Mouse development and cell proliferation in the absence of D-cyclins.

abstract：:Ocean microbial communities strongly influence the biogeochemistry, food webs, and climate of our planet. Despite recent advances in understanding their taxonomic and genomic compositions, little is known about how their transcriptomes vary globally. Here, we present a dataset of 187 metatranscriptomes and 370 metagen...

journal_title：Cell

authors： Salazar G,Paoli L,Alberti A,Huerta-Cepas J,Ruscheweyh HJ,Cuenca M,Field CM,Coelho LP,Cruaud C,Engelen S,Gregory AC,Labadie K,Marec C,Pelletier E,Royo-Llonch M,Roux S,Sánchez P,Uehara H,Zayed AA,Zeller G,Carmichael

更新日期：2019-11-14 00:00:00

abstract：:Recent studies suggest that local translation of mRNA within axons plays a key role in two aspects of growth cone navigation. One line of evidence implies a local synthesis of proteins that mediate growth cone collapse and turning in response to guidance cues; another indicates that growth cones possess the machinery ...

journal_title：Cell

authors： Steward O

更新日期：2002-09-06 00:00:00

abstract：:Bcl-2 protein is able to repress a number of apoptotic death programs. To investigate the mechanism of Bcl-2's effect, we examined whether Bcl-2 interacted with other proteins. We identified an associated 21 kd protein partner, Bax, that has extensive amino acid homology with Bcl-2, focused within highly conserved dom...

journal_title：Cell

authors： Oltvai ZN,Milliman CL,Korsmeyer SJ

更新日期：1993-08-27 00:00:00

abstract：:Oligodendrocyte-specific protein (OSP)/claudin-11 is a recently identified transmembrane protein found in CNS myelin and testis with unknown function. Herein we demonstrate that Osp null mice exhibit both neurological and reproductive deficits: CNS nerve conduction is slowed, hindlimb weakness is conspicuous, and male...

journal_title：Cell

authors： Gow A,Southwood CM,Li JS,Pariali M,Riordan GP,Brodie SE,Danias J,Bronstein JM,Kachar B,Lazzarini RA

更新日期：1999-12-10 00:00:00

abstract：:A mechanism by which the nerve growth factor (NGF) signal is transduced to the nucleus to induce gene expression has been characterized. An NGF-inducible, Ras-dependent protein kinase has been identified that catalyzes the phosphorylation of the cyclic AMP response element-binding protein (CREB) at Ser-133. Phosphoryl...

journal_title：Cell

authors： Ginty DD,Bonni A,Greenberg ME

更新日期：1994-06-03 00:00:00

abstract：:Large numbers of inbred laboratory rat strains have been developed for a range of complex disease phenotypes. To gain insights into the evolutionary pressures underlying selection for these phenotypes, we sequenced the genomes of 27 rat strains, including 11 models of hypertension, diabetes, and insulin resistance, al...

journal_title：Cell

authors： Atanur SS,Diaz AG,Maratou K,Sarkis A,Rotival M,Game L,Tschannen MR,Kaisaki PJ,Otto GW,Ma MC,Keane TM,Hummel O,Saar K,Chen W,Guryev V,Gopalakrishnan K,Garrett MR,Joe B,Citterio L,Bianchi G,McBride M,Dominiczak A

更新日期：2013-08-01 00:00:00

abstract：:Toll-like receptors (TLRs) are membrane-bound sensors that detect and respond to microbial infection. Two studies in Cell, one in this issue, reveal how TLRs recognize their ligands. Kim et al. (2007) recently reported the structure of TLR4 bound to the accessory protein MD-2 and its antagonist, the drug eritoran. In ...

journal_title：Cell

authors： Brodsky I,Medzhitov R

更新日期：2007-09-21 00:00:00

abstract：:Septate and tight junctions are thought to seal neighboring cells together and to function as barriers between epithelial cells. We have characterized a novel member of the neurexin family, Neurexin IV (NRX), which is localized to septate junctions (SJs) of epithelial and glial cells. NRX is a transmembrane protein wi...

journal_title：Cell

authors： Baumgartner S,Littleton JT,Broadie K,Bhat MA,Harbecke R,Lengyel JA,Chiquet-Ehrismann R,Prokop A,Bellen HJ

更新日期：1996-12-13 00:00:00

abstract：:As the pipeline of new antibiotics slows to a trickle, scientists are developing innovative strategies to unearth antibacterial compounds in unexpected places. ...

journal_title：Cell

authors： von Bubnoff A

更新日期：2006-12-01 00:00:00

abstract：:Tyrosyl phosphorylation is implicated in the mechanism of insulin action. Mutation of the beta-subunit of the insulin receptor by substitution of tyrosyl residue 960 with phenylalanine had no effect on insulin-stimulated autophosphorylation or phosphotransferase activity of the purified receptor. However, unlike the n...

