当前位置： SCI文献检索 > CELL期刊下所有文献 > Mechanical feedback through E-cadherin promotes direction sensing during collective cell migration.

Mechanical feedback through E-cadherin promotes direction sensing during collective cell migration.

Abstract：

:E-cadherin is a major homophilic cell-cell adhesion molecule that inhibits motility of individual cells on matrix. However, its contribution to migration of cells through cell-rich tissues is less clear. We developed an in vivo sensor of mechanical tension across E-cadherin molecules, which we combined with cell-type-specific RNAi, photoactivatable Rac, and morphodynamic profiling, to interrogate how E-cadherin contributes to collective migration of cells between other cells. Using the Drosophila ovary as a model, we found that adhesion between border cells and their substrate, the nurse cells, functions in a positive feedback loop with Rac and actin assembly to stabilize forward-directed protrusion and directionally persistent movement. Adhesion between individual border cells communicates direction from the lead cell to the followers. Adhesion between motile cells and polar cells holds the cluster together and polarizes each individual cell. Thus, E-cadherin is an integral component of the guidance mechanisms that orchestrate collective chemotaxis in vivo.

journal_name

Cell

journal_title

Cell

authors

Cai D,Chen SC,Prasad M,He L,Wang X,Choesmel-Cadamuro V,Sawyer JK,Danuser G,Montell DJ

doi

10.1016/j.cell.2014.03.045

subject

Has Abstract

pub_date

2014-05-22 00:00:00

pages

1146-59

issue

5

eissn

0092-8674

issn

1097-4172

pii

S0092-8674(14)00473-5

journal_volume

157

pub_type

杂志文章

相关文献

CELL文献大全
  • Linking RNA polymerase backtracking to genome instability in E. coli.

    abstract：:Frequent codirectional collisions between the replisome and RNA polymerase (RNAP) are inevitable because the rate of replication is much faster than that of transcription. Here we show that, in E. coli, the outcome of such collisions depends on the productive state of transcription elongation complexes (ECs). Codirect...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2011.07.034

    authors： Dutta D,Shatalin K,Epshtein V,Gottesman ME,Nudler E

    更新日期：2011-08-19 00:00:00

  • The transcriptional and epigenomic foundations of ground state pluripotency.

    abstract：:Mouse embryonic stem (ES) cells grown in serum exhibit greater heterogeneity in morphology and expression of pluripotency factors than ES cells cultured in defined medium with inhibitors of two kinases (Mek and GSK3), a condition known as "2i" postulated to establish a naive ground state. We show that the transcriptom...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2012.03.026

    authors： Marks H,Kalkan T,Menafra R,Denissov S,Jones K,Hofemeister H,Nichols J,Kranz A,Stewart AF,Smith A,Stunnenberg HG

    更新日期：2012-04-27 00:00:00

  • Embryonic stem cell self-renewal, analyzed.

    abstract：:Maintaining the pluripotency of mouse ES cells requires both LIF (leukemia inhibitory factor) and unknown factors in serum. The paper from Ying et al. in this issue of Cell shows that BMP (bone morphogenetic protein) can replace serum in this capacity, defining molecular requirements for ES cell self-renewal. ...

    journal_title：Cell

    pub_type： 评论,杂志文章

    doi：10.1016/s0092-8674(03)00853-5

    authors： Temple S

    更新日期：2003-10-31 00:00:00

  • A Novel Class of ER Membrane Proteins Regulates ER-Associated Endosome Fission.

    abstract：:Endoplasmic reticulum (ER) membrane contact sites (MCSs) mark positions where endosomes undergo fission for cargo sorting. To define the role of ER at this unique MCS, we targeted a promiscuous biotin ligase to cargo-sorting domains on endosome buds. This strategy identified the ER membrane protein TMCC1, a member of ...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2018.08.030

    authors： Hoyer MJ,Chitwood PJ,Ebmeier CC,Striepen JF,Qi RZ,Old WM,Voeltz GK

    更新日期：2018-09-20 00:00:00

  • Adrenergic Signaling in Muscularis Macrophages Limits Infection-Induced Neuronal Loss.

