Sequence organization of a cloned tDNA met fragment from Xenopus laevis.

abstract：:A comprehensive analysis uncovered a set of yeast proteins promoting protein-based inheritance that shares many of the non-Mendelian properties of prions. Lacking any sequence or structural signatures of known prions, these proteins represent a new class of non-amyloid, protein-based epigenetic determinants that can c...

journal_title：Cell

authors： Tuite MF

更新日期：2016-10-06 00:00:00

abstract：:Activation of Agouti-related peptide (AgRP) neurons potently promotes feeding, and chronically altering their activity also affects peripheral glucose homeostasis. We demonstrate that acute activation of AgRP neurons causes insulin resistance through impairment of insulin-stimulated glucose uptake into brown adipose t...

journal_title：Cell

authors： Steculorum SM,Ruud J,Karakasilioti I,Backes H,Engström Ruud L,Timper K,Hess ME,Tsaousidou E,Mauer J,Vogt MC,Paeger L,Bremser S,Klein AC,Morgan DA,Frommolt P,Brinkkötter PT,Hammerschmidt P,Benzing T,Rahmouni K,Wunder

更新日期：2016-03-24 00:00:00

abstract：:ABCA1, an ATP-binding cassette (ABC) subfamily A exporter, mediates the cellular efflux of phospholipids and cholesterol to the extracellular acceptor apolipoprotein A-I (apoA-I) for generation of nascent high-density lipoprotein (HDL). Mutations of human ABCA1 are associated with Tangier disease and familial HDL defi...

journal_title：Cell

authors： Qian H,Zhao X,Cao P,Lei J,Yan N,Gong X

更新日期：2017-06-15 00:00:00

abstract：:Two cDNAs were isolated whose dimerized products bind specifically to a DNA sequence, kappa E2, located in the immunoglobulin kappa chain enhancer. Both cDNAs share a region of extensive identity to the Drosophila daughterless gene and obvious similarity to a segment in three myc proteins, MyoD, and members of the Dro...

journal_title：Cell

authors： Murre C,McCaw PS,Baltimore D

更新日期：1989-03-10 00:00:00

abstract：:Herpes simplex virus type 1 (HSV-1) binds to cells through interactions of viral glycoproteins gB and gC with heparan sulfate chains on cell surface proteoglycans. This binding is not sufficient for viral entry, which requires fusion between the viral envelope and cell membrane. Here, we show that heparan sulfate modi...

journal_title：Cell

authors： Shukla D,Liu J,Blaiklock P,Shworak NW,Bai X,Esko JD,Cohen GH,Eisenberg RJ,Rosenberg RD,Spear PG

更新日期：1999-10-01 00:00:00

abstract：:Goosecoid (gsc), a homeobox gene expressed specifically in the dorsal blastopore lip of the Xenopus gastrula, is considered to play an important role in Spemann's organizer phenomenon. Lineage tracing and time-lapse microscopy were used to follow the fate of embryonic cells microinjected with gsc mRNA. Microinjected g...

journal_title：Cell

authors： Niehrs C,Keller R,Cho KW,De Robertis EM

更新日期：1993-02-26 00:00:00

abstract：:Bacteria are known to communicate primarily via secreted extracellular factors. Here we identify a previously uncharacterized type of bacterial communication mediated by nanotubes that bridge neighboring cells. Using Bacillus subtilis as a model organism, we visualized transfer of cytoplasmic fluorescent molecules bet...

journal_title：Cell

authors： Dubey GP,Ben-Yehuda S

更新日期：2011-02-18 00:00:00

abstract：:We have isolated a dominant mutation in a gene called Son of sevenless (Sos) that is an allele-specific suppressor of the sevenless phenotype. This suppressor function is autonomously required in R7 and is sensitive to the dosage of the Sos and bride of sevenless genes. Loss-of-function alleles of Sos are recessive le...

journal_title：Cell

authors： Rogge RD,Karlovich CA,Banerjee U

更新日期：1991-01-11 00:00:00

abstract：:Autophagy (literally self-eating) has diverse cytoprotective functions but also is linked to programmed cell death (PCD). In this issue, Qu et al. (2007) analyze the role of autophagy in PCD during development. Unexpectedly they find that autophagy induces apoptotic cells to present a signal to ensure their clearance,...

journal_title：Cell

authors： Yoshimori T

更新日期：2007-03-09 00:00:00

abstract：:Metabolic coordination between neurons and astrocytes is critical for the health of the brain. However, neuron-astrocyte coupling of lipid metabolism, particularly in response to neural activity, remains largely uncharacterized. Here, we demonstrate that toxic fatty acids (FAs) produced in hyperactive neurons are tran...

