Abstract：
:Dietary soluble fibers are fermented by gut bacteria into short-chain fatty acids (SCFA), which are considered broadly health-promoting. Accordingly, consumption of such fibers ameliorates metabolic syndrome. However, incorporating soluble fiber inulin, but not insoluble fiber, into a compositionally defined diet, induced icteric hepatocellular carcinoma (HCC). Such HCC was microbiota-dependent and observed in multiple strains of dysbiotic mice but not in germ-free nor antibiotics-treated mice. Furthermore, consumption of an inulin-enriched high-fat diet induced both dysbiosis and HCC in wild-type (WT) mice. Inulin-induced HCC progressed via early onset of cholestasis, hepatocyte death, followed by neutrophilic inflammation in liver. Pharmacologic inhibition of fermentation or depletion of fermenting bacteria markedly reduced intestinal SCFA and prevented HCC. Intervening with cholestyramine to prevent reabsorption of bile acids also conferred protection against such HCC. Thus, its benefits notwithstanding, enrichment of foods with fermentable fiber should be approached with great caution as it may increase risk of HCC.
journal_name
Celljournal_title
Cellauthors
Singh V,Yeoh BS,Chassaing B,Xiao X,Saha P,Aguilera Olvera R,Lapek JD Jr,Zhang L,Wang WB,Hao S,Flythe MD,Gonzalez DJ,Cani PD,Conejo-Garcia JR,Xiong N,Kennett MJ,Joe B,Patterson AD,Gewirtz AT,Vijay-Kumar Mdoi
10.1016/j.cell.2018.09.004subject
Has Abstractpub_date
2018-10-18 00:00:00pages
679-694.e22issue
3eissn
0092-8674issn
1097-4172pii
S0092-8674(18)31176-0journal_volume
175pub_type
杂志文章相关文献
CELL文献大全abstract：:The brlA gene of A. nidulans mediates the developmental switch from the indeterminate, apical growth pattern of vegetative cells to the budding growth pattern of conidiophores. brlA encodes a 432 amino acid polypeptide containing two directly repeated motifs resembling the Zn(II) coordination sites first recognized in...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(88)90198-5
更新日期：1988-07-29 00:00:00
abstract：:The segment polarity genes engrailed and wingless are expressed in neighboring stripes of cells on opposite sides of the Drosophila parasegment boundary. Each gene is mutually required for maintenance of the other's expression; continued expression of both also requires several other segment polarity genes. We show he...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(92)90264-d
更新日期：1992-10-02 00:00:00
abstract：:A mutant in src, the oncogene of Rous sarcoma virus, has been constructed in which the major phosphorylated tyrosine (Tyr-416, located in the carboxy-terminal half of the protein) has been replaced by phenylalanine. Mouse cells transformed with this mutant src form foci and grow in soft agar, indicative of a transform...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(83)90074-0
更新日期：1983-03-01 00:00:00
abstract：:Polycomb group (PcG) proteins form large multimeric complexes (PcG bodies) which are involved in the stable repression of gene expression. The human PcG protein, Pc2, has been shown to recruit the transcriptional corepressor, CtBP, to PcG bodies. We show that CtBP is sumoylated at a single lysine. In vitro, CtBP sumoy...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(03)00159-4
更新日期：2003-04-04 00:00:00
abstract：:Endophytic fungi are found within the roots of healthy plants, but their function is poorly understood. In this issue, Hiruma et al. demonstrate that, under phosphate-limiting conditions, the endophytic fungus, Colletotrichum tofieldiae, provides growth-promoting and fitness benefits to Arabidopsis, but the plant must...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2016.03.036
更新日期：2016-04-07 00:00:00
abstract：:We have isolated the bovine and human genes for Müllerian inhibiting substance (MIS), a testicular glycoprotein that causes regression of the Müllerian duct during development of the male embryo. The mRNA sequence of bovine MIS, determined from an analysis of cDNA and genomic clones, codes for a protein of 575 amino a...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(86)90783-x
更新日期：1986-06-06 00:00:00
abstract：:The general transcription factor TFIID is a multiprotein complex containing the TATA-binding protein and several associated factors (TAFs), some of which may function as coactivators that are essential for activated, but not basal, transcription. Here we describe the isolation and characterization of the first gene en...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(93)90664-c
更新日期：1993-01-29 00:00:00
abstract：:The COVID-19 pandemic urgently needs therapeutic and prophylactic interventions. Here, we report the rapid identification of SARS-CoV-2-neutralizing antibodies by high-throughput single-cell RNA and VDJ sequencing of antigen-enriched B cells from 60 convalescent patients. From 8,558 antigen-binding IgG1+ clonotypes, 1...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2020.05.025
更新日期：2020-07-09 00:00:00
abstract：:Understanding how transcriptional enhancers control over 20,000 protein-coding genes to maintain cell-type-specific gene expression programs in all human cells is a fundamental challenge in regulatory biology. Recent studies suggest that gene regulatory elements and their target genes generally occur within insulated ...