    abstract：:Enteric-associated neurons (EANs) are closely associated with immune cells and continuously monitor and modulate homeostatic intestinal functions, including motility and nutrient sensing. Bidirectional interactions between neuronal and immune cells are altered during disease processes such as neurodegeneration or irri...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2019.12.002

    authors： Matheis F,Muller PA,Graves CL,Gabanyi I,Kerner ZJ,Costa-Borges D,Ahrends T,Rosenstiel P,Mucida D

    更新日期：2020-01-09 00:00:00

  • Two enzymes in one; two yeast peroxiredoxins display oxidative stress-dependent switching from a peroxidase to a molecular chaperone function.

    abstract：:Although a great deal is known biochemically about peroxiredoxins (Prxs), little is known about their real physiological function. We show here that two cytosolic yeast Prxs, cPrxI and II, which display diversity in structure and apparent molecular weights (MW), can act alternatively as peroxidases and molecular chape...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2004.05.002

    authors： Jang HH,Lee KO,Chi YH,Jung BG,Park SK,Park JH,Lee JR,Lee SS,Moon JC,Yun JW,Choi YO,Kim WY,Kang JS,Cheong GW,Yun DJ,Rhee SG,Cho MJ,Lee SY

    更新日期：2004-05-28 00:00:00

  • Sites of topoisomerase I action on X. laevis ribosomal chromatin: transcriptionally active rDNA has an approximately 200 bp repeating structure.

    abstract：:The sites at which topoisomerase I interacts with the transcriptionally active ribosomal chromatin of Xenopus oocytes were mapped by treating oocyte nuclei first with camptothecin to stabilize topoisomerase I-rDNA reaction intermediates, and then with SDS to resolve these adducts as protein-linked nicks in the DNA. St...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/0092-8674(88)90471-0

    authors： Culotta V,Sollner-Webb B

    更新日期：1988-02-26 00:00:00

  • Mesenchymal to epithelial conversion in rat metanephros is induced by LIF.

    abstract：:Inductive signals cause conversion of mesenchyme into epithelia during the formation of many organs. Yet a century of study has not revealed the inducing molecules. Using a standard model of induction, we found that ureteric bud cells secrete factors that convert kidney mesenchyme to epithelia that, remarkably, then f...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/s0092-8674(00)81524-x

    authors： Barasch J,Yang J,Ware CB,Taga T,Yoshida K,Erdjument-Bromage H,Tempst P,Parravicini E,Malach S,Aranoff T,Oliver JA

    更新日期：1999-11-12 00:00:00

  • A homeodomain protein code specifies progenitor cell identity and neuronal fate in the ventral neural tube.

    abstract：:Distinct classes of neurons are generated at defined positions in the ventral neural tube in response to a gradient of Sonic Hedgehog (Shh) activity. A set of homeodomain transcription factors expressed by neural progenitors act as intermediaries in Shh-dependent neural patterning. These homeodomain factors fall into ...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/s0092-8674(00)80853-3

    authors： Briscoe J,Pierani A,Jessell TM,Ericson J

    更新日期：2000-05-12 00:00:00

  • Structural and Mechanistic Basis of PAM-Dependent Spacer Acquisition in CRISPR-Cas Systems.

    abstract：:Bacteria acquire memory of viral invaders by incorporating invasive DNA sequence elements into the host CRISPR locus, generating a new spacer within the CRISPR array. We report on the structures of Cas1-Cas2-dual-forked DNA complexes in an effort toward understanding how the protospacer is sampled prior to insertion i...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2015.10.008

    authors： Wang J,Li J,Zhao H,Sheng G,Wang M,Yin M,Wang Y

    更新日期：2015-11-05 00:00:00

  • Munc13-4 is essential for cytolytic granules fusion and is mutated in a form of familial hemophagocytic lymphohistiocytosis (FHL3).

