Abstract：
:Oligodendrocyte-specific protein (OSP)/claudin-11 is a recently identified transmembrane protein found in CNS myelin and testis with unknown function. Herein we demonstrate that Osp null mice exhibit both neurological and reproductive deficits: CNS nerve conduction is slowed, hindlimb weakness is conspicuous, and males are sterile. Freeze fracture reveals that tight junction intramembranous strands are absent in CNS myelin and between Sertoli cells of mutant mice. Our results demonstrate that OSP is the mediator of parallel-array tight junction strands and distinguishes this protein from other intrinsic membrane proteins in tight junctions. These novel results provide direct evidence of the pivotal role of the claudin family in generating the paracellular physical barrier of tight junctions necessary for spermatogenesis and normal CNS function.
journal_name
Celljournal_title
Cellauthors
Gow A,Southwood CM,Li JS,Pariali M,Riordan GP,Brodie SE,Danias J,Bronstein JM,Kachar B,Lazzarini RAdoi
10.1016/s0092-8674(00)81553-6subject
Has Abstractpub_date
1999-12-10 00:00:00pages
649-59issue
6eissn
0092-8674issn
1097-4172pii
S0092-8674(00)81553-6journal_volume
99pub_type
杂志文章相关文献
CELL文献大全abstract：:We have identified a yeast protein that binds specifically to the ARS consensus sequence. By two-step chromatography we have purified the factor to apparent homogeneity as a single polypeptide of 67 kd. The purified ARS consensus-binding protein (ACBP) recognizes the ARS consensus of the four genomic ARS elements test...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(91)90319-t
更新日期：1991-03-08 00:00:00
abstract：:The mitochondrial RNA binding proteins MRP1 and MRP2 form a heteromeric complex that functions in kinetoplastid RNA editing. In this process, MRP1/MRP2 serves as a matchmaker by binding to guide RNAs and facilitating their hybridization with cognate preedited mRNAs. To understand the mechanism by which this complex pe...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2006.06.047
更新日期：2006-08-25 00:00:00
abstract：:The brlA gene of A. nidulans mediates the developmental switch from the indeterminate, apical growth pattern of vegetative cells to the budding growth pattern of conidiophores. brlA encodes a 432 amino acid polypeptide containing two directly repeated motifs resembling the Zn(II) coordination sites first recognized in...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(88)90198-5
更新日期：1988-07-29 00:00:00
abstract：:Following TGFbeta receptor-mediated phosphorylation and association with Smad4, Smad2 moves into the nucleus, binds to target promoters in association with DNA-binding cofactors, and recruits coactivators such as p300/CBP to activate transcription. We identified the homeodomain protein TGIF as a Smad2-binding protein ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)80712-6
更新日期：1999-04-02 00:00:00
abstract：:Use-dependent synapse remodeling is thought to provide a cellular mechanism for encoding durable memories, yet whether activity triggers an actual structural change has remained controversial. We use photoconductive stimulation to demonstrate activity-dependent morphological synaptic plasticity by video imaging of GFP...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(01)00579-7
更新日期：2001-11-30 00:00:00
abstract：:Motile cells extend a leading edge by assembling a branched network of actin filaments that produces physical force as the polymers grow beneath the plasma membrane. A core set of proteins including actin, Arp2/3 complex, profilin, capping protein, and ADF/cofilin can reconstitute the process in vitro, and mathematica...
