S. cerevisiae chromosomes biorient via gradual resolution of syntely between S phase and anaphase.

abstract：:The crystal structure of a proteolytic subfragment from scallop striated muscle myosin, complexed with MgADP, has been solved at 2.5 A resolution and reveals an unusual conformation of the myosin head. The converter and the lever arm are in very different positions from those in either the pre-power stroke or near-rig...

journal_title：Cell

authors： Houdusse A,Kalabokis VN,Himmel D,Szent-Györgyi AG,Cohen C

更新日期：1999-05-14 00:00:00

abstract：:Prions have been responsible for an entire century of tragic episodes. Fifty years ago, kuru decimated the population of Papua New Guinea. Then, iatrogenic transmission of prions caused more than 250 cases of Creutzfeldt-Jakob disease. More recently, transmission of bovine spongiform encephalopathy to humans caused a ...

journal_title：Cell

authors： Aguzzi A,Polymenidou M

更新日期：2004-01-23 00:00:00

abstract：:HIV release requires TSG101, a cellular factor that sorts proteins into vesicles that bud into multivesicular bodies (MVB). To test whether other proteins involved in MVB biogenesis (the class E proteins) also participate in HIV release, we identified 22 candidate human class E proteins. These proteins were connected ...

journal_title：Cell

authors： von Schwedler UK,Stuchell M,Müller B,Ward DM,Chung HY,Morita E,Wang HE,Davis T,He GP,Cimbora DM,Scott A,Kräusslich HG,Kaplan J,Morham SG,Sundquist WI

更新日期：2003-09-19 00:00:00

abstract：:VopL is an effector protein from Vibrio parahaemolyticus that nucleates actin filaments. VopL consists of a VopL C-terminal domain (VCD) and an array of three WASP homology 2 (WH2) motifs. Here, we report the crystal structure of the VCD dimer bound to actin. The VCD organizes three actin monomers in a spatial arrange...

journal_title：Cell

authors： Zahm JA,Padrick SB,Chen Z,Pak CW,Yunus AA,Henry L,Tomchick DR,Chen Z,Rosen MK

更新日期：2013-10-10 00:00:00

abstract：:Many body surfaces harbor organ-specific γδ T cell compartments that contribute to tissue integrity. Thus, murine dendritic epidermal T cells (DETCs) uniquely expressing T cell receptor (TCR)-Vγ5 chains protect from cutaneous carcinogens. The DETC repertoire is shaped by Skint1, a butyrophilin-like (Btnl) gene express...

journal_title：Cell

authors： Di Marco Barros R,Roberts NA,Dart RJ,Vantourout P,Jandke A,Nussbaumer O,Deban L,Cipolat S,Hart R,Iannitto ML,Laing A,Spencer-Dene B,East P,Gibbons D,Irving PM,Pereira P,Steinhoff U,Hayday A

更新日期：2016-09-22 00:00:00

abstract：:A clone encoding PrP 27-30, the major protein in purified preparations of scrapie agent, was selected from a scrapie-infected hamster brain cDNA library by oligonucleotide probes corresponding to the N terminus of the protein. Southern blotting with PrP cDNA revealed a single gene with the same restriction patterns in...

journal_title：Cell

authors： Oesch B,Westaway D,Wälchli M,McKinley MP,Kent SB,Aebersold R,Barry RA,Tempst P,Teplow DB,Hood LE

更新日期：1985-04-01 00:00:00

abstract：:To relate different forms of synaptic plasticity to the formation and maintenance of place cells in the hippocampus, we have recorded place cells in freely behaving, transgenic mice that express a mutated Ca2+-independent form of CaM Kinase II. These mice have normal long-term potentiation (LTP) at 100 Hz, but they la...

journal_title：Cell

authors： Rotenberg A,Mayford M,Hawkins RD,Kandel ER,Muller RU

更新日期：1996-12-27 00:00:00

abstract：:Notch signaling is a key developmental pathway that is subject to frequent genetic and epigenetic perturbations in many different human tumors. Here we investigate whether long noncoding RNA (lncRNA) genes, in addition to mRNAs, are key downstream targets of oncogenic Notch1 in human T cell acute lymphoblastic leukemi...

journal_title：Cell

authors： Trimarchi T,Bilal E,Ntziachristos P,Fabbri G,Dalla-Favera R,Tsirigos A,Aifantis I

更新日期：2014-07-31 00:00:00

abstract：:Anterograde transport in the early secretory pathway is mediated by COPII-coated vesicles. Stagg et al. (2008) have now visualized the double-layered COPII coat using electron cryomicroscopy, providing insight into how coats are assembled to accommodate cargo of different sizes. ...

journal_title：Cell

authors： Hughson FM

更新日期：2008-08-08 00:00:00

abstract：:Dot1 is an evolutionarily conserved histone methyltransferase that methylates lysine-79 of histone H3 in the core domain. Unlike other histone methyltransferases, Dot1 does not contain a SET domain, and it specifically methylates nucleosomal histone H3. We have solved a 2.5 A resolution structure of the catalytic doma...