journal_title：Cell

authors： Ioannou MS,Jackson J,Sheu SH,Chang CL,Weigel AV,Liu H,Pasolli HA,Xu CS,Pang S,Matthies D,Hess HF,Lippincott-Schwartz J,Liu Z

更新日期：2019-05-30 00:00:00

abstract：:IFN-γ-activated macrophages attempt to limit pathogen growth through tryptophan starvation. Zhang et al. demonstrate that Mycobacterium tuberculosis responds to this threat by synthesizing its own tryptophan. Genetic and chemical inhibition of this pathway reduces mycobacterial survival, revealing a new immune-depende...

journal_title：Cell

authors： Russell DG

更新日期：2013-12-05 00:00:00

abstract：:The pathway of RNA polymerase entry at the lac promoter was studied by investigating the relationship between the promoter and a weak, overlapping polymerase interaction site (P2). If polymerase is made to enter the DNA by binding in vitro at this P2 site, cyclic AMP receptor protein (CRP) actively removes polymerase ...

journal_title：Cell

authors： Meiklejohn AL,Gralla JD

更新日期：1985-12-01 00:00:00

abstract：:The posttranslational modification of proteins by methylglyoxal, a highly reactive compound derived from glycolysis, may contribute to aging, diabetes, and other disorders. In this issue of Cell, Brownlee and colleagues (Yao et al., 2006) demonstrate a specific mechanism by which methylglyoxal modifies a transcription...

journal_title：Cell

authors： Ramasamy R,Yan SF,Schmidt AM

更新日期：2006-01-27 00:00:00

abstract：:The structure of chicken erythrocyte and chicken liver chromatin has been studied by enzymatic digestion with micrococcal nuclease and DNAase I. Comparison of the fragments produced by brief digestion with micrococcal nuclease indicates that chicken erythrocyte chromatin has a longer nucleosome repeat than chicken liv...

journal_title：Cell

authors： Morris NR

更新日期：1976-12-01 00:00:00

abstract：:The mammalian BAF complex regulates gene expression by modifying chromatin structure. In this report, we identify 80 genes activated and 2 genes repressed by the BAF complex in SW-13 cells. We find that prior binding of NFI/CTF to the NFI/CTF binding site in CSF1 promoter is required for the recruitment of the BAF com...

journal_title：Cell

authors： Liu R,Liu H,Chen X,Kirby M,Brown PO,Zhao K

更新日期：2001-08-10 00:00:00

abstract：:Transcriptional regulation in the galactose regulon of yeast is determined by an interplay between a positive regulatory protein, GAL4, and a negative regulatory protein, GAL80. We show that derivatives of GAL4 missing as few as 28 carboxy-terminal amino acids are not responsive to GAL80 regulation, implying that the ...

journal_title：Cell

authors： Johnston SA,Salmeron JM Jr,Dincher SS

更新日期：1987-07-03 00:00:00

abstract：:The transcription factor NRF2 is a master regulator of the cellular antioxidant response, and it is often genetically activated in non-small-cell lung cancers (NSCLCs) by, for instance, mutations in the negative regulator KEAP1. While direct pharmacological inhibition of NRF2 has proven challenging, its aberrant activ...

journal_title：Cell

authors： Bar-Peled L,Kemper EK,Suciu RM,Vinogradova EV,Backus KM,Horning BD,Paul TA,Ichu TA,Svensson RU,Olucha J,Chang MW,Kok BP,Zhu Z,Ihle NT,Dix MM,Jiang P,Hayward MM,Saez E,Shaw RJ,Cravatt BF

更新日期：2017-10-19 00:00:00

abstract：:Four major receptor families enable cells to respond to chemical and physical signals from their proximal environment. The ligand- and voltage-gated ion channels, G-protein-coupled receptors, nuclear hormone receptors, and receptor tyrosine kinases are all allosteric proteins that carry multiple, spatially distinct, y...

journal_title：Cell

authors： Changeux JP,Christopoulos A

更新日期：2016-08-25 00:00:00

abstract：:Trigger factor (TF) is a molecular chaperone that binds to bacterial ribosomes where it contacts emerging nascent chains, but TF is also abundant free in the cytosol where its activity is less well characterized. In vitro studies show that TF promotes protein refolding. We find here that ribosome-free TF stably associ...

journal_title：Cell

authors： Martinez-Hackert E,Hendrickson WA

更新日期：2009-09-04 00:00:00

abstract：:A 57 kd component of oligosaccharyl transferase, termed glycosylation site binding protein, specifically recognizes a photoaffinity probe containing the N-glycosylation site sequence Asn-Lys-Thr. It is present in the lumen of the ER (endoplasmic reticulum) and its release from this compartment results in a loss of N-g...

