The homeobox gene goosecoid controls cell migration in Xenopus embryos.

abstract：:Cytoplasmic dynein is a motor protein that exerts force on microtubules. To generate force for the movement of large organelles, dynein needs to be anchored, with the anchoring sites being typically located at the cell cortex. However, the mechanism by which dyneins target sites where they can generate large collectiv...

journal_title：Cell

authors： Ananthanarayanan V,Schattat M,Vogel SK,Krull A,Pavin N,Tolić-Nørrelykke IM

更新日期：2013-06-20 00:00:00

abstract：:Microbes that cause persistent infections (e.g., herpes viruses) do so by switching from fast-growing lytic states to slow-growing latent states. Waldman et al. have identified a single transcription factor that governs the switch between the lytic and latent forms of Toxoplasma gondii, a parasite that causes a persis...

journal_title：Cell

authors： Kochanowsky JA,Koshy AA

更新日期：2020-01-23 00:00:00

abstract：:During asymmetric cell divisions, mitotic spindles align along the axis of polarization. In invertebrates, spindle positioning requires Pins or related proteins and a G protein alpha subunit. A mammalian Pins, called LGN, binds Galphai and also interacts through an N-terminal domain with the microtubule binding protei...

journal_title：Cell

authors： Du Q,Macara IG

更新日期：2004-11-12 00:00:00

abstract：:The synthesis and secretion of plasminogen activator by cultured macrophages can be induced and stimulated by concanavalin A and by phorbol myristate acetate, and inhibited by such agents as glucocorticoids, mitotic inhibitors and compounds affecting cAMP metabolism. By the manipulation of stimulatory and inhibitory i...

journal_title：Cell

authors： Vassalli JD,Hamilton J,Reich E

更新日期：1977-07-01 00:00:00

abstract：:Most mutations in cancer genomes are thought to be acquired after the initiating event, which may cause genomic instability and drive clonal evolution. However, for acute myeloid leukemia (AML), normal karyotypes are common, and genomic instability is unusual. To better understand clonal evolution in AML, we sequenced...

journal_title：Cell

authors： Welch JS,Ley TJ,Link DC,Miller CA,Larson DE,Koboldt DC,Wartman LD,Lamprecht TL,Liu F,Xia J,Kandoth C,Fulton RS,McLellan MD,Dooling DJ,Wallis JW,Chen K,Harris CC,Schmidt HK,Kalicki-Veizer JM,Lu C,Zhang Q,Lin L,

更新日期：2012-07-20 00:00:00

abstract：:When the human beta-globin gene is transfected into Hela cells, no beta-globin RNA is detected unless the gene is linked to a viral transcription enhancer. In this paper we show that trans-acting adenovirus and herpesvirus (pseudorabies) transcriptional regulatory proteins can circumvent this enhancer requirement for ...

journal_title：Cell

authors： Green MR,Treisman R,Maniatis T

更新日期：1983-11-01 00:00:00

abstract：:The mitochondrial MURF4 gene of T. brucei has pronounced G versus C strand bias and heterogeneously sized transcripts, characteristic of genes encoding extensively edited transcripts. We find that MURF4 transcripts of T. brucei are extensively edited throughout by the addition and deletion of numerous uridines, creati...

journal_title：Cell

authors： Bhat GJ,Koslowsky DJ,Feagin JE,Smiley BL,Stuart K

更新日期：1990-06-01 00:00:00

abstract：:Vertebrate Hox genes are activated in a spatiotemporal sequence that reflects their clustered organization. While this colinear relationship is a property of most metazoans with an anterior to posterior polarity, the underlying molecular mechanisms are unknown. Previous work suggested that Hox genes were made progress...

journal_title：Cell

authors： Kondo T,Duboule D

更新日期：1999-04-30 00:00:00

abstract：:The tumor suppressor gene p53 regulates multiple cellular responses to DNA damage, but the transcriptional targets that specify these responses are incompletely understood. We describe a Drosophila p53 homolog and demonstrate that it can activate transcription from a promoter containing binding sites for human p53. Do...

journal_title：Cell

authors： Brodsky MH,Nordstrom W,Tsang G,Kwan E,Rubin GM,Abrams JM

更新日期：2000-03-31 00:00:00

abstract：:Phagosomes were traditionally thought to originate from an invagination and scission of the plasma membrane to form a distinct intracellular vacuole. An alternative model implicating the endoplasmic reticulum (ER) as a major component of nascent and maturing phagosomes was recently proposed (Gagnon et al., 2002). To r...

journal_title：Cell

authors： Touret N,Paroutis P,Terebiznik M,Harrison RE,Trombetta S,Pypaert M,Chow A,Jiang A,Shaw J,Yip C,Moore HP,van der Wel N,Houben D,Peters PJ,de Chastellier C,Mellman I,Grinstein S

