Speeding to pluripotency.

abstract：:From the approximately 1,200 odorant receptor (OR) genes in the mouse genome, an olfactory sensory neuron is thought to express only one gene. The mechanisms of OR gene choice are not understood. A 2.1 kilobase region (the H element) adjacent to a cluster of seven OR genes has been proposed as a trans- and pan-enhance...

journal_title：Cell

authors： Fuss SH,Omura M,Mombaerts P

更新日期：2007-07-27 00:00:00

abstract：:Recent work has identified a cascade of membrane bound protein kinases in Ehrlich ascites tumor cells. These enzymes, designated PKL, PKS and PKM, are present in both Ehrlich tumor and mouse brain, but the cascade is active only in the tumor tissue. We have now purified a fourth protein kinase, PKF, that is also assoc...

journal_title：Cell

authors： Spector M,Pepinsky RB,Vogt VM,Racker E

更新日期：1981-07-01 00:00:00

abstract：:The single most frequent cancer-causing mutation across all heterotrimeric G proteins is R201C in Gαs. The current model explaining the gain-of-function activity of the R201 mutations is through the loss of GTPase activity and resulting inability to switch off to the GDP state. Here, we find that the R201C mutation ca...

journal_title：Cell

authors： Hu Q,Shokat KM

更新日期：2018-05-17 00:00:00

abstract：:Mutually exclusive expression within the var gene family of the malaria parasite Plasmodium falciparum is important for parasite survival and virulence. In this issue of Cell, Duraisingh et al. and Freitas-Junior et al. provide evidence for the role of Sir2-dependent alterations in chromatin structure and changes in s...

journal_title：Cell

authors： Deitsch KW

更新日期：2005-04-08 00:00:00

abstract：:We have analyzed two mutations of the white-eye gene, which arose in flies subject to I-R hybrid dysgenesis. These mutations are associated with insertions of apparently identical 5.4 kb sequences, which we have cloned. We believe that these insertions are copies of the I factor controlling I-R hybrid dysgenesis. The ...

journal_title：Cell

authors： Bucheton A,Paro R,Sang HM,Pelisson A,Finnegan DJ

更新日期：1984-08-01 00:00:00

abstract：:The chief mechanism used by bacteria for sensing their environment is based on two conserved proteins: a sensor histidine kinase (HK) and an effector response regulator (RR). The signal transduction process involves highly conserved domains of both proteins that mediate autokinase, phosphotransfer, and phosphatase act...

journal_title：Cell

authors： Casino P,Rubio V,Marina A

更新日期：2009-10-16 00:00:00

abstract：:In an era marked by the increasing prevalence of obesity, diabetes, and cardiovascular disease, the nuclear receptor peroxisome proliferator-activated receptor gamma (PPARgamma) has emerged as a transcriptional regulator of metabolism whose activity can be modulated by direct binding of small molecules. As the master ...

journal_title：Cell

authors： Lehrke M,Lazar MA

更新日期：2005-12-16 00:00:00

abstract：:Cancer cells enter a reversible drug-tolerant persister (DTP) state to evade death from chemotherapy and targeted agents. It is increasingly appreciated that DTPs are important drivers of therapy failure and tumor relapse. We combined cellular barcoding and mathematical modeling in patient-derived colorectal cancer mo...

journal_title：Cell

authors： Rehman SK,Haynes J,Collignon E,Brown KR,Wang Y,Nixon AML,Bruce JP,Wintersinger JA,Singh Mer A,Lo EBL,Leung C,Lima-Fernandes E,Pedley NM,Soares F,McGibbon S,He HH,Pollet A,Pugh TJ,Haibe-Kains B,Morris Q,Ramalho-San

更新日期：2021-01-07 00:00:00

abstract：:The transport kinetics of the influenza virus hemagglutinin from its site of synthesis to the apical plasma membrane of Madin-Darby canine kidney cells, a polarized epithelial cell line, were studied by a sensitive tryptic assay. Hemagglutinin acquired terminal sugars, as judged by sensitivity to endo-beta-N-acetylglu...

journal_title：Cell

authors： Matlin KS,Simons K

更新日期：1983-08-01 00:00:00

abstract：:How is the characteristic shape of an organelle generated? Recent work has provided insight into how the tubular network of the endoplasmic reticulum (ER) is formed. The tubules themselves are shaped by the reticulons and DP1/Yop1p, whereas their fusion into a network is brought about by membrane-bound GTPases that in...

