当前位置： SCI文献检索 > CELL期刊下所有文献 > Nucleotide sequence of the triosephosphate isomerase gene from Aspergillus nidulans: implications for a differential loss of introns.

Nucleotide sequence of the triosephosphate isomerase gene from Aspergillus nidulans: implications for a differential loss of introns.

Abstract：

:A functional cDNA from Aspergillus nidulans encoding triosephosphate isomerase (TPI) was isolated by its ability to complement a tpi1 mutation in Saccharomyces cerevisiae. This cDNA was used to obtain the corresponding gene, tpiA. Alignment of the cDNA and genomic DNA nucleotide sequences indicated that tpiA contains five introns. The intron positions in the tpiA gene were compared with those in the TPI genes of human, chicken, and maize. One intron is present at an identical position in all four organisms, two other introns are located in similar positions in A. nidulans and maize, and the remaining two introns are unique to A. nidulans. These Aspergillus-specific introns are located in regions of the protein that were predicted to be interrupted by introns based on analysis of a Go plot of chicken TPI. These comparisons are discussed in relation to the evolution of introns within TPI genes.

journal_name

Cell

journal_title

Cell

authors

McKnight GL,O'Hara PJ,Parker ML

doi

10.1016/0092-8674(86)90868-8

subject

Has Abstract

pub_date

1986-07-04 00:00:00

pages

143-7

issue

1

eissn

0092-8674

issn

1097-4172

pii

0092-8674(86)90868-8

journal_volume

46

pub_type

杂志文章

相关文献

CELL文献大全
  • Novel partitioning of DNA cleavage sites for Drosophila topoisomerase II.

    abstract：:We have examined the long-range distribution of double-stranded DNA cleavage sites for Drosophila melanogaster topoisomerase II. These studies reveal a novel partitioning of preferred topoisomerase II cleavage sites. In the eukaryotic DNAs examined, major cleavage sites were typically found in nontranscribed spacer se...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/0092-8674(85)90353-8

    authors： Udvardy A,Schedl P,Sander M,Hsieh TS

    更新日期：1985-04-01 00:00:00

  • Internalization-defective LDL receptors produced by genes with nonsense and frameshift mutations that truncate the cytoplasmic domain.

    abstract：:Certain mutant alleles at the low density lipoprotein (LDL) receptor locus produce receptors that bind LDL normally, but fail to cluster in coated pits and therefore cannot transport LDL into cells. We prepared genomic DNA libraries from cells of two individuals with this phenotype (internalization-defective familial ...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/s0092-8674(85)80054-4

    authors： Lehrman MA,Goldstein JL,Brown MS,Russell DW,Schneider WJ

    更新日期：1985-07-01 00:00:00

  • Inherited human Caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II.

    abstract：:Caspases are cysteine proteases that mediate programmed cell death in phylogenetically diverse multicellular organisms. We report here two kindreds with autoimmune lymphoproliferative syndrome (ALPS) type II, characterized by abnormal lymphocyte and dendritic cell homeostasis and immune regulatory defects, that harbor...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/S0092-8674(00)80605-4

    authors： Wang J,Zheng L,Lobito A,Chan FK,Dale J,Sneller M,Yao X,Puck JM,Straus SE,Lenardo MJ

    更新日期：1999-07-09 00:00:00

  • An Atomic Structure of the Human Spliceosome.

    abstract：:Mechanistic understanding of pre-mRNA splicing requires detailed structural information on various states of the spliceosome. Here we report the cryo electron microscopy (cryo-EM) structure of the human spliceosome just before exon ligation (the C∗ complex) at an average resolution of 3.76 Å. The splicing factor Prp17...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2017.04.033

    authors： Zhang X,Yan C,Hang J,Finci LI,Lei J,Shi Y

    更新日期：2017-05-18 00:00:00

  • Adaptation to P element transposon invasion in Drosophila melanogaster.

