Rewiring the specificity of two-component signal transduction systems.

abstract：:Gene duplication is a major evolutionary force driving adaptation and speciation, as it allows for the acquisition of new functions and can augment or diversify existing functions. Here, we report a gene duplication event that yielded another outcome--the generation of antagonistic functions. One product of this dupli...

journal_title：Cell

authors： Shum EY,Jones SH,Shao A,Dumdie J,Krause MD,Chan WK,Lou CH,Espinoza JL,Song HW,Phan MH,Ramaiah M,Huang L,McCarrey JR,Peterson KJ,De Rooij DG,Cook-Andersen H,Wilkinson MF

更新日期：2016-04-07 00:00:00

abstract：:We have isolated cDNA clones generated from the mRNA encoding the opsin apoprotein of bovine rhodopsin and used these cDNAs to isolate genomic DNA clones containing the complete opsin gene. Nucleotide sequence analysis of the cloned DNAs has yielded a complete amino acid sequence for bovine rhodopsin and provided an i...

journal_title：Cell

authors： Nathans J,Hogness DS

更新日期：1983-10-01 00:00:00

abstract：:Previous work from our laboratory has demonstrated that a subclass of the aminoglycoside antibiotics, those containing the drug fragment paromamine, stimulates mistranslation in cell-free protein-synthesizing systems derived from eucaryotic cells. We report here experiments which show that the ciliate Tetrahymena ther...

journal_title：Cell

authors： Palmer E,Wilhelm JM

更新日期：1978-02-01 00:00:00

abstract：:Excessive sun tanning can result in addictive behavior. In this issue of Cell, Fell et al. utilize a combination of behavioral pharmacology and transgenic mice to demonstrate that chronic UV light exposure recruits p53 signaling in keratinocytes, subsequently increasing β-endorphin signaling at opioid receptors, and p...

journal_title：Cell

authors： Tejeda HA,Bonci A

更新日期：2014-06-19 00:00:00

abstract：:The protein product of the human Duchenne muscular dystrophy locus (DMD) and its mouse homolog (mDMD) have been identified by using polyclonal antibodies directed against fusion proteins containing two distinct regions of the mDMD cDNA. The DMD protein is shown to be approximately 400 kd and to represent approximately...

journal_title：Cell

authors： Hoffman EP,Brown RH Jr,Kunkel LM

更新日期：1987-12-24 00:00:00

abstract：:TET-mediated 5-methyl cytosine (5mC) oxidation acts in epigenetic regulation, stem cell development, and cancer. Hu et al. now determine the crystal structure of the TET2 catalytic domain bound to DNA, shedding light on 5mC-DNA substrate recognition and the catalytic mechanism of 5mC oxidation. ...

journal_title：Cell

authors： Tsai CL,Tainer JA

更新日期：2013-12-19 00:00:00

abstract：:NPR1 is an essential regulator of plant systemic acquired resistance (SAR), which confers immunity to a broad-spectrum of pathogens. SAR induction results in accumulation of the signal molecule salicylic acid (SA), which induces defense gene expression via activation of NPR1. We found that in an uninduced state, NPR1 ...

journal_title：Cell

authors： Mou Z,Fan W,Dong X

更新日期：2003-06-27 00:00:00

abstract：:Yeast chromosomes terminate in tracts of simple repetitive DNA (poly[G1-3T]). Mutations in the gene TEL1 result in shortened telomeres. Sequence analysis of TEL1 indicates that it encodes a very large (322 kDa) protein with amino acid motifs found in phosphatidylinositol/protein kinases. The closest homolog to TEL1 is...

journal_title：Cell

authors： Greenwell PW,Kronmal SL,Porter SE,Gassenhuber J,Obermaier B,Petes TD

更新日期：1995-09-08 00:00:00

abstract：:Synonymous mutations change the sequence of a gene without directly altering the sequence of the encoded protein. Here, we present evidence that these "silent" mutations frequently contribute to human cancer. Selection on synonymous mutations in oncogenes is cancer-type specific, and although the functional consequenc...

journal_title：Cell

authors： Supek F,Miñana B,Valcárcel J,Gabaldón T,Lehner B

更新日期：2014-03-13 00:00:00

abstract：:Is the Café Scientifique a fashionable by-product of a comfortable age or an indicator of the changing relationship between science and society? ...

journal_title：Cell

authors： Dallas D

更新日期：2006-07-28 00:00:00

abstract：:Salmonella enterica invasion of host cells requires the reversible activation of the Rho-family GTPases Cdc42 and Rac1 by the bacterially encoded GEF SopE and the GAP SptP, which exert their function at different times during infection and are delivered into host cells by a type III secretion system. We found that Sop...