    abstract：:Secretion of cytolytic granules content at the immunological synapse is a highly regulated process essential for lymphocyte cytotoxicity. This process requires the rapid transfer of perforin containing lytic granules to the target cell interface, followed by their docking and fusion with the plasma membrane. Defective...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/s0092-8674(03)00855-9

    authors： Feldmann J,Callebaut I,Raposo G,Certain S,Bacq D,Dumont C,Lambert N,Ouachée-Chardin M,Chedeville G,Tamary H,Minard-Colin V,Vilmer E,Blanche S,Le Deist F,Fischer A,de Saint Basile G

    更新日期：2003-11-14 00:00:00

  • NF-κB c-Rel Is Crucial for the Regulatory T Cell Immune Checkpoint in Cancer.

    abstract：:Regulatory T cells (Tregs) play a pivotal role in the inhibition of anti-tumor immune responses. Understanding the mechanisms governing Treg homeostasis may therefore be important for development of effective tumor immunotherapy. We have recently demonstrated a key role for the canonical nuclear factor κB (NF-κB) subu...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2017.08.004

    authors： Grinberg-Bleyer Y,Oh H,Desrichard A,Bhatt DM,Caron R,Chan TA,Schmid RM,Klein U,Hayden MS,Ghosh S

    更新日期：2017-09-07 00:00:00

  • Tumor promoter-induced changes in the permeability of epithelial cell tight junctions.

    abstract：:Treatment of the kidney epithelial cell line MDCK with the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) induces a large increase in the permeability of tight junctions within 2-4 hr. This change in transepithelial permeability is accompanied by alterations in cell morphology that include the opening of ti...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/0092-8674(81)90274-9

    authors： Ojakian GK

    更新日期：1981-01-01 00:00:00

  • Oncogenic Signaling Pathways in The Cancer Genome Atlas.

    abstract：:Genetic alterations in signaling pathways that control cell-cycle progression, apoptosis, and cell growth are common hallmarks of cancer, but the extent, mechanisms, and co-occurrence of alterations in these pathways differ between individual tumors and tumor types. Using mutations, copy-number changes, mRNA expressio...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2018.03.035

    authors： Sanchez-Vega F,Mina M,Armenia J,Chatila WK,Luna A,La KC,Dimitriadoy S,Liu DL,Kantheti HS,Saghafinia S,Chakravarty D,Daian F,Gao Q,Bailey MH,Liang WW,Foltz SM,Shmulevich I,Ding L,Heins Z,Ochoa A,Gross B,Gao J,Z

    更新日期：2018-04-05 00:00:00

  • RETRACTED: Crystal structure of a complement control protein that regulates both pathways of complement activation and binds heparan sulfate proteoglycans.

    abstract：:This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). This article has been retracted at the request of request of the editors. Cell is retracting this paper reporting structures of a poxvirus protein, VCP, that inhi...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/s0092-8674(01)00214-8

    authors： Murthy KH,Smith SA,Ganesh VK,Judge KW,Mullin N,Barlow PN,Ogata CM,Kotwal GJ

    更新日期：2001-01-26 00:00:00

  • Modeling Rett syndrome with stem cells.

    abstract：:The discovery that somatic cells can be reprogrammed into induced pluripotent stem cells (iPSCs) raised the exciting possibility of modeling diseases with patient-specific cells. Marchetto et al. (2010) now use iPSC technology to generate, characterize, and treat an in vitro model for the autism spectrum disorder Rett...

    journal_title：Cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.cell.2010.10.037

    authors： Walsh RM,Hochedlinger K

    更新日期：2010-11-12 00:00:00

  • Rickettsia Sca4 Reduces Vinculin-Mediated Intercellular Tension to Promote Spread.

    abstract：:Spotted fever group (SFG) rickettsiae are human pathogens that infect cells in the vasculature. They disseminate through host tissues by a process of cell-to-cell spread that involves protrusion formation, engulfment, and vacuolar escape. Other bacterial pathogens rely on actin-based motility to provide a physical for...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2016.09.023

    authors： Lamason RL,Bastounis E,Kafai NM,Serrano R,Del Álamo JC,Theriot JA,Welch MD

    更新日期：2016-10-20 00:00:00

  • Cryo-EM Structure of the Human Cannabinoid Receptor CB2-Gi Signaling Complex.

