The SMN-SIP1 complex has an essential role in spliceosomal snRNP biogenesis.

abstract：:Certain mutant alleles at the low density lipoprotein (LDL) receptor locus produce receptors that bind LDL normally, but fail to cluster in coated pits and therefore cannot transport LDL into cells. We prepared genomic DNA libraries from cells of two individuals with this phenotype (internalization-defective familial ...

journal_title：Cell

authors： Lehrman MA,Goldstein JL,Brown MS,Russell DW,Schneider WJ

更新日期：1985-07-01 00:00:00

abstract：:Sucrose gradient analysis of DNA isolated from detergent-pronase lysates of adult flies has been used to look for ribosomal genes not integrated into the DNA of the chromosome in genotypes containing various combinations of inversions having breakpoints in the proximal heterochromatin of the X chromosome. Unintegrated...

journal_title：Cell

authors： Harford AG,Zuchowski CI

更新日期：1977-06-01 00:00:00

abstract：:We describe here a bizarre organization of the single large subunit (LSU) and small subunit (SSU) rRNA genes in the mitochondrial DNA of Chlamydomonas reinhardtii. Each gene is discontinuous, with gene pieces encoding specific rRNA domains ("modules") interspersed with one another and with intact protein coding and tR...

journal_title：Cell

authors： Boer PH,Gray MW

更新日期：1988-11-04 00:00:00

abstract：:We have obtained the complete sequence of cloned full-length DNA (NS DNA) derived from influenza virus gene 8, which codes for two unique polypeptides, NS1 and NS2, and the sequence of the NS2 mRNA. Previously we showed that the mRNA for NS1 (approximately 860 nucleotides) is colinear with the viral RNA and maps from ...

journal_title：Cell

authors： Lamb RA,Lai CJ

更新日期：1980-09-01 00:00:00

abstract：:During the SOS response, LexA repressor is inactivated by specific cleavage. Although cleavage requires RecA protein in vivo, RecA acts indirectly as a coprotease by stimulating an inherent self-cleavage activity of LexA. In lambda lysogens, cleavage of lambda Cl repressor in a similar but far slower reaction results ...

journal_title：Cell

authors： Kim B,Little JW

更新日期：1993-06-18 00:00:00

abstract：:To defend cells against viruses, the MAVS (mitochondrial antiviral signaling) adaptor protein initiates an antiviral signaling cascade from mitochondrial membranes. In this issue, Dixit et al. (2010) show that MAVS also localizes to the membranes of peroxisomes, where it rapidly induces expression of a subset of antiv...

journal_title：Cell

authors： Sharma S,Fitzgerald KA

更新日期：2010-05-14 00:00:00

abstract：:We determined the nucleotide sequences of all coding regions and a significant part of the flanking regions of the chicken c-src gene, which is a cellular homolog of the v-src gene of Rous sarcoma virus. The c-src gene consists of 12 exons; the boundaries of the exons were determined by assuming that the amino acid se...

journal_title：Cell

authors： Takeya T,Hanafusa H

更新日期：1983-03-01 00:00:00

abstract：:The 75 kDa tumor necrosis factor receptor (TNFR2) transduces extracellular signals via receptor-associated cytoplasmic proteins. Two of these signal transducers, TRAF1 and TRAF2, were isolated and characterized previously. We report here the biochemical purification and subsequent molecular cloning of two novel TNFR2-...

journal_title：Cell

authors： Rothe M,Pan MG,Henzel WJ,Ayres TM,Goeddel DV

更新日期：1995-12-29 00:00:00

abstract：:The large tumor antigen (LTag) of simian virus 40, an AAA(+) protein, is a hexameric helicase essential for viral DNA replication in eukaryotic cells. LTag functions as an efficient molecular machine powered by ATP binding and hydrolysis for origin DNA melting and replication fork unwinding. To understand how ATP bind...

journal_title：Cell

authors： Gai D,Zhao R,Li D,Finkielstein CV,Chen XS

更新日期：2004-10-01 00:00:00

abstract：:The lin-12 gene of C. elegans and the Notch gene of D. melanogaster encode structurally related transmembrane proteins that mediate intercellular signaling. We show that truncated forms of these proteins consisting of only the intracellular domains cause cell fate transformations associated with constitutive activity ...