journal_title：Cell

authors： Min J,Feng Q,Li Z,Zhang Y,Xu RM

更新日期：2003-03-07 00:00:00

abstract：:Phosphoinositide 3 kinase (PI3K) is a key signaling enzyme implicated in receptor-stimulated mitogenesis, oxidative bursting in neutrophils, membrane ruffling, and glucose uptake. A PI3K has already been purified, cloned, and shown to be regulated by receptors that act via tyrosine kinase-dependent regulatory mechanis...

journal_title：Cell

authors： Stephens L,Smrcka A,Cooke FT,Jackson TR,Sternweis PC,Hawkins PT

更新日期：1994-04-08 00:00:00

abstract：:We find that inactivation of a Drosophila homolog of the tumor suppressor APC (D-APC) causes retinal neuronal degeneration and pigment cell hypertrophy, a phenotype remarkably similar to that found in humans with germline APC mutations. Retinal degeneration in the D-APC mutant results from apoptotic cell death, which ...

journal_title：Cell

authors： Ahmed Y,Hayashi S,Levine A,Wieschaus E

更新日期：1998-06-26 00:00:00

abstract：:Reactivation of human cytomegalovirus (HCMV) results in severe disease in AIDS patients and immunocompromised patients receiving blood transfusions or organ or bone marrow grafts. Although the site of HCMV latency is unknown, blood cells have been implicated as a viral reservoir. In this study, we demonstrate HCMV rea...

journal_title：Cell

authors： Söderberg-Nauclér C,Fish KN,Nelson JA

更新日期：1997-10-03 00:00:00

abstract：:We have generated mice carrying a germline mutation in the tyrosine kinase catalytic domain of the trkB gene. This mutation eliminates expression of gp145trkB, a protein-tyrosine kinase that serves as the signaling receptor for two members of the nerve growth factor family of neurotrophins, brain-derived neurotrophic ...

journal_title：Cell

authors： Klein R,Smeyne RJ,Wurst W,Long LK,Auerbach BA,Joyner AL,Barbacid M

更新日期：1993-10-08 00:00:00

abstract：:The Viviparous-1 (Vp1) gene of maize is specifically required for expression of the maturation program in seed development. We show that Vp1 encodes a 73,335 dalton protein with no detectable homology to known proteins. An acidic transcriptional activation sequence was identified by fusion to the GAL4 DNA-binding doma...

journal_title：Cell

authors： McCarty DR,Hattori T,Carson CB,Vasil V,Lazar M,Vasil IK

更新日期：1991-09-06 00:00:00

abstract：:The bHLH-ZIP protein Mad heterodimerizes with Max as a sequence-specific transcriptional repressor. Mad is rapidly induced upon differentiation, and the associated switch from Myc-Max to Mad-Max heterocomplexes seem to repress genes normally activated by Myc-Max. We have identified two related mammalian cDNAs that enc...

journal_title：Cell

authors： Ayer DE,Lawrence QA,Eisenman RN

更新日期：1995-03-10 00:00:00

abstract：:Loss of cell cycle control and acquisition of chromosomal rearrangements such as gene amplification often occur during tumor progression, suggesting that they may be correlated. We show here that the wild-type p53 allele is lost when fibroblasts from patients with the Li-Fraumeni syndrome (LFS) are passaged in vitro. ...

journal_title：Cell

authors： Yin Y,Tainsky MA,Bischoff FZ,Strong LC,Wahl GM

更新日期：1992-09-18 00:00:00

abstract：:The V(D)J recombinase subunits Rag-1 and Rag-2 mediate assembly of antigen receptor gene segments. We studied the mechanisms of DNA recognition by Rag-1/Rag-2 using surface plasmon resonance. The critical step for signal recognition is binding of Rag-1 to the nonamer. This is achieved by a region of Rag-1 homologous t...

journal_title：Cell

authors： Spanopoulou E,Zaitseva F,Wang FH,Santagata S,Baltimore D,Panayotou G

更新日期：1996-10-18 00:00:00

abstract：:The Drosha-DGCR8 complex, also known as Microprocessor, is essential for microRNA (miRNA) maturation. Drosha functions as the catalytic subunit, while DGCR8 (also known as Pasha) recognizes the RNA substrate. Although the action mechanism of this complex has been intensively studied, it remains unclear how Drosha and ...

journal_title：Cell

authors： Han J,Pedersen JS,Kwon SC,Belair CD,Kim YK,Yeom KH,Yang WY,Haussler D,Blelloch R,Kim VN

更新日期：2009-01-09 00:00:00

abstract：:Type III secretion systems mediate export of virulence proteins and flagellar assembly subunits in Gram-negative bacteria. Chaperones specific to each class of secreted protein are believed to prevent degradation of the secreted substrates. We show that an additional role of chaperones may be to regulate translation o...

