caspases. Here we present the crystal structure of caspase-7 in complex with a potent inhibitory fragment from XIAP at 2.45 A resolution. An 18-residue XIAP peptide binds the catalytic groove of caspase-7, making exte...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(01)00272-0
更新日期:2001-03-09 00:00:00
abstract::The ephrin/Eph system plays a central role in neuronal circuit formation; however, its downstream effectors are poorly understood. Here we show that alpha-chimerin Rac GTPase-activating protein mediates ephrinB3/EphA4 forward signaling. We discovered a spontaneous mouse mutation, miffy (mfy), which results in a rabbit...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2007.07.022
更新日期:2007-08-24 00:00:00
abstract::The linear extrachromosomal ribosomal DNA of Tetrahymena is generated from a single integrated copy during macronuclear development. The free ends of this extrachromosomal gene contain 20-70 tandem repeats of the hexanucleotide CCCCAA. We have determined the nucleotide sequence at the same (3') end of the single, inte...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(82)90417-2
更新日期:1982-11-01 00:00:00
abstract::Junctions that connect the endoplasmic reticulum (ER) and the plasma membrane (PM) are unique yet ubiquitous subcellular compartments. Giordano et al. now report that extended synaptotagmins (E-Syts) promote their formation, providing fundamental insight into the molecular machinery controlling ER and plasma membrane ...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2013.05.054
更新日期:2013-06-20 00:00:00
abstract::Potassium channels embedded in cell membranes employ gates to regulate K+ current. While a specific constriction in the permeation pathway has historically been implicated in gating, recent reports suggest that the signature ion selectivity filter located in the outer membrane leaflet may be equally important. Inwardl...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2010.05.003
更新日期:2010-06-11 00:00:00