Abstract:
:The origin of a low molecular weight virus-associated RNA (VA-RNA) was mapped by hybridization of VA-RNA to specific fragments of adenovirus type 2 DNA, obtained after cleavage with three different restriction endonucleases. VA-RNA was found to hybridize exculsively to the l-strand [strand with low buoyant density in CsCl when complexed with poly(U,G)] of a segment of the viral DNA which is located between positions 0.27 and 0.32 on the unit map of the adenovirus type 2 genome.
journal_name
Celljournal_title
Cellauthors
Pettersson U,Philipson Ldoi
10.1016/0092-8674(75)90066-5subject
Has Abstractpub_date
1975-09-01 00:00:00pages
1-4issue
1eissn
0092-8674issn
1097-4172pii
0092-8674(75)90066-5journal_volume
6pub_type
杂志文章相关文献
CELL文献大全abstract::Liquid-liquid phase separation (LLPS) mediates formation of membraneless condensates such as those associated with RNA processing, but the rules that dictate their assembly, substructure, and coexistence with other liquid-like compartments remain elusive. Here, we address the biophysical mechanism of this multiphase o...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2020.03.050
更新日期:2020-04-16 00:00:00
abstract::In budding yeast, septins are involved in the morphogenesis checkpoint and the DNA damage checkpoint, both of which regulate cell-cycle progression. In this issue of Cell, Kremer et al. (2007) link septins to DNA damage in mammalian cells by identifying a new signaling pathway that includes the adaptors SOCS7 and NCK....
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2007.08.022
更新日期:2007-09-07 00:00:00
abstract::The short chain aliphatic acid salts, butyrate and propionate, are effective inhibitors of histone deacetylation in chick oviduct at 2--5 mM; they also prevent the hormonal induction of the ovalbumin and transferrin genes. The less potent deacetylase inhibitor isobutyrate is correspondingly less effective in blocking ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(80)90357-8
更新日期:1980-11-01 00:00:00
abstract::The classical model for the activation of the nucleotide exchange factor Son of sevenless (SOS) involves its recruitment to the membrane, where it engages Ras. The recent discovery that Ras*GTP is an allosteric activator of SOS indicated that the regulation of SOS is more complex than originally envisaged. We now pres...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2004.10.005
更新日期:2004-10-29 00:00:00
abstract::DNA fragments containing the silencers that flank the mating type genes at HML alpha are shown to bind specifically to the nuclear scaffold of yeast. The scaffold proteins are solubilized with urea and then renatured to form a soluble extract which allows reconstitution of sequence-specific DNA loops. At the silent ma...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(89)90788-5
更新日期:1989-06-02 00:00:00
abstract::Cultured preadipose 3T3 cells are induced or enabled to undergo adipose conversion in the presence of an extract of pituitary gland. Adipogenic activity is found in standard growth hormone preparations derived from different species. Further purification of rat growth hormone by several methods does not remove its adi...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(82)90440-8
更新日期:1982-07-01 00:00:00
abstract::p25rum1 from the fission yeast S. pombe is shown to act as a specific in vitro inhibitor of the p34cdc2/p56cdc13 mitotic kinase. It is also shown that early G1 cells contain p25rum1, which associates with and inhibits the mitotic kinase, and maintains p56cdc13 mitotic B cyclin at a low level, ensuring that these cells...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(95)90215-5
更新日期:1995-12-15 00:00:00
abstract::To study the insertion of multispanning membrane proteins into the endoplasmic reticulum, we constructed novel proteins on the cDNA level by repeating, up to four times, the internal signal-anchor domain of the asialoglycoprotein receptor H1. Upon in vitro translation in the presence of microsomes, these polypeptides ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(88)90009-8
更新日期:1988-10-07 00:00:00
abstract::The distribution of microfilament bundles in cells was examined using antibodies to fibroblast myosin and indirect immunofluorescence microscopy. There is no correlation between the presence of bundles of microfilaments and normal growth control. A normal cell line (Balb/c 3T3) cultured on a poorly adhesive substratum...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(77)90024-1
更新日期:1977-03-01 00:00:00
abstract::The molecular nature of mutations arising in dysgenic hybrids between P and M Drosophila melanogaster strains has been investigated. Seven independent mutations at the white locus were examined, and these fell into two classes on the basis of their genetic and structural properties. The five mutations comprising the f...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(82)90462-7
更新日期:1982-07-01 00:00:00
abstract::The phenotype of the autosomal recessive mutation scat includes severe intermittent bleeding, depletion of platelets, and circulating anti-platelet antibodies. In this study, we have mapped the scat mutation to mouse chromosome 8 and shown that the immune component is a secondary consequence of the gene defect. Surpri...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(93)90301-6
更新日期:1993-07-16 00:00:00
abstract::The contribution of CD4+ T cells to protective or pathogenic immune responses to SARS-CoV-2 infection remains unknown. Here, we present single-cell transcriptomic analysis of >100,000 viral antigen-reactive CD4+ T cells from 40 COVID-19 patients. In hospitalized patients compared to non-hospitalized patients, we found...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2020.10.001
更新日期:2020-11-25 00:00:00
abstract::Immune homeostasis in the intestine involves complex interactions between microbial organisms and host cells. In this issue, Garrett et al. (2007) describe a communicable form of colitis that is induced by deficiency of the transcription factor T-bet in cells of the innate immune system. ...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2007.09.030
更新日期:2007-10-05 00:00:00