    abstract：:Transposons evolve rapidly and can mobilize and trigger genetic instability. Piwi-interacting RNAs (piRNAs) silence these genome pathogens, but it is unclear how the piRNA pathway adapts to invasion of new transposons. In Drosophila, piRNAs are encoded by heterochromatic clusters and maternally deposited in the embryo...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2011.11.042

    authors： Khurana JS,Wang J,Xu J,Koppetsch BS,Thomson TC,Nowosielska A,Li C,Zamore PD,Weng Z,Theurkauf WE

    更新日期：2011-12-23 00:00:00

  • Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations.

    abstract：:Macroautophagy is a lysosomal degradative pathway essential for neuron survival. Here, we show that macroautophagy requires the Alzheimer's disease (AD)-related protein presenilin-1 (PS1). In PS1 null blastocysts, neurons from mice hypomorphic for PS1 or conditionally depleted of PS1, substrate proteolysis and autopha...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2010.05.008

    authors： Lee JH,Yu WH,Kumar A,Lee S,Mohan PS,Peterhoff CM,Wolfe DM,Martinez-Vicente M,Massey AC,Sovak G,Uchiyama Y,Westaway D,Cuervo AM,Nixon RA

    更新日期：2010-06-25 00:00:00

  • Evolutionary history and adaptation from high-coverage whole-genome sequences of diverse African hunter-gatherers.

    abstract：:To reconstruct modern human evolutionary history and identify loci that have shaped hunter-gatherer adaptation, we sequenced the whole genomes of five individuals in each of three different hunter-gatherer populations at > 60× coverage: Pygmies from Cameroon and Khoesan-speaking Hadza and Sandawe from Tanzania. We ide...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2012.07.009

    authors： Lachance J,Vernot B,Elbers CC,Ferwerda B,Froment A,Bodo JM,Lema G,Fu W,Nyambo TB,Rebbeck TR,Zhang K,Akey JM,Tishkoff SA

    更新日期：2012-08-03 00:00:00

  • Regulation of fibronectin biosynthesis by glucocorticoids in human fibrosarcoma cells and normal fibroblasts.

    abstract：:When treated with the synthetic glucocorticoid dexamethasone, HT1080 human fibrosarcoma cells show changes in morphology, adhesion, and the extracellular matrix. Dexamethasone treatment results in a tenfold increase in the rate of fibronectin biosynthesis in HT1080 cells and a twofold increase in untransformed, normal...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/0092-8674(83)90357-4

    authors： Oliver N,Newby RF,Furcht LT,Bourgeois S

    更新日期：1983-05-01 00:00:00

  • A nanobody-based system using fluorescent proteins as scaffolds for cell-specific gene manipulation.

    abstract：:Fluorescent proteins are commonly used to label cells across organisms, but the unmodified forms cannot control biological activities. Using GFP-binding proteins derived from Camelid antibodies, we co-opted GFP as a scaffold for inducing formation of biologically active complexes, developing a library of hybrid transc...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2013.07.021

    authors： Tang JC,Szikra T,Kozorovitskiy Y,Teixiera M,Sabatini BL,Roska B,Cepko CL

    更新日期：2013-08-15 00:00:00

  • The mechanism of RNA recombination in poliovirus.

    abstract：:We have investigated RNA recombination among poliovirus genomes by analyzing both intratypic and intertypic recombinant crosses involving the same defined genetic markers. Sequence analysis of the recombinant junctions of 13 nonsibling intertypic recombinants showed that intertypic RNA recombination is not site-specif...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/0092-8674(86)90600-8

    authors： Kirkegaard K,Baltimore D

    更新日期：1986-11-07 00:00:00

  • The V beta-specific superantigen staphylococcal enterotoxin B: stimulation of mature T cells and clonal deletion in neonatal mice.

    abstract：:Staphylococcal enterotoxin B is known to be a powerful T cell stimulant in mouse and man. In this paper we show that, for mice, this is because the protein in association with major histocompatibility complex class II molecules stimulates virtually all T cells bearing V beta 3 and V beta 8.1, 8.2, and 8.3, and few oth...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/0092-8674(89)90980-x

    authors： White J,Herman A,Pullen AM,Kubo R,Kappler JW,Marrack P

    更新日期：1989-01-13 00:00:00

  • Interaction of fibronectin with its receptor on platelets.