journal_title：Cell

authors： White MF,Livingston JN,Backer JM,Lauris V,Dull TJ,Ullrich A,Kahn CR

更新日期：1988-08-26 00:00:00

abstract：:The intermediate filament proteins, desmin and vimentin, are phosphorylated in skeletal muscle cells in vivo. Desmin kinase activities have been purified from mature chicken skeletal muscle and identified as the cAMP-dependent kinases. Chicken skeletal muscle contains two cAMP-dependent protein kinases which are simil...

journal_title：Cell

authors： O'Connor CM,Gard DL,Lazarides E

更新日期：1981-01-01 00:00:00

abstract：:We have prepared polyclonal antibodies to the cytoplasmic portion of the envelope glycoprotein G of vesicular stomatitis virus (VSV) by using synthetic peptides corresponding to either the 22 or 11 ultimate carboxy-terminal residues of the G as immunogens. When antibodies to the 22 residue peptide are microinjected in...

journal_title：Cell

authors： Arnheiter H,Dubois-Dalcq M,Lazzarini RA

更新日期：1984-11-01 00:00:00

abstract：:Physiological concentrations of dihydrotestosterone (DHT) can specifically induce the release of fibrinolysin from androgen-dependent mammary carcinoma (Shionogi SC-115) cells in vitro. No fibrinolytic activity was observed in cells cultured either in the absence of DHT or presence of pharmacological concentrations of...

journal_title：Cell

authors： Mak TW,Rutledge G,Sutherland DJ

更新日期：1976-02-01 00:00:00

abstract：:Gene silencing is instrumental to interrogate gene function and holds promise for therapeutic applications. Here, we repurpose the endogenous retroviruses' silencing machinery of embryonic stem cells to stably silence three highly expressed genes in somatic cells by epigenetics. This was achieved by transiently expres...

journal_title：Cell

authors： Amabile A,Migliara A,Capasso P,Biffi M,Cittaro D,Naldini L,Lombardo A

更新日期：2016-09-22 00:00:00

abstract：:Studies on several recently discovered error-prone DNA polymerases reveal novel structures that may explain the low fidelity of this general class of enzymes, a number of which are involved in the replicative bypass (translesion synthesis) of base damage in DNA. ...

journal_title：Cell

authors： Friedberg EC,Fischhaber PL,Kisker C

更新日期：2001-10-05 00:00:00

abstract：:Reactivation of human cytomegalovirus (HCMV) results in severe disease in AIDS patients and immunocompromised patients receiving blood transfusions or organ or bone marrow grafts. Although the site of HCMV latency is unknown, blood cells have been implicated as a viral reservoir. In this study, we demonstrate HCMV rea...

journal_title：Cell

authors： Söderberg-Nauclér C,Fish KN,Nelson JA

更新日期：1997-10-03 00:00:00

abstract：:A basic B-cell-specific protein of 35,000 daltons (XM1) is expressed at a high rate--comparable to actin--in resting splenic B lymphocytes of various species. Splenic or thymic T cells or fibroblasts do not express this protein. Upon polyclonal stimulation of B lymphocytes or in proliferating B-lymphocyte-derived cell...

journal_title：Cell

authors： Rahmsdorf HJ,Mallick U,Ponta H,Herrlich P

更新日期：1982-06-01 00:00:00

abstract：:A Drosophila gene with similarity to the mammalian Ras GTPase activating protein has been isolated in screens for mutations that affect eye development. Inactivation of the locus, Gap1, mimics constitutive activation of the Sevenless receptor tyrosine kinase and eliminates the need for a functional Sevenless protein i...

journal_title：Cell

authors： Gaul U,Mardon G,Rubin GM

更新日期：1992-03-20 00:00:00

abstract：:Loss of cell polarity proteins such as Scribble induces neoplasia in Drosophila by promoting uncontrolled proliferation. In mammals, the role that polarity proteins play during tumorigenesis is not well understood. Here, we demonstrate that depletion of Scribble in mammary epithelia disrupts cell polarity, blocks thre...

journal_title：Cell

authors： Zhan L,Rosenberg A,Bergami KC,Yu M,Xuan Z,Jaffe AB,Allred C,Muthuswamy SK

更新日期：2008-11-28 00:00:00

abstract：:Inductive signals cause conversion of mesenchyme into epithelia during the formation of many organs. Yet a century of study has not revealed the inducing molecules. Using a standard model of induction, we found that ureteric bud cells secrete factors that convert kidney mesenchyme to epithelia that, remarkably, then f...

journal_title：Cell

authors： Barasch J,Yang J,Ware CB,Taga T,Yoshida K,Erdjument-Bromage H,Tempst P,Parravicini E,Malach S,Aranoff T,Oliver JA

