Abstract：
:We have characterized an aberrant allele of a variably spliced Drosophila tropomyosin gene. The allele was recovered from the flightless Ifm(3)3 strain, which has been shown to have structurally and functionally abnormal indirect flight muscles. The transcribed portion of the mutant gene is interrupted by an 8,8 kb insertion of middle repetitive DNA having a structure typical of copia-like Drosophila mobile elements. The insertion is positioned so as to interrupt an exon sequence in one splicing mode and, simultaneously, an intron in the alternate mode. As a consequence of the insertion the allele fails to direct synthesis of the flight muscle-specific tropomyosin isoform, but remains capable of specifying a second isoform, which accumulates in nonfibrillar Drosophila muscles.
journal_name
Celljournal_title
Cellauthors
Karlik CC,Fyrberg EAdoi
10.1016/0092-8674(85)90061-3subject
Has Abstractpub_date
1985-05-01 00:00:00pages
57-66issue
1eissn
0092-8674issn
1097-4172pii
0092-8674(85)90061-3journal_volume
41pub_type
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