    abstract：:Drugs selectively targeting CB2 hold promise for treating neurodegenerative disorders, inflammation, and pain while avoiding psychotropic side effects mediated by CB1. The mechanisms underlying CB2 activation and signaling are poorly understood but critical for drug design. Here we report the cryo-EM structure of the ...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2020.01.007

    authors： Xing C,Zhuang Y,Xu TH,Feng Z,Zhou XE,Chen M,Wang L,Meng X,Xue Y,Wang J,Liu H,McGuire TF,Zhao G,Melcher K,Zhang C,Xu HE,Xie XQ

    更新日期：2020-02-20 00:00:00

  • A human protein-protein interaction network: a resource for annotating the proteome.

    abstract：:Protein-protein interaction maps provide a valuable framework for a better understanding of the functional organization of the proteome. To detect interacting pairs of human proteins systematically, a protein matrix of 4456 baits and 5632 preys was screened by automated yeast two-hybrid (Y2H) interaction mating. We id...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2005.08.029

    authors： Stelzl U,Worm U,Lalowski M,Haenig C,Brembeck FH,Goehler H,Stroedicke M,Zenkner M,Schoenherr A,Koeppen S,Timm J,Mintzlaff S,Abraham C,Bock N,Kietzmann S,Goedde A,Toksöz E,Droege A,Krobitsch S,Korn B,Birchmeier W,

    更新日期：2005-09-23 00:00:00

  • The Striatum Organizes 3D Behavior via Moment-to-Moment Action Selection.

    abstract：:Many naturalistic behaviors are built from modular components that are expressed sequentially. Although striatal circuits have been implicated in action selection and implementation, the neural mechanisms that compose behavior in unrestrained animals are not well understood. Here, we record bulk and cellular neural ac...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2018.04.019

    authors： Markowitz JE,Gillis WF,Beron CC,Neufeld SQ,Robertson K,Bhagat ND,Peterson RE,Peterson E,Hyun M,Linderman SW,Sabatini BL,Datta SR

    更新日期：2018-06-28 00:00:00

  • LIMP-2 is a receptor for lysosomal mannose-6-phosphate-independent targeting of beta-glucocerebrosidase.

    abstract：:beta-glucocerebrosidase, the enzyme defective in Gaucher disease, is targeted to the lysosome independently of the mannose-6-phosphate receptor. Affinity-chromatography experiments revealed that the lysosomal integral membrane protein LIMP-2 is a specific binding partner of beta-glucocerebrosidase. This interaction in...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2007.10.018

    authors： Reczek D,Schwake M,Schröder J,Hughes H,Blanz J,Jin X,Brondyk W,Van Patten S,Edmunds T,Saftig P

    更新日期：2007-11-16 00:00:00

  • Structure and sequence of the cellular gene homologous to the RSV src gene and the mechanism for generating the transforming virus.

    abstract：:We determined the nucleotide sequences of all coding regions and a significant part of the flanking regions of the chicken c-src gene, which is a cellular homolog of the v-src gene of Rous sarcoma virus. The c-src gene consists of 12 exons; the boundaries of the exons were determined by assuming that the amino acid se...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/0092-8674(83)90073-9

    authors： Takeya T,Hanafusa H

    更新日期：1983-03-01 00:00:00

  • The winged-helix transcription factor HNF-3 beta is required for notochord development in the mouse embryo.

    abstract：:HNF-3 beta, a transcription factor of the winged-helix family, is expressed in embryonic and adult endoderm and also in midline cells of the node, notochord, and floor plate in mouse embryos. To define the function of HNF-3 beta, a targeted mutation in the HNF-3 beta locus was generated by homologous recombination in ...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/0092-8674(94)90523-1

    authors： Weinstein DC,Ruiz i Altaba A,Chen WS,Hoodless P,Prezioso VR,Jessell TM,Darnell JE Jr

    更新日期：1994-08-26 00:00:00

  • Rumi is a CAP10 domain glycosyltransferase that modifies Notch and is required for Notch signaling.

