Abstract：
:By chromosome walking in the major histocompatibility complex (MHC) of the BALB/c mouse, we have linked the K region to the I region at the molecular level. Forty-nine overlapping cosmid clones define a stretch of about 600 kb of DNA containing 2 class I and 7 class II genes. Eleven independent recombination events were mapped between the K and the I region marker loci by Southern blot analysis of polymorphic restriction sites. Eight of these events involved crossing-over, at an unusually high frequency of 0.6%-1.5% between genes from Mus musculus castaneus and laboratory mouse strains, and they were confined to two small stretches of DNA. We conclude that recombination hotspots are present at these positions in the two M.m. castaneus MHC haplotypes tested. In contrast, several MHC haplotypes of laboratory mice appear to lack those hotspots.
journal_name
Celljournal_title
Cellauthors
Steinmetz M,Stephan D,Fischer Lindahl Kdoi
10.1016/0092-8674(86)90012-7subject
Has Abstractpub_date
1986-03-28 00:00:00pages
895-904issue
6eissn
0092-8674issn
1097-4172pii
0092-8674(86)90012-7journal_volume
44pub_type
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