Connecting the dots between septins and the DNA damage checkpoint.

Abstract:

:In budding yeast, septins are involved in the morphogenesis checkpoint and the DNA damage checkpoint, both of which regulate cell-cycle progression. In this issue of Cell, Kremer et al. (2007) link septins to DNA damage in mammalian cells by identifying a new signaling pathway that includes the adaptors SOCS7 and NCK. As NCK controls actin dynamics, this pathway may connect DNA damage responses and cellular morphology in metazoans.

journal_name

Cell

journal_title

Cell

authors

Kinoshita M,Takeda S

doi

10.1016/j.cell.2007.08.022

subject

Has Abstract

pub_date

2007-09-07 00:00:00

pages

777-9

issue

5

eissn

0092-8674

issn

1097-4172

pii

S0092-8674(07)01085-9

journal_volume

130

pub_type

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