journal_title：Cell
pub_type： 杂志文章,评审
doi：10.1016/s0092-8674(03)00120-x
更新日期：2003-02-21 00:00:00
abstract：:Cyclic dinucleotides (CDNs) play central roles in bacterial pathogenesis and innate immunity. The mammalian enzyme cGAS synthesizes a unique cyclic dinucleotide (cGAMP) containing a 2'-5' phosphodiester linkage essential for optimal immune stimulation, but the molecular basis for linkage specificity is unknown. Here, ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2014.07.028
更新日期：2014-08-28 00:00:00
abstract：:Purified reovirus synthesizes in vitro a mixture of mRNA molecules that contain 5' terminal structures of the type ppG..., GpppG..., and m7GpppGm, the relative amount of each depending upon the presence of S-adenosylmethionine (SAM) or S-adenosylhomocysteine (SAH) in the transcription incubation mixture. Reovirus mRNA...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(75)90009-4
更新日期：1975-10-01 00:00:00
abstract：:Prolonged behavioral challenges can cause animals to switch from active to passive coping strategies to manage effort-expenditure during stress; such normally adaptive behavioral state transitions can become maladaptive in psychiatric disorders such as depression. The underlying neuronal dynamics and brainwide interac...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2019.02.037
更新日期：2019-05-02 00:00:00
abstract：:The genetics of complex disease produce alterations in the molecular interactions of cellular pathways whose collective effect may become clear through the organized structure of molecular networks. To characterize molecular systems associated with late-onset Alzheimer's disease (LOAD), we constructed gene-regulatory ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2013.03.030
更新日期：2013-04-25 00:00:00
abstract：:A recent report proposed a function of the ubiquitin conjugation factors Rad6 and Rad18 comparable to the bacterial SOS response, controlling damage-induced transcriptional activation and contributing to checkpoint signaling. The relevant ubiquitylation target was identified as budding yeast Rad17, a subunit of the PC...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2010.04.039
更新日期：2010-06-11 00:00:00
abstract：:Neurons in the cerebral cortex connect through descending pathways to hindbrain and spinal cord to activate muscle and generate movement. Although components of this pathway have been previously generated and studied in vitro, the assembly of this multi-synaptic circuit has not yet been achieved with human cells. Here...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2020.11.017
更新日期：2020-12-23 00:00:00
abstract：:Cell surface growth factor receptors couple environmental cues to the regulation of cytoplasmic homeostatic processes, including autophagy, and aberrant activation of such receptors is a common feature of human malignancies. Here, we defined the molecular basis by which the epidermal growth factor receptor (EGFR) tyro...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2013.08.015
更新日期：2013-09-12 00:00:00
abstract：:DNA double-strand breaks (DSBs) in B lymphocytes arise stochastically during replication or as a result of targeted DNA damage by activation-induced cytidine deaminase (AID). Here we identify recurrent, early replicating, and AID-independent DNA lesions, termed early replication fragile sites (ERFSs), by genome-wide l...
journal_title：Cell
pub_type： 杂志文章,评审
doi：10.1016/j.cell.2013.01.006
更新日期：2013-01-31 00:00:00
abstract：:GAL4 derivatives containing an activation domain alleviated repression of a promoter during nucleosome assembly. A GAL4 derivative lacking an activation domain stably bound the promoter during nucleosome assembly but was not sufficient to preserve promoter function. The activation domain of GAL4 derivatives was essent...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(91)90237-s
更新日期：1991-02-08 00:00:00
abstract：:Glucose homeostasis is strictly controlled in all domains of life. Bacteria that are unable to balance intracellular sugar levels and deal with potentially toxic phosphosugars cease growth and risk being outcompeted. Here, we identify the conserved haloacid dehalogenase (HAD)-like enzyme YigL as the previously hypothe...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2013.03.003
更新日期：2013-04-11 00:00:00
abstract：:The mammalian alpha- and beta--globin genes are thought to have evolved from a common ancestral sequence by a duplication event that occurred over 500 million years ago. We have now determined the entire nucleotide sequence of a cloned mouse alpha--globin gene, including regions that flank and interrupt the coding seq...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(79)90139-9
更新日期：1979-11-01 00:00:00
abstract：:Loss of cell cycle control and acquisition of chromosomal rearrangements such as gene amplification often occur during tumor progression, suggesting that they may be correlated. We show here that the wild-type p53 allele is lost when fibroblasts from patients with the Li-Fraumeni syndrome (LFS) are passaged in vitro. ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(92)90244-7