    abstract：:We report that the 12,000 dalton domain of fibronectin that interacts with fibroblast cell surfaces also binds specifically to thrombin-inducible, saturable receptors on platelets. Furthermore, we have used chemical cross-linking and monoclonal antibodies to show that the 12,000 dalton domain of fibronectin interacts ...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/0092-8674(85)90101-1

    authors： Gardner JM,Hynes RO

    更新日期：1985-09-01 00:00:00

  • Connecting the dots between septins and the DNA damage checkpoint.

    abstract：:In budding yeast, septins are involved in the morphogenesis checkpoint and the DNA damage checkpoint, both of which regulate cell-cycle progression. In this issue of Cell, Kremer et al. (2007) link septins to DNA damage in mammalian cells by identifying a new signaling pathway that includes the adaptors SOCS7 and NCK....

    journal_title：Cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.cell.2007.08.022

    authors： Kinoshita M,Takeda S

    更新日期：2007-09-07 00:00:00

  • Species-dependent posttranscriptional regulation of NOS1 by FMRP in the developing cerebral cortex.

    abstract：:Fragile X syndrome (FXS), the leading monogenic cause of intellectual disability and autism, results from loss of function of the RNA-binding protein FMRP. Here, we show that FMRP regulates translation of neuronal nitric oxide synthase 1 (NOS1) in the developing human neocortex. Whereas NOS1 mRNA is widely expressed, ...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2012.02.060

    authors： Kwan KY,Lam MM,Johnson MB,Dube U,Shim S,Rašin MR,Sousa AM,Fertuzinhos S,Chen JG,Arellano JI,Chan DW,Pletikos M,Vasung L,Rowitch DH,Huang EJ,Schwartz ML,Willemsen R,Oostra BA,Rakic P,Heffer M,Kostović I,Judaš M,

    更新日期：2012-05-11 00:00:00

  • Parafibromin/Hyrax activates Wnt/Wg target gene transcription by direct association with beta-catenin/Armadillo.

    abstract：:The Wnt pathway controls cell fates, tissue homeostasis, and cancer. Its activation entails the association of beta-catenin with nuclear TCF/LEF proteins and results in transcriptional activation of target genes. The mechanism by which nuclear beta-catenin controls transcription is largely unknown. Here we genetically...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2006.01.053

    authors： Mosimann C,Hausmann G,Basler K

    更新日期：2006-04-21 00:00:00

  • PAR-1 kinase plays an initiator role in a temporally ordered phosphorylation process that confers tau toxicity in Drosophila.

    abstract：:Multisite hyperphosphorylation of tau has been implicated in the pathogenesis of neurodegenerative diseases including Alzheimer's disease (AD). However, the phosphorylation events critical for tau toxicity and mechanisms regulating these events are largely unknown. Here we show that Drosophila PAR-1 kinase initiates t...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/s0092-8674(04)00170-9

    authors： Nishimura I,Yang Y,Lu B

    更新日期：2004-03-05 00:00:00

  • Follicular dendritic cells emerge from ubiquitous perivascular precursors.

    abstract：:The differentiation of follicular dendritic cells (FDC) is essential to the remarkable microanatomic plasticity of lymphoid follicles. Here we show that FDC arise from ubiquitous perivascular precursors (preFDC) expressing platelet-derived growth factor receptor β (PDGFRβ). PDGFRβ-Cre-driven reporter gene recombinatio...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2012.05.032

    authors： Krautler NJ,Kana V,Kranich J,Tian Y,Perera D,Lemm D,Schwarz P,Armulik A,Browning JL,Tallquist M,Buch T,Oliveira-Martins JB,Zhu C,Hermann M,Wagner U,Brink R,Heikenwalder M,Aguzzi A

    更新日期：2012-07-06 00:00:00

  • Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells.