更新日期：1999-11-12 00:00:00

abstract：:Members of the E2F transcription factor family (E2F-1-E2F-5) are believed to be critical positive regulators of cell cycle progression in eukaryotes although the in vivo functions of the individual E2Fs have not been elucidated. Mice were generated that lack E2F-1 and, surprisingly, these mice develop and reproduce no...

journal_title：Cell

authors： Field SJ,Tsai FY,Kuo F,Zubiaga AM,Kaelin WG Jr,Livingston DM,Orkin SH,Greenberg ME

更新日期：1996-05-17 00:00:00

abstract：:DNA demethylating agents are approved for some blood malignancies and are under active investigation in solid tumors, but how these drugs work has remained unclear. In this issue of Cell, two groups show that these agents activate a toxic cellular antiviral program through transcriptional activation of endogenous retr...

journal_title：Cell

authors： Licht JD

更新日期：2015-08-27 00:00:00

abstract：:Plant seedling development is capable of following 1 of 2 distinct morphogenic pathways: skotomorphogenesis in darkness and photomorphogenesis in light. Dark-grown Arabidopsis seedlings with recessive mutations at the constitutively photomorphogenic (COP1) locus indicate that the wild-type COP1 protein represses photo...

journal_title：Cell

authors： Deng XW,Matsui M,Wei N,Wagner D,Chu AM,Feldmann KA,Quail PH

更新日期：1992-11-27 00:00:00

abstract：:The transcription factor ATF2 elicits oncogenic activities in melanoma and tumor suppressor activities in nonmalignant skin cancer. Here, we identify that ATF2 tumor suppressor function is determined by its ability to localize at the mitochondria, where it alters membrane permeability following genotoxic stress. The a...

journal_title：Cell

authors： Lau E,Kluger H,Varsano T,Lee K,Scheffler I,Rimm DL,Ideker T,Ronai ZA

更新日期：2012-02-03 00:00:00

abstract：:A novel trimolecular mechanism of microbial attachment to mammalian host cells was characterized for the obligate intracellular pathogen Chlamydia trachomatis. Using purified glycosaminoglycans (GAGs) and specific GAG lyases, we demonstrated that a heparan sulfate-like GAG present on the surface of chlamydia organisms...

journal_title：Cell

authors： Zhang JP,Stephens RS

更新日期：1992-05-29 00:00:00

abstract：:Microtubule-dependent motor, murine KIF3B, was disrupted by gene targeting. The null mutants did not survive beyond midgestation, exhibiting growth retardation, pericardial sac ballooning, and neural tube disorganization. Prominently, the left-right asymmetry was randomized in the heart loop and the direction of embry...

journal_title：Cell

authors： Nonaka S,Tanaka Y,Okada Y,Takeda S,Harada A,Kanai Y,Kido M,Hirokawa N

更新日期：1998-12-11 00:00:00

abstract：:Netrins are bifunctional: they attract some axons and repel others. Netrin receptors of the Deleted in Colorectal Cancer (DCC) family are implicated in attraction and those of the UNC5 family in repulsion, but genetic evidence also suggests involvement of the DCC protein UNC-40 in some cases of repulsion. To test whet...

journal_title：Cell

authors： Hong K,Hinck L,Nishiyama M,Poo MM,Tessier-Lavigne M,Stein E

更新日期：1999-06-25 00:00:00

abstract：:The alpha IIb beta 3 integrin binds Arg-Gly-Asp-containing (RGD-containing) ligands in a cation-dependent interaction. A fourteen amino acid sequence, beta 3 (118-131), and an antibody to it, inhibited ligand binding functions of alpha IIb beta 3, and a 1:1 stoichiometric beta 3 (118-131)-RGD complex was detected by m...

journal_title：Cell

authors： D'Souza SE,Haas TA,Piotrowicz RS,Byers-Ward V,McGrath DE,Soule HR,Cierniewski C,Plow EF,Smith JW

更新日期：1994-11-18 00:00:00

abstract：:Here, we present a unifying hypothesis about how messenger RNAs, transcribed pseudogenes, and long noncoding RNAs "talk" to each other using microRNA response elements (MREs) as letters of a new language. We propose that this "competing endogenous RNA" (ceRNA) activity forms a large-scale regulatory network across the...

journal_title：Cell

authors： Salmena L,Poliseno L,Tay Y,Kats L,Pandolfi PP

更新日期：2011-08-05 00:00:00

abstract：:Membrane subdomains have been implicated in T cell signaling, although their properties and mechanisms of formation remain controversial. Here, we have used single-molecule and scanning confocal imaging to characterize the behavior of GFP-tagged signaling proteins in Jurkat T cells. We show that the coreceptor CD2, th...

journal_title：Cell

authors： Douglass AD,Vale RD

更新日期：2005-06-17 00:00:00