更新日期：2005-10-07 00:00:00

abstract：:The mitotic checkpoint ensures proper chromosome segregation by delaying anaphase until chromosomes are aligned on the spindle. Following prolonged spindle damage, however, cells eventually exit mitosis and undergo apoptosis. We show here that a murine homolog of the yeast mitotic checkpoint gene BUB1 localizes to the...

journal_title：Cell

authors： Taylor SS,McKeon F

更新日期：1997-05-30 00:00:00

abstract：:Muscle atrophy (cachexia) in cancer patients is a life-threatening condition for which therapeutic options are limited. Zhou et al. (2010) now identify a new target for treating cachexia, the activin type-2 receptor (ActRIIB). In several mouse models of cachexia, the authors reversed wasting of skeletal and cardiac mu...

journal_title：Cell

authors： Tisdale MJ

更新日期：2010-08-20 00:00:00

abstract：:Finding a cell that reprograms in a nonstochastic manner without genetic manipulation has proven elusive. In this issue, Guo et al. report the identification of a cell defined by an ultrafast cycle whose progeny reprogram in a synchronous and rapid manner. ...

journal_title：Cell

authors： Chenoweth JG,McKay RD

更新日期：2014-02-13 00:00:00

abstract：:Tumor suppressors block the development of cancer and are often lost during tumor development. Papa et al. show that partial loss of normal PTEN tumor suppressor function can be compounded by additional disruption caused by the expression of inactive mutant PTEN protein. This has significant implications for patients ...

journal_title：Cell

authors： Leslie NR,den Hertog J

更新日期：2014-04-24 00:00:00

abstract：:The redox-regulated chaperone Hsp33 protects organisms against oxidative stress that leads to protein unfolding. Activation of Hsp33 is triggered by the oxidative unfolding of its own redox-sensor domain, making Hsp33 a member of a recently discovered class of chaperones that require partial unfolding for full chapero...

journal_title：Cell

authors： Reichmann D,Xu Y,Cremers CM,Ilbert M,Mittelman R,Fitzgerald MC,Jakob U

更新日期：2012-03-02 00:00:00

abstract：:Salmonella enterica invasion of host cells requires the reversible activation of the Rho-family GTPases Cdc42 and Rac1 by the bacterially encoded GEF SopE and the GAP SptP, which exert their function at different times during infection and are delivered into host cells by a type III secretion system. We found that Sop...

journal_title：Cell

authors： Kubori T,Galán JE

更新日期：2003-10-31 00:00:00

abstract：:Rho and rac, two members of the ras-related superfamily of small GTPases, regulate the polymerization of actin to produce stress fibers and lamellipodia, respectively. We report here that cdc42, another member of the rho family, triggers the formation of a third type of actin-based structure found at the cell peripher...

journal_title：Cell

authors： Nobes CD,Hall A

更新日期：1995-04-07 00:00:00

abstract：:Unique among leukocytes, neutrophils follow daily cycles of release from and migration back into the bone marrow, where they are eliminated. Because removal of dying cells generates homeostatic signals, we explored whether neutrophil elimination triggers circadian events in the steady state. Here, we report that the h...

journal_title：Cell

authors： Casanova-Acebes M,Pitaval C,Weiss LA,Nombela-Arrieta C,Chèvre R,A-González N,Kunisaki Y,Zhang D,van Rooijen N,Silberstein LE,Weber C,Nagasawa T,Frenette PS,Castrillo A,Hidalgo A

更新日期：2013-05-23 00:00:00

abstract：:HIV release requires TSG101, a cellular factor that sorts proteins into vesicles that bud into multivesicular bodies (MVB). To test whether other proteins involved in MVB biogenesis (the class E proteins) also participate in HIV release, we identified 22 candidate human class E proteins. These proteins were connected ...

journal_title：Cell

authors： von Schwedler UK,Stuchell M,Müller B,Ward DM,Chung HY,Morita E,Wang HE,Davis T,He GP,Cimbora DM,Scott A,Kräusslich HG,Kaplan J,Morham SG,Sundquist WI

更新日期：2003-09-19 00:00:00

abstract：:Temperature compensation of circadian clocks is an unsolved problem with relevance to the general phenomenon of biological compensation. We identify casein kinase 2 (CK2) as a key regulator of temperature compensation of the Neurospora clock by determining that two long-standing clock mutants, chrono and period-3, dis...

journal_title：Cell

authors： Mehra A,Shi M,Baker CL,Colot HV,Loros JJ,Dunlap JC

更新日期：2009-05-15 00:00:00

abstract：:Cultured NIH 3T3 cells devoid of endogenous EGF receptors were transfected with cDNA constructs encoding either the human EGF receptor or an EGF receptor mutant in which Lys721, a key residue in the ATP binding site, was replaced with an alanine residue. The mutant receptor was properly processed, and it displayed bot...