journal_title：Cell

authors： Karlinsey JE,Lonner J,Brown KL,Hughes KT

更新日期：2000-08-18 00:00:00

abstract：:Multisite hyperphosphorylation of tau has been implicated in the pathogenesis of neurodegenerative diseases including Alzheimer's disease (AD). However, the phosphorylation events critical for tau toxicity and mechanisms regulating these events are largely unknown. Here we show that Drosophila PAR-1 kinase initiates t...

journal_title：Cell

authors： Nishimura I,Yang Y,Lu B

更新日期：2004-03-05 00:00:00

abstract：:Gastrulation is a complex process requiring the coordination of cell shape changes and cell movements. In Drosophila, gastrulation begins immediately upon cellularization of the blastoderm stage embryo with the formation of the ventral furrow and posterior midgut. Cells that form both of these invaginations change the...

journal_title：Cell

authors： Parks S,Wieschaus E

更新日期：1991-01-25 00:00:00

abstract：:To guide the design of immunotherapy strategies for patients with early stage lung tumors, we developed a multiscale immune profiling strategy to map the immune landscape of early lung adenocarcinoma lesions to search for tumor-driven immune changes. Utilizing a barcoding method that allows a simultaneous single-cell ...

journal_title：Cell

authors： Lavin Y,Kobayashi S,Leader A,Amir ED,Elefant N,Bigenwald C,Remark R,Sweeney R,Becker CD,Levine JH,Meinhof K,Chow A,Kim-Shulze S,Wolf A,Medaglia C,Li H,Rytlewski JA,Emerson RO,Solovyov A,Greenbaum BD,Sanders C,Vi

更新日期：2017-05-04 00:00:00

abstract：:From the approximately 1,200 odorant receptor (OR) genes in the mouse genome, an olfactory sensory neuron is thought to express only one gene. The mechanisms of OR gene choice are not understood. A 2.1 kilobase region (the H element) adjacent to a cluster of seven OR genes has been proposed as a trans- and pan-enhance...

journal_title：Cell

authors： Fuss SH,Omura M,Mombaerts P

更新日期：2007-07-27 00:00:00

abstract：:We have isolated the genes encoding the largest subunit of all three classes of RNA polymerase from Trypanosoma brucei. While the pol II largest subunit is encoded by a single gene in all organisms examined to date, trypanosomes contain two copies of the gene. Both genes are expressed in the procyclic and bloodstream ...

journal_title：Cell

authors： Smith JL,Levin JR,Ingles CJ,Agabian N

更新日期：1989-03-10 00:00:00

abstract：:Spatial organization of cellular proteins plays an important role in establishment of cellular polarity to regulate cell division, differentiation, migration, and organogenesis. Activation of T cells by antigen-presenting cells (APCs) results in the formation of an immunological synapse (IS), assembly of a signaling s...

journal_title：Cell

authors： Yeh JH,Sidhu SS,Chan AC

更新日期：2008-03-07 00:00:00

abstract：:Tissue homeostasis requires maintenance of functional integrity under stress. A central source of stress is mechanical force that acts on cells, their nuclei, and chromatin, but how the genome is protected against mechanical stress is unclear. We show that mechanical stretch deforms the nucleus, which cells initially ...

journal_title：Cell

authors： Nava MM,Miroshnikova YA,Biggs LC,Whitefield DB,Metge F,Boucas J,Vihinen H,Jokitalo E,Li X,García Arcos JM,Hoffmann B,Merkel R,Niessen CM,Dahl KN,Wickström SA

更新日期：2020-05-14 00:00:00

abstract：:The retinoblastoma tumor suppressor protein (RB) binds several cellular proteins involved in cell cycle progression. Using the yeast two-hybrid system, we found that RB bound specifically to the protein BRG1. BRG1 shares extensive sequence similarity to Drosophila brahma, an activator of homeotic gene expression, and ...

journal_title：Cell

authors： Dunaief JL,Strober BE,Guha S,Khavari PA,Alin K,Luban J,Begemann M,Crabtree GR,Goff SP

更新日期：1994-10-07 00:00:00

abstract：:A second and minor DNA component containing 5s RNA genes has been purified from the genomic DNA of Xenopus laevis (XIt 5S DNA). Some of its physical and chemical characteristics are described. It contains a 5S RNA gene sequence which has some oocyte and some somatic-specific residues, as well as nucleotides which diff...

journal_title：Cell

authors： Brown DD,Carrol D,Brown RD

更新日期：1977-12-01 00:00:00

abstract：:Interneurons in the neocortex of the brain are small, locally projecting inhibitory GABAergic cells with a broad array of anatomical and physiological properties. The diversity of interneurons is believed to be crucial for regulating myriad operations in the neocortex. Here, we describe current theories about how inte...

journal_title：Cell

authors： Moore CI,Carlen M,Knoblich U,Cardin JA

更新日期：2010-07-23 00:00:00