Epigenetic codes for heterochromatin formation and silencing: rounding up the usual suspects.

abstract：:Senescence in Podospora anserina has long been shown to be under cytoplasmic control. Comparison of DNAs isolated from young and senescent cultures made it possible to detect the presence, in senescent cultures only, of a specific DNA (SEN-DNA). This DNA consists of repeated sequences arranged in a multimeric set of c...

journal_title：Cell

authors： Jamet-Vierny C,Begel O,Belcour L

更新日期：1980-08-01 00:00:00

abstract：:The intestinal epithelium is a highly structured tissue composed of repeating crypt-villus units. Enterocytes perform the diverse tasks of absorbing a wide range of nutrients while protecting the body from the harsh bacterium-rich environment. It is unknown whether these tasks are spatially zonated along the villus ax...

journal_title：Cell

authors： Moor AE,Harnik Y,Ben-Moshe S,Massasa EE,Rozenberg M,Eilam R,Bahar Halpern K,Itzkovitz S

更新日期：2018-11-01 00:00:00

abstract：:A distinct subset of sensory neurons are thought to directly sense changes in thermal energy through their termini in the skin. Very little is known about the molecules that mediate thermoreception by these neurons. Vanilloid Receptor 1 (VR1), a member of the TRP family of channels, is activated by noxious heat. Here ...

journal_title：Cell

authors： Peier AM,Moqrich A,Hergarden AC,Reeve AJ,Andersson DA,Story GM,Earley TJ,Dragoni I,McIntyre P,Bevan S,Patapoutian A

更新日期：2002-03-08 00:00:00

abstract：:The subcellular distribution of the type II enzyme of cAMP-dependent protein kinase (cAMP-dPK II) in epithelial and fibroblastic cells was determined by indirect immunofluorescence microscopy. In interphase cells both regulatory (R II) and catalytic (C) subunits were concentrated in a perinuclear area. By comparison o...

journal_title：Cell

authors： Nigg EA,Schäfer G,Hilz H,Eppenberger HM

更新日期：1985-07-01 00:00:00

abstract：:The LIM domain protein rbtn2 is associated with T cell acute leukemias. We demonstrate that rbtn2 is a nuclear protein expressed in the erythroid lineage in vivo, and using homologous recombination, we show that it is essential for erythroid development in mice. The homozygous rbtn2 null mutation leads to failure of y...

journal_title：Cell

authors： Warren AJ,Colledge WH,Carlton MB,Evans MJ,Smith AJ,Rabbitts TH

更新日期：1994-07-15 00:00:00

abstract：:Inductive signals cause conversion of mesenchyme into epithelia during the formation of many organs. Yet a century of study has not revealed the inducing molecules. Using a standard model of induction, we found that ureteric bud cells secrete factors that convert kidney mesenchyme to epithelia that, remarkably, then f...

journal_title：Cell

authors： Barasch J,Yang J,Ware CB,Taga T,Yoshida K,Erdjument-Bromage H,Tempst P,Parravicini E,Malach S,Aranoff T,Oliver JA

更新日期：1999-11-12 00:00:00

abstract：:The actin-filled stereocilia of cochlear hair cells deflect in response to sound by pivoting around rootlets at their insertion points at the sensory cell surface. Kitajiri et al. (2010) now show that the actin-binding protein TRIOBP tightly bundles the actin filaments into rootlets, endowing these stereocilia "pivots...

journal_title：Cell

authors： Boutet de Monvel J,Petit C

更新日期：2010-05-28 00:00:00

abstract：:The GPA1 gene of S. cerevisiae encodes a G alpha subunit that plays a positive role in the transduction of signals stimulating recovery from pheromone-induced cell cycle arrest. The GPA1Val50 mutation, in which Gly-50 is replaced by valine, causes hyperadaptation to pheromone. However, GPA1Val50 cells do not recover f...

journal_title：Cell

authors： Irie K,Nomoto S,Miyajima I,Matsumoto K

更新日期：1991-05-31 00:00:00

abstract：:Activation of the adenylyl cyclase signaling pathway elicits the induction of genes via activators binding to cAMP-responsive elements (CREs). Nuclear factor CRE modulator (CREM) is activated by PKA-mediated phosphorylation on a serine at position 117. We show that Ser-117 is also phosphorylated by the mitogen-activat...

journal_title：Cell

authors： de Groot RP,Ballou LM,Sassone-Corsi P

更新日期：1994-10-07 00:00:00

abstract：:Loss of cell cycle control and acquisition of chromosomal rearrangements such as gene amplification often occur during tumor progression, suggesting that they may be correlated. We show here that the wild-type p53 allele is lost when fibroblasts from patients with the Li-Fraumeni syndrome (LFS) are passaged in vitro. ...