journal_title：Cell
pub_type： 杂志文章,评审
doi：10.1016/j.cell.2016.10.024
更新日期：2016-11-17 00:00:00
abstract：:We have isolated spontaneous temperature-resistant revertants of a temperature-sensitive mutation (rpoD800) in the sigma subunit of E. coli K12 RNA polymerase. These revertants still contained the rpoD800 allele. They were mucoid, and sensitive to ultraviolet light and the radiomimetic agent nitrofurantoin, which are ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(83)90505-6
更新日期：1983-01-01 00:00:00
abstract：:Thrombin stimulates 32Pi incorporation into phosphatidylinositol 4-phosphate (PIP), phosphatidylinositol 4,5-bis-phosphate (PIP2), and phosphatidylinositol (PI), and initiates DNA synthesis in hamster (NIL) fibroblasts at a half-maximal concentration of 125 ng/ml. Neomycin, which binds PIP2 and PIP, inhibits both thro...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(85)90105-9
更新日期：1985-09-01 00:00:00
abstract：:There is tremendous enthusiasm for the microbiome in academia and industry. This Perspective argues that in order to realize its potential, the field needs to focus on establishing causation and molecular mechanism with an emphasis on phenotypes that are large in magnitude, easy to measure, and unambiguously driven by...
journal_title：Cell
pub_type： 杂志文章,评审
doi：10.1016/j.cell.2018.07.038
更新日期：2018-08-09 00:00:00
abstract：:Mutations in the Drosophila maternal genes plutonium (plu) and pan gu (png) have the striking phenotype that DNA replication initiates in unfertilized eggs. Fertilized eggs from plu or png mutant mothers also have a mutant phenotype; DNA replication is uncoupled from nuclear division, resulting in giant, polyploid nuc...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(91)90050-9
更新日期：1991-09-20 00:00:00
abstract：:Biomechanical stress is a major stimulus for cardiac hypertrophy and the transition to heart failure. By generating mice that harbor a ventricular restricted knockout of the gp130 cytokine receptor via Cre-IoxP-mediated recombination, we demonstrate a critical role for a gp130-dependent myocyte survival pathway in the...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)80729-1
更新日期：1999-04-16 00:00:00
abstract：:Telomeres are specialized protein-DNA complexes that compose the ends of eukaryotic chromosomes. Telomeres protect chromosome termini from degradation and recombination and act together with telomerase to ensure complete genome replication. We have determined the crystal structure of the two-subunit Oxytricha nova tel...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)81720-1
更新日期：1998-12-23 00:00:00
abstract：:Receptor-interacting protein kinase (RIPK)-1 is involved in RIPK3-dependent and -independent signaling pathways leading to cell death and/or inflammation. Genetic ablation of ripk1 causes postnatal lethality, which was not prevented by deletion of ripk3, caspase-8, or fadd. However, animals that lack RIPK1, RIPK3, and...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2014.04.018
更新日期：2014-05-22 00:00:00
abstract：:Complex gene regulatory networks require transcription factors (TFs) to bind distinct DNA sequences. To understand how novel TF specificity evolves, we combined phylogenetic, biochemical, and biophysical approaches to interrogate how DNA recognition diversified in the steroid hormone receptor (SR) family. After duplic...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2014.09.003
更新日期：2014-09-25 00:00:00
abstract：:Phosphoinositide 3 kinase (PI3K) is a key signaling enzyme implicated in receptor-stimulated mitogenesis, oxidative bursting in neutrophils, membrane ruffling, and glucose uptake. A PI3K has already been purified, cloned, and shown to be regulated by receptors that act via tyrosine kinase-dependent regulatory mechanis...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(94)90237-2
更新日期：1994-04-08 00:00:00
abstract：:The difficulty in identifying ligands for nuclear hormone receptors remains an obstacle to understanding their function. For example, in the fruit fly Drosophila melanogaster, only one of its nuclear receptors has a known ligand. In this issue of Cell, report that the fruit fly E75 nuclear receptor contains heme in it...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2005.07.007
更新日期：2005-07-29 00:00:00
