Abstract：
:Filamentous invasive growth of S. cerevisiae requires multiple elements of the mitogen-activated protein kinase (MAPK) signaling cascade that are also components of the mating pheromone response pathway. Here we show that, despite sharing several constituents, the two pathways use different MAP kinases. The Fus3 MAPK regulates mating, whereas the Kss1 MAPK regulates filamentation and invasion. Remarkably, in addition to their kinase-dependent activation functions, Kss1 and Fus3 each have a distinct kinase-independent inhibitory function. Kss1 inhibits the filamentation pathway by interacting with its target transcription factor Ste12. Fus3 has a different inhibitory activity that prevents the inappropriate activation of invasion by the pheromone response pathway. In the absence of Fus3, there is erroneous crosstalk in which mating pheromone now activates filamentation-specific gene expression using the Kss1 MAPK.
journal_name
Celljournal_title
Cellauthors
Madhani HD,Styles CA,Fink GRdoi
10.1016/s0092-8674(00)80454-7subject
Has Abstractpub_date
1997-11-28 00:00:00pages
673-84issue
5eissn
0092-8674issn
1097-4172pii
S0092-8674(00)80454-7journal_volume
91pub_type
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