brlA is necessary and sufficient to direct conidiophore development in Aspergillus nidulans.

Abstract:

:The brlA gene of A. nidulans mediates the developmental switch from the indeterminate, apical growth pattern of vegetative cells to the budding growth pattern of conidiophores. brlA encodes a 432 amino acid polypeptide containing two directly repeated motifs resembling the Zn(II) coordination sites first recognized in Xenopus TFIIIA. Misscheduled expression of brlA in vegetative cells results in transcriptional activation of developmentally regulated genes, cessation of unidirectional hyphal growth, initiation of cellular transformations resembling those that occur during normal conidiophore development, and production of viable conidiospores. We propose that BRLA is a nucleic acid-binding protein whose expression in vegetative cells is sufficient to induce sporulation through its role in regulating expression of conidiation-specific genes.

journal_name

Cell

journal_title

Cell

authors

Adams TH,Boylan MT,Timberlake WE

doi

10.1016/0092-8674(88)90198-5

subject

Has Abstract

pub_date

1988-07-29 00:00:00

pages

353-62

issue

3

eissn

0092-8674

issn

1097-4172

pii

0092-8674(88)90198-5

journal_volume

54

pub_type

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