journal_title：Cell

authors： Yin Y,Tainsky MA,Bischoff FZ,Strong LC,Wahl GM

更新日期：1992-09-18 00:00:00

abstract：:Fractionation of a microsomal detergent extract with ammonium sulfate allows separation of the signal recognition particle receptor (SR alpha), which is required for targeting of the nascent chain, from other microsomal proteins, such as signal peptidase, whose activity is displayed during subsequent translocation. Th...

journal_title：Cell

authors： Nicchitta CV,Migliaccio G,Blobel G

更新日期：1991-05-17 00:00:00

abstract：:Replication of Escherichia coli plasmid p15A was examined by use of a cell extract or a mixture of three purified E. coli enzymes: RNA polymerase; RNAase H; and DNA polymerase I. In each system, replication initiates at any of three consecutive nucleotides located at a unique site. Primer transcription starts 508 bp u...

journal_title：Cell

authors： Selzer G,Som T,Itoh T,Tomizawa J

更新日期：1983-01-01 00:00:00

abstract：:We determined the nucleotide sequences of all coding regions and a significant part of the flanking regions of the chicken c-src gene, which is a cellular homolog of the v-src gene of Rous sarcoma virus. The c-src gene consists of 12 exons; the boundaries of the exons were determined by assuming that the amino acid se...

journal_title：Cell

authors： Takeya T,Hanafusa H

更新日期：1983-03-01 00:00:00

abstract：:Despite the obvious importance of epithelial stem cells in tissue homeostasis and tumorigenesis, little is known about their specific location or biological characteristics. Using 3H-thymidine labeling, we have identified a subpopulation of corneal epithelial basal cells, located in the peripheral cornea in a region c...

journal_title：Cell

authors： Cotsarelis G,Cheng SZ,Dong G,Sun TT,Lavker RM

更新日期：1989-04-21 00:00:00

abstract：:In Xenopus development, the expression of several maternal mRNAs is regulated by cytoplasmic polyadenylation. CPEB and maskin, two factors that control polyadenylation-induced translation are present on the mitotic apparatus of animal pole blastomeres in embryos. Cyclin B1 protein and mRNA, whose translation is regula...

journal_title：Cell

authors： Groisman I,Huang YS,Mendez R,Cao Q,Theurkauf W,Richter JD

更新日期：2000-10-27 00:00:00

abstract：:Telomerase activity was demonstrated in cell-free extracts from S. cerevisiae through the use of a PCR-based assay. As expected, this activity was eliminated by RNase or phenol treatment of the extract and was dependent on dGTP and dTTP. Telomerase was not detected in extracts prepared from cells grown for approximate...

journal_title：Cell

authors： Lin JJ,Zakian VA

更新日期：1995-06-30 00:00:00

abstract：:The Escherichia coli relBE operon encodes a toxin-antitoxin pair, RelE-RelB. RelB can reverse inhibition of protein synthesis by RelE in vivo. We have found that although RelE does not degrade free RNA, it cleaves mRNA in the ribosomal A site with high codon specificity. Among stop codons UAG is cleaved with fast, UAA...

journal_title：Cell

authors： Pedersen K,Zavialov AV,Pavlov MY,Elf J,Gerdes K,Ehrenberg M

更新日期：2003-01-10 00:00:00

abstract：:In many cases the multiple genes coding for one specific tRNA are dispersed throughout the genome. The members of such a gene family nevertheless maintain a common nucleotide sequence during evolution. A major mechanism contributing to this concerted evolution is intergenic conversion. Here we show that it occurs betw...

journal_title：Cell

authors： Amstutz H,Munz P,Heyer WD,Leupoid U,Kohli J

更新日期：1985-04-01 00:00:00

abstract：:Three recent papers reveal a fascinating link between pol II termination and ribonucleolytic decay of the nascent transcript by a 5'-3' exonuclease (yeast Rat1 and human Xrn2). The exonuclease travels with pol II and gains access to the nascent RNA after endonucleolytic cleavage at the poly(A) site or at a second cotr...

journal_title：Cell

authors： Luo W,Bentley D

更新日期：2004-12-29 00:00:00

abstract：:Aging has been associated with a progressive decline of proteostasis, but how this process affects proteome composition remains largely unexplored. Here, we profiled more than 5,000 proteins along the lifespan of the nematode C. elegans. We find that one-third of proteins change in abundance at least 2-fold during agi...

journal_title：Cell

authors： Walther DM,Kasturi P,Zheng M,Pinkert S,Vecchi G,Ciryam P,Morimoto RI,Dobson CM,Vendruscolo M,Mann M,Hartl FU

更新日期：2015-05-07 00:00:00

abstract：:The role of the noncoding genome in cancer biology is continually expanding. Cho et al. reveal a new and unexpected mechanism for the regulation of MYC expression mediated by the promoter sequence of its neighbor gene PVT1. This DNA element acts as a promoter-enhancer competitor and a candidate tumor suppressor. ...