journal_title：Cell

authors： Geetha-Habib M,Noiva R,Kaplan HA,Lennarz WJ

更新日期：1988-09-23 00:00:00

abstract：:Sharply delineated domains of cell types arise in developing tissues under instruction of inductive signal (morphogen) gradients, which specify distinct cell fates at different signal levels. The translation of a morphogen gradient into discrete spatial domains relies on precise signal responses at stable cell positio...

journal_title：Cell

authors： Xiong F,Tentner AR,Huang P,Gelas A,Mosaliganti KR,Souhait L,Rannou N,Swinburne IA,Obholzer ND,Cowgill PD,Schier AF,Megason SG

更新日期：2013-04-25 00:00:00

abstract：:Social isolation is a stressful condition that often leads to maladaptive behaviors. In this issue of Cell, Zelikowsky et al. find that chronic social isolation stress triggers an increase in neuronal tachykinin signaling across distinct brain regions that mediate fear and aggression, elucidating the neural basis of t...

journal_title：Cell

authors： Rodriguez-Romaguera J,Stuber GD

更新日期：2018-05-17 00:00:00

abstract：:Nucleotide sequences in two wild-type and six mutant operators in the DNA of phage lambda are compared. Strikingly similar 17 base pair units are found which we identify as the repressor binding sites. Each operator contains multiple repressor binding sites separated by A-T rich spacers. Elements of 2 fold rotational ...

journal_title：Cell

authors： Maniatis T,Ptashne M,Backman K,Kield D,Flashman S,Jeffrey A,Maurer R

更新日期：1975-06-01 00:00:00

abstract：:p25rum1 from the fission yeast S. pombe is shown to act as a specific in vitro inhibitor of the p34cdc2/p56cdc13 mitotic kinase. It is also shown that early G1 cells contain p25rum1, which associates with and inhibits the mitotic kinase, and maintains p56cdc13 mitotic B cyclin at a low level, ensuring that these cells...

journal_title：Cell

authors： Correa-Bordes J,Nurse P

更新日期：1995-12-15 00:00:00

abstract：:Developing cells of the cellular slime mold Dictyostelium discoideum release a low molecular weight metabolite (Slug Turning Factor, STF) which, at high uniform concentrations, interferes with phototaxis and thermotaxis by D. discoideum slugs. D. discoideum slugs migrating in darkness are repelled by (exhibit negative...

journal_title：Cell

authors： Fisher PR,Smith E,Williams KL

更新日期：1981-03-01 00:00:00

abstract：:The tumor suppressor p53 exerts antiproliferation effects through its ability to function as a sequence-specific DNA-binding transcription factor. Here, we demonstrate that p53 can be modified by acetylation both in vivo and in vitro. Remarkably, the site of p53 that is acetylated by its coactivator, p300, resides in ...

journal_title：Cell

authors： Gu W,Roeder RG

更新日期：1997-08-22 00:00:00

abstract：:Four RNA products have been characterized from a soluble system that accurately splices purified substrate RNA. The labeled substrate RNA contained the first and second exons of the major late transcription unit of adenovirus 2 and a shortened form of the first intervening sequence. One of these RNA products was the e...

journal_title：Cell

authors： Grabowski PJ,Padgett RA,Sharp PA

更新日期：1984-06-01 00:00:00

abstract：:Organ cultures of liver from untreated male Xenopus respond to 17 beta-estradiol in the culture medium by synthesizing and secreting the yolk protein precursor vitellogenin. Vitellogenin synthesis, as a primary response, is first detectable on the fourth day of culture, and comprises up to 12% of the protein synthesiz...

journal_title：Cell

authors： Green CD,Tata JR

更新日期：1976-01-01 00:00:00

abstract：:We have studied the interaction of highly purified Int protein with DNA restriction fragments from the lambda phage attachment site (attP) region. Two different DNA sequences are protected by bound Int protein against partial digestion by either pancreatic DNAase or neocarzinostatin. One Int binding site includes the ...

journal_title：Cell

authors： Ross W,Landy A,Kikuchi Y,Nash H

更新日期：1979-10-01 00:00:00

abstract：:E-cadherin is a major homophilic cell-cell adhesion molecule that inhibits motility of individual cells on matrix. However, its contribution to migration of cells through cell-rich tissues is less clear. We developed an in vivo sensor of mechanical tension across E-cadherin molecules, which we combined with cell-type-...

journal_title：Cell

authors： Cai D,Chen SC,Prasad M,He L,Wang X,Choesmel-Cadamuro V,Sawyer JK,Danuser G,Montell DJ

更新日期：2014-05-22 00:00:00