Abstract：
:Members of the E2F transcription factor family (E2F-1-E2F-5) are believed to be critical positive regulators of cell cycle progression in eukaryotes although the in vivo functions of the individual E2Fs have not been elucidated. Mice were generated that lack E2F-1 and, surprisingly, these mice develop and reproduce normally. However, E2F-1-/- mice exhibit a defect in T lymphocyte development leading to an excess of mature T cells due to a maturation stage-specific defect in thymocyte apoptosis. As E2F-1-/- mice age they exhibit a second phenotype marked by aberrant cell proliferation. These findings suggest that while certain members of the E2F family may positively regulate cell cycle progression, E2F-1 functions to regulate apoptosis and to suppress cell proliferation.
journal_name
Celljournal_title
Cellauthors
Field SJ,Tsai FY,Kuo F,Zubiaga AM,Kaelin WG Jr,Livingston DM,Orkin SH,Greenberg MEdoi
10.1016/s0092-8674(00)81255-6subject
Has Abstractpub_date
1996-05-17 00:00:00pages
549-61issue
4eissn
0092-8674issn
1097-4172pii
S0092-8674(00)81255-6journal_volume
85pub_type
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