journal_title：Cell

authors： Hu J,Prinz WA,Rapoport TA

更新日期：2011-12-09 00:00:00

abstract：:Fragile X syndrome (FXS), the leading monogenic cause of intellectual disability and autism, results from loss of function of the RNA-binding protein FMRP. Here, we show that FMRP regulates translation of neuronal nitric oxide synthase 1 (NOS1) in the developing human neocortex. Whereas NOS1 mRNA is widely expressed, ...

journal_title：Cell

authors： Kwan KY,Lam MM,Johnson MB,Dube U,Shim S,Rašin MR,Sousa AM,Fertuzinhos S,Chen JG,Arellano JI,Chan DW,Pletikos M,Vasung L,Rowitch DH,Huang EJ,Schwartz ML,Willemsen R,Oostra BA,Rakic P,Heffer M,Kostović I,Judaš M,

更新日期：2012-05-11 00:00:00

abstract：:We present evidence that Tn10 transposase promotes double strand breaks and single strand joints at Tn10 termini in vivo. Plasmids containing a shortened Tn10 element and a transposase overproducer fusion give rise, upon transposase induction, to new DNA species. The most prominent class is a circularized transposon m...

journal_title：Cell

authors： Morisato D,Kleckner N

更新日期：1984-11-01 00:00:00

abstract：:Proteotypes, like genotypes, have been found to vary between individuals in several studies, but consistent molecular functional traits across studies remain to be quantified. In a meta-analysis of 11 proteomics datasets from humans and mice, we use co-variation of proteins in known functional modules across datasets ...

journal_title：Cell

authors： Romanov N,Kuhn M,Aebersold R,Ori A,Beck M,Bork P

更新日期：2019-05-16 00:00:00

abstract：:The kinetics of association of epidermal growth factor (EGF) and diferric-transferrin (TF) with clathrin-coated membranes of KB cells were examined using anti-clathrin antibody bound to Staphylococcus aureus. The ligands were bound to cells at 4 degrees C and after warming to 30 degrees C for 5 min, both ligands were ...

journal_title：Cell

authors： Hanover JA,Willingham MC,Pastan I

更新日期：1984-12-01 00:00:00

abstract：:Thymocyte commitment to the CD4 helper versus CD8 cytotoxic lineage has not been satisfactorily established. Two models have been elaborated: one based on instruction, the other on selection. Most previous results support the instructive model, but our comparison of thymocyte differentiation in MHC class II-, class I-...

journal_title：Cell

authors： Chan SH,Cosgrove D,Waltzinger C,Benoist C,Mathis D

更新日期：1993-04-23 00:00:00

abstract：:Among its multiple functions, p53 is a critical regulator of TGF-beta responses. Sasai et al. (2008) now identify a new p53 inhibitory protein, XFDL156. During embryonic development, this factor is expressed in the ectoderm germ layer and maintains the pluripotency of ectodermal cells by inhibiting TGF-beta target gen...

journal_title：Cell

authors： Piccolo S

更新日期：2008-05-30 00:00:00

abstract：:X inactivation results in inactivation of one X chromosome to compensate for gene dosage differences between mammalian females and males. It requires the X-inactivation center (Xic) and Xist in cis. We report that introducing 450 kb of murine Xic/Xist sequences onto autosomes activates female dosage compensation in ma...

journal_title：Cell

authors： Lee JT,Strauss WM,Dausman JA,Jaenisch R

更新日期：1996-07-12 00:00:00

abstract：:During embryogenesis, cells from the ventral and dorsal parts of the somites give rise to sclerotome and dermomyotome, respectively. Dermomyotome contains skeletal muscle precursors that are determined by the MyoD family of myogenic factors. We have isolated a novel myogenic repressor, I-mf (Inhibitor of MyoD family),...

journal_title：Cell

authors： Chen CM,Kraut N,Groudine M,Weintraub H

更新日期：1996-09-06 00:00:00

abstract：:Cortical layer 1 (L1) interneurons have been proposed as a hub for attentional modulation of underlying cortex, but the transformations that this circuit implements are not known. We combined genetically targeted voltage imaging with optogenetic activation and silencing to study the mechanisms underlying sensory proce...

journal_title：Cell

authors： Fan LZ,Kheifets S,Böhm UL,Wu H,Piatkevich KD,Xie ME,Parot V,Ha Y,Evans KE,Boyden ES,Takesian AE,Cohen AE

更新日期：2020-02-06 00:00:00

abstract：:To study the insertion of multispanning membrane proteins into the endoplasmic reticulum, we constructed novel proteins on the cDNA level by repeating, up to four times, the internal signal-anchor domain of the asialoglycoprotein receptor H1. Upon in vitro translation in the presence of microsomes, these polypeptides ...