abstract：:A major challenge to understanding how cells work together in the central nervous system (CNS) is the heterogeneous cellular composition of the brain. In this issue, Heiman et al. (2008) and Doyle et al. (2008) introduce a new strategy (TRAP) that enables the profiling of translated mRNAs in specific CNS cell populati...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2008.10.031
更新日期：2008-11-14 00:00:00
abstract：:Gram-negative bacteria have an outer membrane (OM) that functions as a barrier to protect the cell from toxic compounds such as antibiotics and detergents. The OM is a highly asymmetric bilayer composed of phospholipids, glycolipids, and proteins. Assembly of this essential organelle occurs outside the cytoplasm in an...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2005.02.015
更新日期：2005-04-22 00:00:00
abstract：:Clarification of the information processing system in bacterial sensing has been obtained by studying mutants that lack the capacity to modify receptors covalently. The remaining part of the system is able to receive signals from the receptor, to respond with partial adaptation, and to exhibit a chemotactic response. ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(85)90125-4
更新日期：1985-09-01 00:00:00
abstract：:This year, the Lasker∼DeBakey Clinical Medical Research Award will be shared by Mahlon R. DeLong and Alim-Louis Benabid for elucidating the role of the subthalamic nucleus in mediating the motor dysfunction of Parkinson's disease and for pioneering the use of deep-brain stimulation to alleviate symptoms of the disease...
journal_title：Cell
pub_type： 传,历史文章,杂志文章
doi：10.1016/j.cell.2014.08.021
更新日期：2014-09-11 00:00:00
abstract：:Apoptosis and autophagy are both tightly regulated biological processes that play a central role in tissue homeostasis, development, and disease. The anti-apoptotic protein, Bcl-2, interacts with the evolutionarily conserved autophagy protein, Beclin 1. However, little is known about the functional significance of thi...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2005.07.002
更新日期：2005-09-23 00:00:00
abstract：:Replicative intermediates of SV40 were isolated, digested with the restriction endonuclease Bgl I and examined by electron microscopy. Over 98% of the replicative intermediates isolated following infection with wild-type virions at 33 degrees, 37 degrees or 40 degrees C or with tsA209 at 33 degrees C had initiated rep...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(80)90624-8
更新日期：1980-06-01 00:00:00
abstract：:Pulmonary neuroendocrine (NE) cells are neurosensory cells sparsely distributed throughout the bronchial epithelium, many in innervated clusters of 20-30 cells. Following lung injury, NE cells proliferate and generate other cell types to promote epithelial repair. Here, we show that only rare NE cells, typically 2-4 p...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2019.09.010
更新日期：2019-10-03 00:00:00
abstract：:Here we characterize the T-cell-activating protein (TAP), an Ly-6 gene product involved in T cell activation, as a glycoprotein with a molecular weight of 10-12 kd under nonreducing conditions and 15-18 kd under reducing ones. Two of the three bands that are precipitated from metabolically labeled cells are expressed ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(86)90593-3
更新日期：1986-11-07 00:00:00
abstract：:A cDNA library has been constructed from an RNA preparation highly enriched in silkmoth chorion mRNAs. Many distinct clones have been identified from this library using a stepwise procedure: scoring for infrequent hexanucleotide restriction enzyme recognition sequences; detailed characterization with restriction enzym...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(79)90241-1
更新日期：1979-12-01 00:00:00
abstract：:The majority of the mRNA molecules in HeLa cells contain 1-2 residue(s) of m6Ap and one blocked, methylated 5' terminal "cap" structure. The hnRNA, which is longer than mRNA, contains both m6Ap and caps but 4-6 times as many m6Ap residues per chain. In addition, nuclear molecules contain T2 RNA ase-resistant, methyl-l...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(76)90022-2
更新日期：1976-02-01 00:00:00
abstract：:AU-rich elements (AREs), present in mRNA 3'-UTRs, are potent posttranscriptional regulatory signals that can rapidly effect changes in mRNA stability and translation, thereby dramatically altering gene expression with clinical and developmental consequences. In human cell lines, the TNFalpha ARE enhances translation r...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2007.01.038
更新日期：2007-03-23 00:00:00