更新日期：1992-09-18 00:00:00
abstract：:Genomic Xenopus borealis oocyte-specific 5S DNA (Xbo) contains clusters of 5S rRNA genes. The number of genes varies among clusters, and the distance between genes within a cluster is about 80 nucleotides. The spacer DNA between gene clusters is AT-rich and heterogeneous in length due in part to variable numbers of a ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(78)90042-9
更新日期：1978-12-01 00:00:00
abstract：:The DNA-binding region of Myb consists of three imperfect tandem repeats (R1, R2, and R3). We have determined the solution structure of a specific DNA complex of the minimum DNA-binding domain (R2R3) by heteronuclear multidimensional NMR. Both R2 and R3 contain three helices, and the third helix in each is found to be...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(94)90549-5
更新日期：1994-11-18 00:00:00
abstract：:Leukocyte adhesion deficiency (LAD) is a heritable disease involving deficient expression of three related leukocyte adhesion glycoproteins: LFA-1, Mac-1, and p150,95. These proteins are alpha beta heterodimers containing identical 95,000 dalton beta subunits. Here we demonstrate that the primary defect in LAD is in t...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(87)90215-7
更新日期：1987-07-17 00:00:00
abstract：:Acquisition of the intestinal microbiota begins at birth, and a stable microbial community develops from a succession of key organisms. Disruption of the microbiota during maturation by low-dose antibiotic exposure can alter host metabolism and adiposity. We now show that low-dose penicillin (LDP), delivered from birt...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2014.05.052
更新日期：2014-08-14 00:00:00
abstract：:The mTOR Complex 1 (mTORC1) pathway regulates cell growth in response to numerous cues, including amino acids, which promote mTORC1 translocation to the lysosomal surface, its site of activation. The heterodimeric RagA/B-RagC/D GTPases, the Ragulator complex that tethers the Rags to the lysosome, and the v-ATPase form...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2012.07.032
更新日期：2012-09-14 00:00:00
abstract：:Cancer cells have distinctive nutrient demands to fuel growth and proliferation, including the disproportionate use of glucose, glutamine, and fatty acids. Comerford et al. and Mashimo et al. now demonstrate that several types of cancer are avid consumers of acetate, which facilitates macromolecular biosynthesis and h...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2014.12.009
更新日期：2014-12-18 00:00:00
abstract：:The role of the noncoding genome in cancer biology is continually expanding. Cho et al. reveal a new and unexpected mechanism for the regulation of MYC expression mediated by the promoter sequence of its neighbor gene PVT1. This DNA element acts as a promoter-enhancer competitor and a candidate tumor suppressor. ...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2018.05.023
更新日期：2018-05-31 00:00:00
abstract：:PTEN is a frequently mutated tumor suppressor gene that opposes the PI3K/AKT pathway through dephosphorylation of phosphoinositide-3,4,5-triphosphate. Recently, nuclear compartmentalization of PTEN was found as a key component of its tumor-suppressive activity; however its nuclear function remains poorly defined. Here...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2010.12.020
更新日期：2011-01-21 00:00:00
abstract：:Genetic alterations in signaling pathways that control cell-cycle progression, apoptosis, and cell growth are common hallmarks of cancer, but the extent, mechanisms, and co-occurrence of alterations in these pathways differ between individual tumors and tumor types. Using mutations, copy-number changes, mRNA expressio...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2018.03.035
更新日期：2018-04-05 00:00:00
abstract：:The somatic 5S DNA from X. borealis (Xbs 5S DNA) and X. laevis (Xis 5S DNA) and a minor oocyte-specific 5S DNA from X. laevis (Xit 5S DNA) have been purified, and individual repeating units have been cloned and sequenced. The two somatic 5S DNAs differ from the major oocyte 5S DNAs in having GC-rich spacers, homogeneo...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(80)90241-x
更新日期：1980-05-01 00:00:00
abstract：:This year's Lasker-Bloomberg Public Service Award goes to GAVI, the Vaccine Alliance, for providing sustained access to childhood vaccines around the globe, saving millions of lives, and highlighting the power of immunization to prevent disease. ...
journal_title：Cell
pub_type： 历史文章,杂志文章
doi：10.1016/j.cell.2019.08.026
更新日期：2019-09-19 00:00:00
abstract：:Striated muscle-specific disruption of the dystroglycan (DAG1) gene results in loss of the dystrophin-glycoprotein complex in differentiated muscle and a remarkably mild muscular dystrophy with hypertrophy and without tissue fibrosis. We find that satellite cells, expressing dystroglycan, support continued efficient r...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(02)00907-8
更新日期：2002-09-06 00:00:00