journal_title：Cell

authors： Wessels HP,Spiess M

更新日期：1988-10-07 00:00:00

abstract：:The yeast [PSI+] factor is inherited by a prion mechanism involving self-propagating Sup35p aggregates. We find that Sup35p prion function is conserved among distantly related yeasts. As with mammalian prions, a species barrier inhibits prion induction between Sup35p from different yeast species. This barrier is faith...

journal_title：Cell

authors： Santoso A,Chien P,Osherovich LZ,Weissman JS

更新日期：2000-01-21 00:00:00

abstract：:We have identified mutations in Drosophila endophilin to study its function in vivo. Endophilin is required presynaptically at the neuromuscular junction, and absence of Endophilin dramatically impairs endocytosis in vivo. Mutant larvae that lack Endophilin fail to take up FM1-43 dye in synaptic boutons, indicating an...

journal_title：Cell

authors： Verstreken P,Kjaerulff O,Lloyd TE,Atkinson R,Zhou Y,Meinertzhagen IA,Bellen HJ

更新日期：2002-04-05 00:00:00

abstract：:We have analyzed the viral DNA sequences persisting in HE C19, a clonal line of hamster embryo cells transformed in vitro by human adenovirus 12 (Ad 12), a member of highly oncogenic group A. Saturation-hybridization of in vitro labeled Ad 12 DNA (2-4 x 10(8) cpm/mug) with HE C19 DNA showed that 93-100% of viral DNA s...

journal_title：Cell

authors： Green MR,Chinnadurai G,Mackey JK,Green M

更新日期：1976-03-01 00:00:00

abstract：:SecA, the peripheral subunit of E. coli preprotein translocase, alternates between a membrane inserted and a deinserted state as part of the catalytic cycle of preprotein translocation. When SecA is complexed with SecY/E and preprotein, ATP drives a profound conformational change, leading to membrane insertion of a 30...

journal_title：Cell

authors： Economou A,Wickner W

更新日期：1994-09-09 00:00:00

abstract：:By chromosome walking in the major histocompatibility complex (MHC) of the BALB/c mouse, we have linked the K region to the I region at the molecular level. Forty-nine overlapping cosmid clones define a stretch of about 600 kb of DNA containing 2 class I and 7 class II genes. Eleven independent recombination events we...

journal_title：Cell

authors： Steinmetz M,Stephan D,Fischer Lindahl K

更新日期：1986-03-28 00:00:00

abstract：:We show that a functional component of the C. elegans mitotic machinery regulates X chromosome gene expression. This protein, MIX-1, is a member of the dosage compensation complex that associates specifically with hermaphrodite X chromosomes to reduce their gene expression during interphase. MIX-1 also associates with...

journal_title：Cell

authors： Lieb JD,Albrecht MR,Chuang PT,Meyer BJ

更新日期：1998-01-23 00:00:00

abstract：:The stomata of plants regulate gas exchange and water transpiration in response to changing environmental conditions. New work reveals that stomata also have an important role in host defense. In this issue of Cell, Melotto et al. (2006) show that stomata close upon detection of potential microbial pathogens to preven...

journal_title：Cell

authors： Schulze-Lefert P,Robatzek S

更新日期：2006-09-08 00:00:00

abstract：:In Saccharomyces cerevisiae, mothers and daughters have distinct fates. We show that Cbk1 kinase and its interacting protein Mob2 regulate this asymmetry by inducing daughter-specific genetic programs. Daughter-specific expression is due to Cbk1/Mob2-dependent activation and localization of the Ace2 transcription fact...

journal_title：Cell

authors： Colman-Lerner A,Chin TE,Brent R

更新日期：2001-12-14 00:00:00

abstract：:Two-component signal transduction systems are the predominant means by which bacteria sense and respond to environmental stimuli. Bacteria often employ tens or hundreds of these paralogous signaling systems, comprised of histidine kinases (HKs) and their cognate response regulators (RRs). Faithful transmission of info...

journal_title：Cell

authors： Skerker JM,Perchuk BS,Siryaporn A,Lubin EA,Ashenberg O,Goulian M,Laub MT

更新日期：2008-06-13 00:00:00

abstract：:This paper describes a model for the structure of DNA contained in three morphologically similar bacteriophages--T7, P22 and phiCd-1--based on the transient electric dichroism of intact phage. The reduced dichroism of each of the phages at perfect orientation is within the range +0.12 to +0.19. Assuming that the phage...

journal_title：Cell

authors： Kosturko LD,Hogan M,Dattagupta N

更新日期：1979-03-01 00:00:00