journal_title：Cell

authors： Kubori T,Galán JE

更新日期：2003-10-31 00:00:00

abstract：:Chemical modifications of histones and DNA, such as histone methylation, histone acetylation, and DNA methylation, play critical roles in epigenetic gene regulation. Many of the enzymes that add or remove such chemical modifications are known, or might be suspected, to be sensitive to changes in intracellular metaboli...

journal_title：Cell

authors： Kaelin WG Jr,McKnight SL

更新日期：2013-03-28 00:00:00

abstract：:The Arabidopsis floral homeotic gene AGAMOUS (AG) is required for development of the reproductive organs (stamens and carpels). In ag mutants, the loss of AG function leads to the conversion of these organs to the perianth organs (petals and sepals). In contrast, mutations in another floral homeotic gene, APETALA2 (AP...

journal_title：Cell

authors： Mizukami Y,Ma H

更新日期：1992-10-02 00:00:00

abstract：:Normal homeostatic functions of adult stem cells have rhythmic daily oscillations that are believed to become arrhythmic during aging. Unexpectedly, we find that aged mice remain behaviorally circadian and that their epidermal and muscle stem cells retain a robustly rhythmic core circadian machinery. However, the osci...

journal_title：Cell

authors： Solanas G,Peixoto FO,Perdiguero E,Jardí M,Ruiz-Bonilla V,Datta D,Symeonidi A,Castellanos A,Welz PS,Caballero JM,Sassone-Corsi P,Muñoz-Cánoves P,Benitah SA

更新日期：2017-08-10 00:00:00

abstract：:We have characterized an aberrant allele of a variably spliced Drosophila tropomyosin gene. The allele was recovered from the flightless Ifm(3)3 strain, which has been shown to have structurally and functionally abnormal indirect flight muscles. The transcribed portion of the mutant gene is interrupted by an 8,8 kb in...

journal_title：Cell

authors： Karlik CC,Fyrberg EA

更新日期：1985-05-01 00:00:00

abstract：:We have isolated a conditional lethal mutant of bacteriophage 12 which makes plaques only on E. coli strains carrying a UGA suppressor. It grows normally in nonsuppressing hosts but does not lyse such strains. The mutation complements with amber mutations in each of the three known phage cistrons. These observations l...

journal_title：Cell

authors： Model P,Webster RE,Zinder ND

更新日期：1979-10-01 00:00:00

abstract：:The inhibitor of apoptosis (IAP) proteins suppress cell death by inhibiting the catalytic activity of caspases. Here we present the crystal structure of caspase-7 in complex with a potent inhibitory fragment from XIAP at 2.45 A resolution. An 18-residue XIAP peptide binds the catalytic groove of caspase-7, making exte...

journal_title：Cell

authors： Chai J,Shiozaki E,Srinivasula SM,Wu Q,Datta P,Alnemri ES,Shi Y

更新日期：2001-03-09 00:00:00

abstract：:beta-glucocerebrosidase, the enzyme defective in Gaucher disease, is targeted to the lysosome independently of the mannose-6-phosphate receptor. Affinity-chromatography experiments revealed that the lysosomal integral membrane protein LIMP-2 is a specific binding partner of beta-glucocerebrosidase. This interaction in...

journal_title：Cell

authors： Reczek D,Schwake M,Schröder J,Hughes H,Blanz J,Jin X,Brondyk W,Van Patten S,Edmunds T,Saftig P

更新日期：2007-11-16 00:00:00

abstract：:Periodic transcription of yeast histone genes has been demonstrated by DNA excess filter hybridization of in vivo pulse-labeled RNA isolated from synchronous cell cultures. Using strains carrying cell division cycle (cdc) mutations, we show that both activation and termination of transcription are determined by tempor...

journal_title：Cell

authors： Hereford L,Bromley S,Osley MA

更新日期：1982-08-01 00:00:00

abstract：:We present evidence that the genes encoding U3 snRNA in plants are transcribed by RNA polymerase III (pol III) and not by RNA polymerase II (pol II) as in vertebrates or lower eukaryotes. The U3 gene is the only known example of a gene transcribed by different polymerases in different organisms. It is possible to conv...