    abstract：:We mutated, by gene targeting, the endogenous hypoxanthine phosphoribosyl transferase (HPRT) gene in mouse embryo-derived stem (ES) cells. A specialized construct of the neomycin resistance (neor) gene was introduced into an exon of a cloned fragment of the Hprt gene and used to transfect ES cells. Among the G418r col...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/0092-8674(87)90646-5

    authors： Thomas KR,Capecchi MR

    更新日期：1987-11-06 00:00:00

  • Complement C1q activates canonical Wnt signaling and promotes aging-related phenotypes.

    abstract：:Wnt signaling plays critical roles in development of various organs and pathogenesis of many diseases, and augmented Wnt signaling has recently been implicated in mammalian aging and aging-related phenotypes. We here report that complement C1q activates canonical Wnt signaling and promotes aging-associated decline in ...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2012.03.047

    authors： Naito AT,Sumida T,Nomura S,Liu ML,Higo T,Nakagawa A,Okada K,Sakai T,Hashimoto A,Hara Y,Shimizu I,Zhu W,Toko H,Katada A,Akazawa H,Oka T,Lee JK,Minamino T,Nagai T,Walsh K,Kikuchi A,Matsumoto M,Botto M,Shiojima

    更新日期：2012-06-08 00:00:00

  • Genetic isolation of ADA2: a potential transcriptional adaptor required for function of certain acidic activation domains.

    abstract：:We have devised a genetic strategy to isolate the target of acidic activation domains of transcriptional activators based on toxicity in yeast cells of the chimeric activator, GAL4-VP16. Toxicity required the integrity of both the VP16 acidic activation domain and the GAL4 DNA-binding domain, suggesting that inhibitio...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/0092-8674(92)90100-q

    authors： Berger SL,Piña B,Silverman N,Marcus GA,Agapite J,Regier JL,Triezenberg SJ,Guarente L

    更新日期：1992-07-24 00:00:00

  • A polymorphism in CALHM1 influences Ca2+ homeostasis, Abeta levels, and Alzheimer's disease risk.

    abstract：:Alzheimer's disease (AD) is a genetically heterogeneous disorder characterized by early hippocampal atrophy and cerebral amyloid-beta (Abeta) peptide deposition. Using TissueInfo to screen for genes preferentially expressed in the hippocampus and located in AD linkage regions, we identified a gene on 10q24.33 that we ...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2008.05.048

    authors： Dreses-Werringloer U,Lambert JC,Vingtdeux V,Zhao H,Vais H,Siebert A,Jain A,Koppel J,Rovelet-Lecrux A,Hannequin D,Pasquier F,Galimberti D,Scarpini E,Mann D,Lendon C,Campion D,Amouyel P,Davies P,Foskett JK,Campagne F

    更新日期：2008-06-27 00:00:00

  • Cis-trans test shows a functional relationship between non-allelic lethal mutations in the T/t-complex.

    abstract：:Recessive lethal mutations in the T/t-complex of the mouse characteristically show defective genetic complementation, even when they affect very different stages of embryogenesis and are known to be nonallelic. To address the question of their genetic or functional relationship, we have applied the cis-trans test, usi...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/0092-8674(83)90035-1

    authors： Shin HS,McCormick P,Artzt K,Bennett D

    更新日期：1983-07-01 00:00:00

  • Analysis of Human Sequence Data Reveals Two Pulses of Archaic Denisovan Admixture.

    abstract：:Anatomically modern humans interbred with Neanderthals and with a related archaic population known as Denisovans. Genomes of several Neanderthals and one Denisovan have been sequenced, and these reference genomes have been used to detect introgressed genetic material in present-day human genomes. Segments of introgres...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2018.02.031

    authors： Browning SR,Browning BL,Zhou Y,Tucci S,Akey JM

    更新日期：2018-03-22 00:00:00

  • Autophagy: paying Charon's toll.

    abstract：:Autophagy (literally self-eating) has diverse cytoprotective functions but also is linked to programmed cell death (PCD). In this issue, Qu et al. (2007) analyze the role of autophagy in PCD during development. Unexpectedly they find that autophagy induces apoptotic cells to present a signal to ensure their clearance,...