journal_title：Cell

authors： Honegger AM,Dull TJ,Felder S,Van Obberghen E,Bellot F,Szapary D,Schmidt A,Ullrich A,Schlessinger J

更新日期：1987-10-23 00:00:00

abstract：:The phage Mu transpososome is assembled by interactions of transposase subunits with the left (L) and right (R) ends of Mu and an enhancer (E) located in between. A metastable three-site complex LER progresses into a more stable type 0 complex in which a tetrameric transposase is poised for DNA cleavage. "Difference t...

journal_title：Cell

authors： Pathania S,Jayaram M,Harshey RM

更新日期：2002-05-17 00:00:00

abstract：:The yeast SIR2 gene is involved in regulating nucleosome phasing and transcription in the mating type system. We have found that SIR2 also plays another important role in the cell. Specifically, in wild-type SIR2 strains recombination between the tandemly repeated ribosomal RNA genes is depressed. In sir2 mutants, bot...

journal_title：Cell

authors： Gottlieb S,Esposito RE

更新日期：1989-03-10 00:00:00

abstract：:P-selectin binding to neutrophils requires a specific protein, P-selectin glycoprotein ligand 1 (PSGL-1), as well as sialyl-Lewis X (sLex) glycan determinants. We have found that a short segment near the amino terminus of PSGL-1 that contains a tyrosine sulfation consensus is essential for P-selectin adhesion and that...

journal_title：Cell

authors： Pouyani T,Seed B

更新日期：1995-10-20 00:00:00

abstract：:Notch signaling is broadly used to regulate cell-fate decisions. We have identified a gene, rumi, with a temperature-sensitive Notch phenotype. At 28 degrees C-30 degrees C, rumi clones exhibit a full-blown loss of Notch signaling in all tissues tested. However, at 18 degrees C only a mild Notch phenotype is evident. ...

journal_title：Cell

authors： Acar M,Jafar-Nejad H,Takeuchi H,Rajan A,Ibrani D,Rana NA,Pan H,Haltiwanger RS,Bellen HJ

更新日期：2008-01-25 00:00:00

abstract：:Study of Asians has previously indicated that deletion of alpha-globin structural genes is the predominant lesion in alpha-thalassemias and that Hb H disease occurs when three of four normal alpha loci per cell are deleted. To test the generality of this model, Hb H disease DNAs of both Asian and non-Asian origin were...

journal_title：Cell

authors： Orkin SH,Old J,Lazarus H,Altay C,Gurgey A,Weatherall DJ,Nathan DG

更新日期：1979-05-01 00:00:00

abstract：:We report genome-wide DNA data for 73 individuals from five archaeological sites across the Bronze and Iron Ages Southern Levant. These individuals, who share the "Canaanite" material culture, can be modeled as descending from two sources: (1) earlier local Neolithic populations and (2) populations related to the Chal...

journal_title：Cell

authors： Agranat-Tamir L,Waldman S,Martin MAS,Gokhman D,Mishol N,Eshel T,Cheronet O,Rohland N,Mallick S,Adamski N,Lawson AM,Mah M,Michel M,Oppenheimer J,Stewardson K,Candilio F,Keating D,Gamarra B,Tzur S,Novak M,Kalisher R

更新日期：2020-05-28 00:00:00

abstract：:We have fused DNA fragments derived from an Escherichia coli tRNALeu1 operon to the galK gene of E. coli to identify sequences necessary for the in vivo initiation of transcription and growth-rate-dependent regulation. Promoter sequences consisting of residues from -50 to +56 or -50 to +5 with respect to the in vivo s...

journal_title：Cell

authors： Duester G,Elford RM,Holmes WM

更新日期：1982-10-01 00:00:00

abstract：:V(D)J recombination of antigen receptor gene segments in B and T cells is mediated by the lymphoid-specific proteins RAG1 and RAG2. Now, Ji et al. (2010) demonstrate how RAG1 and RAG2 use DNA sequence specificity and modified histones within chromatin to target specific loci for V(D)J recombination at different stages...

journal_title：Cell

authors： Schlissel MS

更新日期：2010-04-30 00:00:00

abstract：:The brlA gene of A. nidulans mediates the developmental switch from the indeterminate, apical growth pattern of vegetative cells to the budding growth pattern of conidiophores. brlA encodes a 432 amino acid polypeptide containing two directly repeated motifs resembling the Zn(II) coordination sites first recognized in...

journal_title：Cell

authors： Adams TH,Boylan MT,Timberlake WE

更新日期：1988-07-29 00:00:00