OMA-gosh, where's that TAF?

abstract：:The asymmetries of internal organs are consistently oriented along the left-right axis in all vertebrates, and perturbations of left-right orientation lead to significant congenital disease. We propose a model in which a "left-right coordinator" interacts with the Spemann organizer to coordinate the evolutionarily con...

journal_title：Cell

authors： Hyatt BA,Yost HJ

更新日期：1998-04-03 00:00:00

abstract：:We show that transfer of human fibroblast chromosome 11 (containing the human MyoD gene) from primary cells into 10T1/2 mouse fibroblasts by microcell fusion activates expression of the transferred human MyoD gene and converts these cells to myoblasts. Transfer of human chromosome 11 into B78 melanoma cells also leads...

journal_title：Cell

authors： Thayer MJ,Weintraub H

更新日期：1990-10-05 00:00:00

abstract：:The sigma factor sigma 70 of E. coli RNA polymerase acts not only in initiation, but also at an early stage of elongation to induce a transcription pause, and simultaneously to allow the phage lambda gene Q transcription antiterminator to act. We identify the signal in DNA that induces early pausing to be a version of...

journal_title：Cell

authors： Ring BZ,Yarnell WS,Roberts JW

更新日期：1996-08-09 00:00:00

abstract：:Proteotypes, like genotypes, have been found to vary between individuals in several studies, but consistent molecular functional traits across studies remain to be quantified. In a meta-analysis of 11 proteomics datasets from humans and mice, we use co-variation of proteins in known functional modules across datasets ...

journal_title：Cell

authors： Romanov N,Kuhn M,Aebersold R,Ori A,Beck M,Bork P

更新日期：2019-05-16 00:00:00

abstract：:A recent series of papers, including Festa et al. (2011) in this issue, has revealed unexpected interdependent relationships among cell populations residing in and around the hair follicle. These interactions between different lineages of stem cells are crucial for hair follicle growth and cycling and point to a compl...

journal_title：Cell

authors： Jahoda CA,Christiano AM

更新日期：2011-09-02 00:00:00

abstract：:Membrane scission is essential for intracellular trafficking. While BAR domain proteins such as endophilin have been reported in dynamin-independent scission of tubular membrane necks, the cutting mechanism has yet to be deciphered. Here, we combine a theoretical model, in vitro, and in vivo experiments revealing how ...

journal_title：Cell

authors： Simunovic M,Manneville JB,Renard HF,Evergren E,Raghunathan K,Bhatia D,Kenworthy AK,Voth GA,Prost J,McMahon HT,Johannes L,Bassereau P,Callan-Jones A

更新日期：2017-06-29 00:00:00

abstract：:We have shown that the DNA sequences adjacent to the telomeres of Saccharomyces cerevisiae chromosomes are highly conserved and contain a high density of replication origins. The salient features of these telomeres can be summarized as follows. There are three moderately repetitive elements present at the telomeres: t...

journal_title：Cell

authors： Chan CS,Tye BK

更新日期：1983-06-01 00:00:00

abstract：:Elements controlling tissue-specific expression of the rat albumin gene reside within roughly 150 bp upstream of the transcriptional initiation site. We show here by DNAase I footprinting assays that at least four distinct factors present in extracts derived from cells expressing albumin interact with these sequences....

journal_title：Cell

authors： Cereghini S,Raymondjean M,Carranca AG,Herbomel P,Yaniv M

更新日期：1987-08-14 00:00:00

abstract：:Models of transcription are often built around a picture of RNA polymerase and transcription factors (TFs) acting on a single copy of a promoter. However, most TFs are shared between multiple genes with varying binding affinities. Beyond that, genes often exist at high copy number-in multiple identical copies on the c...

journal_title：Cell

authors： Brewster RC,Weinert FM,Garcia HG,Song D,Rydenfelt M,Phillips R

更新日期：2014-03-13 00:00:00

abstract：:While developing an assay to measure the activity of the tat protein from human immunodeficiency virus 1 (HIV-1), we discovered that the purified protein could be taken up by cells growing in tissue culture and subsequently trans-activate the viral promoter. Trans-activation is dramatically increased by a variety of l...

journal_title：Cell

authors： Frankel AD,Pabo CO

更新日期：1988-12-23 00:00:00

abstract：:In the nucleus of eukaryotic cells, RNA decay in the 3'-5' direction is carried out by a complex of exonucleases called the exosome. Surprisingly, the purified exosome shows only weak activity in vitro. Two papers in this issue of Cell, by LaCava et al. (2005) and Wyers et al. (2005), and a third report by Vanacova et...