journal_title：Cell

authors： Marchese FP,Huarte M

更新日期：2018-05-31 00:00:00

abstract：:We previously demonstrated that pseudogenes complementary to the small nuclear RNAs U1, U2 and U3 are dispersed and abundant in the human genome. Here we report that three pseudogenes (U1.101, U2.13 and U3.5) are flanked by perfect short direct repeats of 16 to 19 base pairs. In all three pseudogenes. the upstream dir...

journal_title：Cell

authors： Van Arsdell SW,Denison RA,Bernstein LB,Weiner AM,Manser T,Gesteland RF

更新日期：1981-10-01 00:00:00

abstract：:We studied the chromatin structure and methylation of ribosomal RNA genes (rDNA) in hybrids between Xenopus laevis and Xenopus borealis. S1-nuclease protection experiments showed that 97%-98% of the rRNA precursor in hybrid tadpoles was of the X. laevis type. Preferential expression of the laevis rDNA was correlated w...

journal_title：Cell

authors： Macleod D,Bird A

更新日期：1982-05-01 00:00:00

abstract：:Targeted gene regulation on a genome-wide scale is a powerful strategy for interrogating, perturbing, and engineering cellular systems. Here, we develop a method for controlling gene expression based on Cas9, an RNA-guided DNA endonuclease from a type II CRISPR system. We show that a catalytically dead Cas9 lacking en...

journal_title：Cell

authors： Qi LS,Larson MH,Gilbert LA,Doudna JA,Weissman JS,Arkin AP,Lim WA

更新日期：2013-02-28 00:00:00

abstract：:Type 2 diabetes (T2D) is a worldwide epidemic with a medical need for additional targeted therapies. Suppression of hepatic glucose production (HGP) effectively ameliorates diabetes and can be exploited for its treatment. We hypothesized that targeting PGC-1α acetylation in the liver, a chemical modification known to ...

journal_title：Cell

authors： Sharabi K,Lin H,Tavares CDJ,Dominy JE,Camporez JP,Perry RJ,Schilling R,Rines AK,Lee J,Hickey M,Bennion M,Palmer M,Nag PP,Bittker JA,Perez J,Jedrychowski MP,Ozcan U,Gygi SP,Kamenecka TM,Shulman GI,Schreiber SL,Gr

更新日期：2017-03-23 00:00:00

abstract：:Metabolic coordination between neurons and astrocytes is critical for the health of the brain. However, neuron-astrocyte coupling of lipid metabolism, particularly in response to neural activity, remains largely uncharacterized. Here, we demonstrate that toxic fatty acids (FAs) produced in hyperactive neurons are tran...

journal_title：Cell

authors： Ioannou MS,Jackson J,Sheu SH,Chang CL,Weigel AV,Liu H,Pasolli HA,Xu CS,Pang S,Matthies D,Hess HF,Lippincott-Schwartz J,Liu Z

更新日期：2019-05-30 00:00:00

abstract：:Inhibitor of apoptosis proteins (IAPs) such as XIAP, cIAP1, and cIAP2 are upregulated in many cancer cells. It has been thought that small-molecule mimetics of Smac, an endogenous IAP antagonist, might potentiate apoptosis in cancer cells by promoting caspase activation. However, three recent papers, two in Cell (Vinc...

journal_title：Cell

authors： Wu H,Tschopp J,Lin SC

更新日期：2007-11-16 00:00:00

abstract：:A key feature of plants (as opposed to animals) is their ability to establish new organs not only during embryogenesis, but also throughout their development. A master regulator of organ initiation in plants is the phytohormone auxin. Auxin acts locally as a morphogen and is directionally transported from cell to cell...

journal_title：Cell

authors： Jaillais Y,Santambrogio M,Rozier F,Fobis-Loisy I,Miège C,Gaude T

更新日期：2007-09-21 00:00:00

abstract：:Lineage tracing is the identification of all progeny of a single cell. Although its origins date back to developmental biology of invertebrates in the 19(th) century, lineage tracing is now an essential tool for studying stem cell properties in adult mammalian tissues. Lineage tracing provides a powerful means of unde...

journal_title：Cell

authors： Kretzschmar K,Watt FM

更新日期：2012-01-20 00:00:00

abstract：:V(D)J recombination of antigen receptor gene segments in B and T cells is mediated by the lymphoid-specific proteins RAG1 and RAG2. Now, Ji et al. (2010) demonstrate how RAG1 and RAG2 use DNA sequence specificity and modified histones within chromatin to target specific loci for V(D)J recombination at different stages...

journal_title：Cell

authors： Schlissel MS

更新日期：2010-04-30 00:00:00