journal_title：Cell

authors： Struhl G,Fitzgerald K,Greenwald I

更新日期：1993-07-30 00:00:00

abstract：:How transcription is silenced in early embryos has long been a mystery. In this issue, Guven-Ozkan et al. (2008) report that transcriptional repression during worm embryogenesis is mediated through sequestration of the general transcription factor TAF-4 and is regulated by mechanisms that orchestrate the transition be...

journal_title：Cell

authors： Blackwell TK,Walker AK

更新日期：2008-10-03 00:00:00

abstract：:The 2.2 kb mRNA of the Dictyostelium discoideum prespore gene EB4-PSV is constitutively transcribed during growth and development, but the message is only accumulated when cells form aggregates and establish the prespore-prestalk pattern. Disruption of the pattern by mechanical disaggregation results in a rapid loss o...

journal_title：Cell

authors： Hildebrandt M,Nellen W

更新日期：1992-04-03 00:00:00

abstract：:The posttranslational modification of proteins by methylglyoxal, a highly reactive compound derived from glycolysis, may contribute to aging, diabetes, and other disorders. In this issue of Cell, Brownlee and colleagues (Yao et al., 2006) demonstrate a specific mechanism by which methylglyoxal modifies a transcription...

journal_title：Cell

authors： Ramasamy R,Yan SF,Schmidt AM

更新日期：2006-01-27 00:00:00

abstract：:Ethylene regulates many aspects of plant growth and development. In the presence of ethylene, the C terminus of EIN2 (EIN2C) translocates into the nucleus and activates transcription. Li et al. and Merchante et al. show that EIN2C also regulates translation through an interaction with the 3' UTRs of transcripts. ...

journal_title：Cell

authors： Salehin M,Estelle M

更新日期：2015-10-22 00:00:00

abstract：:In Saccharomyces cerevisiae, mothers and daughters have distinct fates. We show that Cbk1 kinase and its interacting protein Mob2 regulate this asymmetry by inducing daughter-specific genetic programs. Daughter-specific expression is due to Cbk1/Mob2-dependent activation and localization of the Ace2 transcription fact...

journal_title：Cell

authors： Colman-Lerner A,Chin TE,Brent R

更新日期：2001-12-14 00:00:00

abstract：:Potassium channels embedded in cell membranes employ gates to regulate K+ current. While a specific constriction in the permeation pathway has historically been implicated in gating, recent reports suggest that the signature ion selectivity filter located in the outer membrane leaflet may be equally important. Inwardl...

journal_title：Cell

authors： Clarke OB,Caputo AT,Hill AP,Vandenberg JI,Smith BJ,Gulbis JM

更新日期：2010-06-11 00:00:00

abstract：:The adult male accessory glands of D. melanogaster synthesize and secrete a peptide that represses female sexual receptivity and stimulates oviposition. Normally, this peptide is transferred to females during copulation; however, the peptide shows the same biological activity after purification and subsequent injectio...

journal_title：Cell

authors： Chen PS,Stumm-Zollinger E,Aigaki T,Balmer J,Bienz M,Böhlen P

更新日期：1988-07-29 00:00:00

abstract：:During RNA interference (RNAi), Dicer generates short interfering RNAs (siRNAs), which then guide target mRNA cleavage by the RISC complex. Now, Liu et al. identify R2D2, a Dicer-associated protein that is important for siRNA incorporation into RISC, thus linking the initiation and execution phases of RNAi. ...

journal_title：Cell

authors： Pellino JL,Sontheimer EJ

更新日期：2003-10-17 00:00:00

abstract：:Insulin receptor (IR) signaling is central to normal metabolic control and dysregulated in prevalent chronic diseases. IR binds insulin at the cell surface and transduces rapid signaling via cytoplasmic kinases. However, mechanisms mediating long-term effects of insulin remain unclear. Here, we show that IR associates...

journal_title：Cell

authors： Hancock ML,Meyer RC,Mistry M,Khetani RS,Wagschal A,Shin T,Ho Sui SJ,Näär AM,Flanagan JG

更新日期：2019-04-18 00:00:00

abstract：:It has been long appreciated that, during meiosis, DNA replication is coordinated with the subsequent formation of the double-strand breaks (DSBs) that initiate recombination, but a mechanistic understanding of this process was elusive. We now show that, in yeast, the replisome-associated components Tof1 and Csm3 phys...

journal_title：Cell

authors： Murakami H,Keeney S

更新日期：2014-08-14 00:00:00

abstract：:The HVEM (TNFRSF14) receptor gene is among the most frequently mutated genes in germinal center lymphomas. We report that loss of HVEM leads to cell-autonomous activation of B cell proliferation and drives the development of GC lymphomas in vivo. HVEM-deficient lymphoma B cells also induce a tumor-supportive microenvi...