journal_title：Cell

authors： Jensen TH,Moore C

更新日期：2005-06-03 00:00:00

abstract：:Based on the above mechanisms of mRNA degradation, an integrated model of mRNA turnover can be proposed (Figure 1). In this model, all polyadenylated mRNAs would be degraded by the deadenylation-dependent pathway at some rate. In addition to this default pathway, another layer of complexity would come from degradation...

journal_title：Cell

authors： Beelman CA,Parker R

更新日期：1995-04-21 00:00:00

abstract：:Despite all modern advances in medicine, an effective drug treatment of obesity has not been found yet. Discovery of leptin two decades ago created hopes for treatment of obesity. However, development of leptin resistance has been a big obstacle, mitigating a leptin-centric treatment of obesity. Here, by using in sili...

journal_title：Cell

authors： Liu J,Lee J,Salazar Hernandez MA,Mazitschek R,Ozcan U

更新日期：2015-05-21 00:00:00

abstract：:We report the discovery of a short-lived chaperone that is required for the correct maturation of the eukaryotic 20S proteasome and is destroyed at a specific stage of the assembly process. The S. cerevisiae Ump1p protein is a component of proteasome precursor complexes containing unprocessed beta subunits but is not ...

journal_title：Cell

authors： Ramos PC,Höckendorff J,Johnson ES,Varshavsky A,Dohmen RJ

更新日期：1998-02-20 00:00:00

abstract：:A complete human gamma 1 heavy chain gene (HIG1) was transferred into mouse cells by protoplast fusion. The HIG1 gene was strongly expressed in mouse myeloma cells but not in mouse fibroblasts (L cells). Nuclear extracts from myeloma cells were injected into L cell transformants containing one copy of the HIG1 gene; t...

journal_title：Cell

authors： Maeda H,Kitamura D,Kudo A,Araki K,Watanabe T

更新日期：1986-04-11 00:00:00

abstract：:Expression of pipe in the somatic tissue of the Drosophila ovary is required for the formation of embryonic dorsal-ventral polarity. pipe, which encodes an enzyme similar to the glycosaminoglycan-modifying enzyme heparan sulfate 2-O-sulfotransferase, is expressed in a spatially restricted domain of follicle cells on t...

journal_title：Cell

authors： Sen J,Goltz JS,Stevens L,Stein D

更新日期：1998-11-13 00:00:00

abstract：:The JAK/STAT signaling pathway, renowned for its effects on cell proliferation and survival, is constitutively active in various human cancers, including ovarian. We have found that JAK and STAT are required to convert the border cells in the Drosophila ovary from stationary, epithelial cells to migratory, invasive ce...

journal_title：Cell

authors： Silver DL,Montell DJ

更新日期：2001-12-28 00:00:00

abstract：:RNA-guided Cas9 endonucleases protect bacteria from viral infection and have been creatively repurposed as programmable molecular scalpels for surgical manipulation of DNA. Now, two papers in Cell (Pawluk et al. and Rauch et al.) identify viral proteins that suppress Cas9 and may function like molecular sheaths for th...

journal_title：Cell

authors： Carter J,Hoffman C,Wiedenheft B

更新日期：2017-01-12 00:00:00

abstract：:A functional cDNA from Aspergillus nidulans encoding triosephosphate isomerase (TPI) was isolated by its ability to complement a tpi1 mutation in Saccharomyces cerevisiae. This cDNA was used to obtain the corresponding gene, tpiA. Alignment of the cDNA and genomic DNA nucleotide sequences indicated that tpiA contains ...

journal_title：Cell

authors： McKnight GL,O'Hara PJ,Parker ML

更新日期：1986-07-04 00:00:00

abstract：:To reconstruct modern human evolutionary history and identify loci that have shaped hunter-gatherer adaptation, we sequenced the whole genomes of five individuals in each of three different hunter-gatherer populations at > 60× coverage: Pygmies from Cameroon and Khoesan-speaking Hadza and Sandawe from Tanzania. We ide...

journal_title：Cell

authors： Lachance J,Vernot B,Elbers CC,Ferwerda B,Froment A,Bodo JM,Lema G,Fu W,Nyambo TB,Rebbeck TR,Zhang K,Akey JM,Tishkoff SA