    journal_title：Cell

    pub_type： 评论,杂志文章,评审

    doi：10.1016/j.cell.2007.02.023

    authors： Yoshimori T

    更新日期：2007-03-09 00:00:00

  • Stacked endoplasmic reticulum sheets are connected by helicoidal membrane motifs.

    abstract：:The endoplasmic reticulum (ER) often forms stacked membrane sheets, an arrangement that is likely required to accommodate a maximum of membrane-bound polysomes for secretory protein synthesis. How sheets are stacked is unknown. Here, we used improved staining and automated ultrathin sectioning electron microscopy meth...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2013.06.031

    authors： Terasaki M,Shemesh T,Kasthuri N,Klemm RW,Schalek R,Hayworth KJ,Hand AR,Yankova M,Huber G,Lichtman JW,Rapoport TA,Kozlov MM

    更新日期：2013-07-18 00:00:00

  • A Conserved Circular Network of Coregulated Lipids Modulates Innate Immune Responses.

    abstract：:Lipid composition affects the biophysical properties of membranes that provide a platform for receptor-mediated cellular signaling. To study the regulatory role of membrane lipid composition, we combined genetic perturbations of sphingolipid metabolism with the quantification of diverse steps in Toll-like receptor (TL...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2015.05.051

    authors： Köberlin MS,Snijder B,Heinz LX,Baumann CL,Fauster A,Vladimer GI,Gavin AC,Superti-Furga G

    更新日期：2015-07-02 00:00:00

  • A washable macromolecule from Fv2rr marrow negatively regulates DNA synthesis in erythropoietic progenitor cells BFU-E.

    abstract：:The proportion of BFU-E normally engaged in DNA synthesis is low in adult B6 (C57BL/6) mice of genotype Fv2rr (resistant to Friend erythroleukemia virus), as shown by 3H-thymidine or hydroxyurea "cell suicide" experiments in vivo and vitro. When bone marrow cells from these mice were subjected to a single wash in alph...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/0092-8674(81)90306-8

    authors： Axelrad AA,Croizat H,Eskinazi D

    更新日期：1981-10-01 00:00:00

  • The sequential action of miR156 and miR172 regulates developmental timing in Arabidopsis.

    abstract：:The transition from the juvenile to the adult phase of shoot development in plants is accompanied by changes in vegetative morphology and an increase in reproductive potential. Here, we describe the regulatory mechanism of this transition. We show that miR156 is necessary and sufficient for the expression of the juven...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2009.06.031

    authors： Wu G,Park MY,Conway SR,Wang JW,Weigel D,Poethig RS

    更新日期：2009-08-21 00:00:00

  • Three-dimensional structure of hepatitis B virus core particles determined by electron cryomicroscopy.

    abstract：:Human hepatitis B virus core protein expressed in E. coli assembles into two sizes of particle. We have determined their three-dimensional structures by electron cryomicroscopy and image processing. The large and small particles correspond to triangulation number T = 4 and T = 3 dimer clustered packings, containing 24...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/0092-8674(94)90142-2

    authors： Crowther RA,Kiselev NA,Böttcher B,Berriman JA,Borisova GP,Ose V,Pumpens P

    更新日期：1994-06-17 00:00:00

  • A major segment of the neurofibromatosis type 1 gene: cDNA sequence, genomic structure, and point mutations.

    abstract：:Overlapping cDNA clones from the translocation breakpoint region (TBR) gene, recently discovered at the neurofibromatosis type 1 locus and found to be interrupted by deletions and a t(17;22) translocation, have been sequenced. A 4 kb sequence of the transcript of the TBR gene has been compared with sequences of genomi...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/0092-8674(90)90253-b

    authors： Cawthon RM,Weiss R,Xu GF,Viskochil D,Culver M,Stevens J,Robertson M,Dunn D,Gesteland R,O'Connell P

    更新日期：1990-07-13 00:00:00