journal_title：Cell

authors： Boice M,Salloum D,Mourcin F,Sanghvi V,Amin R,Oricchio E,Jiang M,Mottok A,Denis-Lagache N,Ciriello G,Tam W,Teruya-Feldstein J,de Stanchina E,Chan WC,Malek SN,Ennishi D,Brentjens RJ,Gascoyne RD,Cogné M,Tarte K,Wende

更新日期：2016-10-06 00:00:00

abstract：:Syntaxin 1A plays a central role in neurotransmitter release through multiple protein-protein interactions. We have used NMR spectroscopy to identify an autonomously folded N-terminal domain in syntaxin 1A and to elucidate its three-dimensional structure. This 120-residue N-terminal domain is conserved in plasma membr...

journal_title：Cell

authors： Fernandez I,Ubach J,Dulubova I,Zhang X,Südhof TC,Rizo J

更新日期：1998-09-18 00:00:00

abstract：:Mobile DNAs have had a central role in shaping our genome. More than half of our DNA is comprised of interspersed repeats resulting from replicative copy and paste events of retrotransposons. Although most are fixed, incapable of templating new copies, there are important exceptions to retrotransposon quiescence. De n...

journal_title：Cell

authors： Burns KH,Boeke JD

更新日期：2012-05-11 00:00:00

abstract：:Drosophila chorion genes are located in two clusters, one on the X chromosome at 7F1-2 of the polytene chromosome map and a second on the third chromosome at 66D11-15. Genes in both regions undergo amplification in ovarian follicle cells prior to their expression late in oogenesis. Analysis of cloned genomic segments ...

journal_title：Cell

authors： Spradling AC

更新日期：1981-11-01 00:00:00

abstract：:IFN-γ-activated macrophages attempt to limit pathogen growth through tryptophan starvation. Zhang et al. demonstrate that Mycobacterium tuberculosis responds to this threat by synthesizing its own tryptophan. Genetic and chemical inhibition of this pathway reduces mycobacterial survival, revealing a new immune-depende...

journal_title：Cell

authors： Russell DG

更新日期：2013-12-05 00:00:00

abstract：:Specific active transcription units on chromosome IV in the salivary glands of Chironomus tentans have been visualized by the Miller spreading technique and in situ by conventional electron microscopy. These units are likely to be located in the two most conspicuous puffs on chromosome IV, Balbiani ring 1 (BR 1) and B...

journal_title：Cell

authors： Lamb MM,Daneholt B

更新日期：1979-08-01 00:00:00

abstract：:We present the first isolation of the terminal DNA of an intact Drosophila telomere. It differs from those isolated from other eukaryotes by the lack of short tandem repeats at the terminus. The terminal 14.5 kb is composed of four tandem elements derived from two families of non-long terminal repeat retrotransposons ...

journal_title：Cell

authors： Levis RW,Ganesan R,Houtchens K,Tolar LA,Sheen FM

更新日期：1993-12-17 00:00:00

abstract：:Mycobacteria are unusual in encoding two GroEL paralogs, GroEL1 and GroEL2. GroEL2 is essential--presumably providing the housekeeping chaperone functions--while groEL1 is nonessential, contains the attB site for phage Bxb1 integration, and encodes a putative chaperone with unusual structural features. Inactivation of...

journal_title：Cell

authors： Ojha A,Anand M,Bhatt A,Kremer L,Jacobs WR Jr,Hatfull GF

更新日期：2005-12-02 00:00:00

abstract：:One of the important events in synapse formation is the accumulation of neurotransmitter receptors beneath the presynaptic nerve terminal. Agrin is a component of the synaptic basal lamina that induces the clustering of acetylcholine receptors when bath-applied to muscle fibers in culture. When a cDNA encoding a putat...

journal_title：Cell

authors： Campanelli JT,Hoch W,Rupp F,Kreiner T,Scheller RH

更新日期：1991-11-29 00:00:00

abstract：:The nucleus is connected to the cytoskeleton, and these connections are involved in multiple functions such as nuclear positioning, shape and stiffness, cytoskeleton organization, mechanotransduction, gene expression, chromosome positioning, DNA repair, and cell migration. ...

journal_title：Cell

authors： Janota CS,Calero-Cuenca FJ,Costa J,Gomes ER

更新日期：2017-05-18 00:00:00