更新日期：2012-08-03 00:00:00

abstract：:Rho and rac, two members of the ras-related superfamily of small GTPases, regulate the polymerization of actin to produce stress fibers and lamellipodia, respectively. We report here that cdc42, another member of the rho family, triggers the formation of a third type of actin-based structure found at the cell peripher...

journal_title：Cell

authors： Nobes CD,Hall A

更新日期：1995-04-07 00:00:00

abstract：:N(6)-methyladenosine (m(6)A) is the most abundant internal modification of messenger RNA. While the presence of m(6)A on transcripts can impact nuclear RNA fates, a reader of this mark that mediates processing of nuclear transcripts has not been identified. We find that the RNA-binding protein HNRNPA2B1 binds m(6)A-be...

journal_title：Cell

authors： Alarcón CR,Goodarzi H,Lee H,Liu X,Tavazoie S,Tavazoie SF

更新日期：2015-09-10 00:00:00

abstract：:Many organisms expand the information content of their genome through enzymatic methylation of cytosine residues. Here we report the 2.8 A crystal structure of a bacterial DNA (cytosine-5)-methyltransferase (DCMtase), M. HaeIII, bound covalently to DNA. In this complex, the substrate cytosine is extruded from the DNA ...

journal_title：Cell

authors： Reinisch KM,Chen L,Verdine GL,Lipscomb WN

更新日期：1995-07-14 00:00:00

abstract：:The hallmarks of cancer comprise six biological capabilities acquired during the multistep development of human tumors. The hallmarks constitute an organizing principle for rationalizing the complexities of neoplastic disease. They include sustaining proliferative signaling, evading growth suppressors, resisting cell ...

journal_title：Cell

authors： Hanahan D,Weinberg RA

更新日期：2011-03-04 00:00:00

abstract：:Microbial functions in the host physiology are a result of the microbiota-host co-evolution. We show that cold exposure leads to marked shift of the microbiota composition, referred to as cold microbiota. Transplantation of the cold microbiota to germ-free mice is sufficient to increase insulin sensitivity of the host...

journal_title：Cell

authors： Chevalier C,Stojanović O,Colin DJ,Suarez-Zamorano N,Tarallo V,Veyrat-Durebex C,Rigo D,Fabbiano S,Stevanović A,Hagemann S,Montet X,Seimbille Y,Zamboni N,Hapfelmeier S,Trajkovski M

更新日期：2015-12-03 00:00:00

abstract：:Trigger factor is a soluble, 63,000 dalton protein of E. coli that stabilizes proOmpA, the precursor form of a major outer-membrane protein, in a conformation competent for in vitro membrane assembly. There is approximately one trigger factor molecule bound to each 70S ribosome isolated from cell extracts in physiolog...

journal_title：Cell

authors： Lill R,Crooke E,Guthrie B,Wickner W

更新日期：1988-09-23 00:00:00

abstract：:Competence development and sporulation in B. subtilis are partly controlled by peptides that accumulate in culture medium as cells grow to high density. We constructed two genes that encode mature forms of two different signaling molecules, the PhrA peptide that stimulates sporulation, and CSF, the competence- and spo...

journal_title：Cell

authors： Lazazzera BA,Solomon JM,Grossman AD

更新日期：1997-06-13 00:00:00

abstract：:Autophagy is a catabolic process in which lysosomes degrade intracytoplasmic contents transported in double-membraned autophagosomes. Autophagosomes are formed by the elongation and fusion of phagophores, which can be derived from preautophagosomal structures coming from the plasma membrane and other sites like the en...

journal_title：Cell

authors： Moreau K,Ravikumar B,Renna M,Puri C,Rubinsztein DC

更新日期：2011-07-22 00:00:00

abstract：:Using insertional mutagenesis, we have isolated a "stalky" mutant in which cells destined to become spores end up as stalk cells. Similar mutants were previously observed after chemical mutagenesis, but the affected gene could not be isolated. Our mutant, like the previous ones, is in stkA. Its defect is cell-autonomo...

journal_title：Cell

authors： Chang WT,Newell PC,Gross JD

更新日期：1996-11-01 00:00:00

abstract：:Retroviral DNA integration involves a coordinated set of DNA cutting and joining reactions. We find that the IN protein of Moloney murine leukemia virus (MoMLV) is the only viral protein required to accomplish these reactions in vitro. IN protein has a site-specific nuclease activity that cleaves 2 nucleotides from th...

journal_title：Cell

authors： Craigie R,Fujiwara T,Bushman F

更新日期：1990-08-24 00:00:00