Abstract：
:We predict regulatory targets for 14 Arabidopsis microRNAs (miRNAs) by identifying mRNAs with near complementarity. Complementary sites within predicted targets are conserved in rice. Of the 49 predicted targets, 34 are members of transcription factor gene families involved in developmental patterning or cell differentiation. The near-perfect complementarity between plant miRNAs and their targets suggests that many plant miRNAs act similarly to small interfering RNAs and direct mRNA cleavage. The targeting of developmental transcription factors suggests that many plant miRNAs function during cellular differentiation to clear key regulatory transcripts from daughter cell lineages.
journal_name
Celljournal_title
Cellauthors
Rhoades MW,Reinhart BJ,Lim LP,Burge CB,Bartel B,Bartel DPdoi
10.1016/s0092-8674(02)00863-2subject
Has Abstractpub_date
2002-08-23 00:00:00pages
513-20issue
4eissn
0092-8674issn
1097-4172pii
S0092867402008632journal_volume
110pub_type
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