    abstract：:Notch signaling is broadly used to regulate cell-fate decisions. We have identified a gene, rumi, with a temperature-sensitive Notch phenotype. At 28 degrees C-30 degrees C, rumi clones exhibit a full-blown loss of Notch signaling in all tissues tested. However, at 18 degrees C only a mild Notch phenotype is evident. ...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2007.12.016

    authors： Acar M,Jafar-Nejad H,Takeuchi H,Rajan A,Ibrani D,Rana NA,Pan H,Haltiwanger RS,Bellen HJ

    更新日期：2008-01-25 00:00:00

  • Chromatin fibers are formed by heterogeneous groups of nucleosomes in vivo.

    abstract：:Nucleosomes help structure chromosomes by compacting DNA into fibers. To gain insight into how nucleosomes are arranged in vivo, we combined quantitative super-resolution nanoscopy with computer simulations to visualize and count nucleosomes along the chromatin fiber in single nuclei. Nucleosomes assembled in heteroge...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/j.cell.2015.01.054

    authors： Ricci MA,Manzo C,García-Parajo MF,Lakadamyali M,Cosma MP

    更新日期：2015-03-12 00:00:00

  • Meiotic recombination in C. elegans initiates by a conserved mechanism and is dispensable for homologous chromosome synapsis.

    abstract：:Chromosome segregation at meiosis I depends on pairing and crossing-over between homologs. In most eukaryotes, pairing culminates with formation of the proteinaceous synaptonemal complex (SC). In budding yeast, recombination initiates through double-strand DNA breaks (DSBs) and is thought to be essential for SC format...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/s0092-8674(00)81481-6

    authors： Dernburg AF,McDonald K,Moulder G,Barstead R,Dresser M,Villeneuve AM

    更新日期：1998-08-07 00:00:00

  • A role for exon sequences and splice-site proximity in splice-site selection.

    abstract：:Analysis of the in vitro splicing products of RNA precursors containing tandem duplications of the 5' or 3' splice sites of human beta-globin IVS 1 revealed that exon sequences play an important role in the relative use of the duplicated sites. These studies also show that the proximity of the 5' and 3' splice sites i...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/0092-8674(86)90343-0

    authors： Reed R,Maniatis T

    更新日期：1986-08-29 00:00:00

  • Direct visualization of protein transport and processing in the living cell by microinjection of specific antibodies.

    abstract：:We have prepared polyclonal antibodies to the cytoplasmic portion of the envelope glycoprotein G of vesicular stomatitis virus (VSV) by using synthetic peptides corresponding to either the 22 or 11 ultimate carboxy-terminal residues of the G as immunogens. When antibodies to the 22 residue peptide are microinjected in...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/0092-8674(84)90195-8

    authors： Arnheiter H,Dubois-Dalcq M,Lazzarini RA

    更新日期：1984-11-01 00:00:00

  • Cowpea mosaic virus RNAs have neither m7GpppN ... nor mono-, di- or triphosphates at their 5' ends.

    abstract：:32P-labeled cowpea mosaic virus (CPMV) RNAs were analyzed for their 5' termini by three different fingerprinting standard procedures. These analyses showed unequivocally that CPMV RNAs lack a structure like m7GpppN ... at their 5' termini. In addition, neither mono-, di- or triphosphorylated [(p)(p)pN ....] termini we...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/0092-8674(77)90318-x

    authors： Klootwijk J,Klein I,Zabel P,van Kammen A

    更新日期：1977-05-01 00:00:00

  • Mutations in the human Ca(2+)-sensing receptor gene cause familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism.

    abstract：:We demonstrate that mutations in the human Ca(2+)-sensing receptor gene cause familial hypocalciuric hypercalcemia (FHH) and neonatal severe hyperparathyroidism (NSHPT), two inherited conditions characterized by altered calcium homeostasis. The Ca(2+)-sensing receptor belongs to the superfamily of seven membrane-spann...

    journal_title：Cell

    pub_type： 杂志文章

    doi：10.1016/0092-8674(93)90617-y

    authors： Pollak MR,Brown EM,Chou YH,Hebert SC,Marx SJ,Steinmann B,Levi T,Seidman CE,Seidman JG

    更新日期：1993-12-31 00:00:00