journal_title：Cell

authors： Kiss T,Marshallsay C,Filipowicz W

更新日期：1991-05-03 00:00:00

abstract：:RGS proteins are GTPase activators for heterotrimeric G proteins. We report here the 2.8 A resolution crystal structure of the RGS protein RGS4 complexed with G(i alpha1)-Mg2+-GDP-AlF4 . Only the core domain of RGS4 is visible in the crystal. The core domain binds to the three switch regions of G(i alpha1), but does n...

journal_title：Cell

authors： Tesmer JJ,Berman DM,Gilman AG,Sprang SR

更新日期：1997-04-18 00:00:00

abstract：:Genetic analyses in Drosophila have demonstrated that the multipass membrane protein Smoothened (Smo) is essential for all Hedgehog signaling. We show that Smo acts epistatic to Ptc1 to mediate Shh and Ihh signaling in the early mouse embryo. Smo and Shh/Ihh compound mutants have identical phenotypes: embryos fail to ...

journal_title：Cell

authors： Zhang XM,Ramalho-Santos M,McMahon AP

更新日期：2001-06-15 00:00:00

abstract：:Spinal muscular atrophy (SMA) is an often fatal neuromuscular disease that has been directly linked to the protein product of the Survival of Motor Neurons (SMN) gene. The SMN protein is tightly associated with a novel protein, SIP1, and together they form a complex with several spliceosomal snRNP proteins. Here we sh...

journal_title：Cell

authors： Fischer U,Liu Q,Dreyfuss G

更新日期：1997-09-19 00:00:00

abstract：:We determined the nucleotide sequences of all coding regions and a significant part of the flanking regions of the chicken c-src gene, which is a cellular homolog of the v-src gene of Rous sarcoma virus. The c-src gene consists of 12 exons; the boundaries of the exons were determined by assuming that the amino acid se...

journal_title：Cell

authors： Takeya T,Hanafusa H

更新日期：1983-03-01 00:00:00

abstract：:The anaphase-promoting complex (APC), or cyclosome, is an E3 ubiquitin-protein ligase that collaborates with E2 ubiquitin-conjugating enzymes to assemble polyubiquitin chains on proteins important for cell-cycle progression. It remains unclear how the APC - or many other E3s - promotes the multiple distinct reactions ...

journal_title：Cell

authors： Rodrigo-Brenni MC,Morgan DO

更新日期：2007-07-13 00:00:00

abstract：:We find that inactivation of a Drosophila homolog of the tumor suppressor APC (D-APC) causes retinal neuronal degeneration and pigment cell hypertrophy, a phenotype remarkably similar to that found in humans with germline APC mutations. Retinal degeneration in the D-APC mutant results from apoptotic cell death, which ...

journal_title：Cell

authors： Ahmed Y,Hayashi S,Levine A,Wieschaus E

更新日期：1998-06-26 00:00:00

abstract：:The promise of human genetics and genomics is nothing less than a fully tailored life, starting with medical treatments, diets, and preventative care all styled around a single genome. There's a lighter side as well where consumer genomics companies are helping people understand themselves and their families. Lara Sze...

journal_title：Cell

authors：

更新日期：2019-03-21 00:00:00

abstract：:D-type cyclins (cyclins D1, D2, and D3) are regarded as essential links between cell environment and the core cell cycle machinery. We tested the requirement for D-cyclins in mouse development and in proliferation by generating mice lacking all D-cyclins. We found that these cyclin D1(-/-)D2(-/-)D3(-/-) mice develop u...

journal_title：Cell

authors： Kozar K,Ciemerych MA,Rebel VI,Shigematsu H,Zagozdzon A,Sicinska E,Geng Y,Yu Q,Bhattacharya S,Bronson RT,Akashi K,Sicinski P

更新日期：2004-08-20 00:00:00

abstract：:Cholera toxin inhibition of progesterone-induced meiosis of Xenopus laevis oocytes in vitro has been correlated with increased cAMP levels. Inhibition of germinal vesicle breakdown (Gvbd) and cAMP increase occurred after a lag period of 2 hr, when cholera toxin was injected, or 4--5 hr, when applied externally. The ab...

journal_title：Cell

authors： Schorderet-Slatkine S,Schorderet M,Boquet P,Godeau F,Baulieu EE

更新日期：1978-12-01 00:00:00

abstract：:Vaccinia virus recombinants were generated which express the intact gp70/p15E of Friend mink cell focus inducing virus (F-MCFV) or truncated forms of the glycoprotein that lack the transmembrane and cytoplasmic domains. The transport of the intact and truncated envelope glycoproteins to apical or basolateral surfaces ...

journal_title：Cell

authors： Stephens EB,Compans RW

更新日期：1986-12-26 00:00:00