abstract::E. coli sigma 54 protein confers on promoters containing its recognition sequence the ability to be activated from distant DNA sites. Its functional domains include two leucine zipper motifs, an acidic region, and a glutamine-rich domain. Several domains were disrupted and the assembly of mutant transcription complexe...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(90)90269-k
更新日期:1990-09-07 00:00:00
abstract::In nematodes, a fraction of mRNAs contains a common 22 nucleotide 5' terminal spliced leader (SL) sequence derived by trans splicing. Here, we show that a cell-free extract prepared from developing embryos of the parasitic nematode Ascaris lumbricoides catalyzes accurate and efficient SL addition to a synthetic pre-mR...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(90)90689-c
更新日期:1990-06-29 00:00:00
abstract::Ubiquitin-conjugating enzyme variant (UEV) proteins resemble ubiquitin-conjugating enzymes (E2s) but lack the defining E2 active-site residue. The MMS2-encoded UEV protein has been genetically implicated in error-free postreplicative DNA repair in Saccharomyces cerevisiae. We show that Mms2p forms a specific heteromer...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(00)80575-9
更新日期:1999-03-05 00:00:00
abstract::Novel, approximately 90 bp intervening sequences (IVs) were discovered within the 23S rRNA genes of S. typhimurium and S. arizonae. These non-rRNA sequences are transcribed and then excised during rRNA maturation. The rRNA fragments that result from the excision of the extra sequences are not religated. This results i...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(90)90592-3
更新日期:1990-02-09 00:00:00
abstract::It is established that tumor cell-derived VEGF acts on endothelial cells to promote angiogenesis and tumor growth. Here, we demonstrate that in K5-SOS-dependent mouse skin tumors, autocrine VEGF is required for tumor cell proliferation in a cell-autonomous and angiogenesis-independent manner. VEGF is upregulated in SO...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2009.12.046
更新日期:2010-01-22 00:00:00
abstract::Homologous recombination in embryonal stem cells has been used to produce a fusion oncogene, thereby mimicking chromosomal translocations that frequently result in formation of tumor-specific fusion oncogenes in human malignancies. AF9 sequences were fused into the mouse Mll gene so that expression of the Mll-AF9 fusi...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(00)81269-6
更新日期:1996-06-14 00:00:00
abstract::Nutrition presents unanswered scientific questions of high public health importance. We envision model systems composed of interacting gastrointestinal and metabolic tissues derived from human embryonic stem cells, populated by gut microbiota. The culture will be embedded in 3D scaffolds, creating a controlled experim...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2015.02.039
更新日期:2015-03-26 00:00:00
abstract::The site on the HIV-1 gp120 glycoprotein that binds the CD4 receptor is recognized by broadly reactive antibodies, several of which neutralize over 90% of HIV-1 strains. To understand how antibodies achieve such neutralization, we isolated CD4-binding-site (CD4bs) antibodies and analyzed 16 co-crystal structures -8 de...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2015.05.007
更新日期:2015-06-04 00:00:00
abstract::The exchange of metabolites between the mitochondrial matrix and the cytosol depends on β-barrel channels in the outer membrane and α-helical carrier proteins in the inner membrane. The essential translocase of the inner membrane (TIM) chaperones escort these proteins through the intermembrane space, but the structura...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2018.10.039
更新日期:2018-11-15 00:00:00
abstract::Transcriptional regulation in the galactose regulon of yeast is determined by an interplay between a positive regulatory protein, GAL4, and a negative regulatory protein, GAL80. We show that derivatives of GAL4 missing as few as 28 carboxy-terminal amino acids are not responsive to GAL80 regulation, implying that the ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(87)90671-4
更新日期:1987-07-03 00:00:00
abstract::Monkey cells synthesizing SV40 large T antigen were lysed and the extracts immunoprecipitated with either monoclonal anti-T antibody or monoclonal antibody to p110-114, the product of the retinoblastoma susceptibility gene (Rb). T and p110-114 coprecipitated in each case, implying that the proteins are complexed with ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(88)90559-4
更新日期:1988-07-15 00:00:00
abstract::Post-translational modification of tubulin offers a mechanism for functional diversification of microtubules and regulation in a variety of physiological contexts. This SnapShot recaps the current state of understanding of tubulin posttranslational modifications and their functions in the regulation of biological proc...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2018.05.032
更新日期:2018-05-31 00:00:00
abstract::Neurons are frequently classified into distinct types on the basis of structural, physiological, or genetic attributes. To better constrain the definition of neuronal cell types, we characterized the transcriptomes and intrinsic physiological properties of over 4,200 mouse visual cortical GABAergic interneurons and re...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2020.09.057
更新日期:2020-11-12 00:00:00
abstract::The oligosaccharide-lipid which is the precursor of asparagine-linked oligosaccharides of eucaryotic glycoproteins is synthesized from sugar nucleotides in the endoplasmic reticulum. The transmembrane location of the assembly of this oligosaccharide-lipid has been studied in vitro in rat liver microsomes. Protease tre...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(80)90475-4
更新日期:1980-09-01 00:00:00
abstract::Using integrative genomic analysis of 360 metastatic castration-resistant prostate cancer (mCRPC) samples, we identified a novel subtype of prostate cancer typified by biallelic loss of CDK12 that is mutually exclusive with tumors driven by DNA repair deficiency, ETS fusions, and SPOP mutations. CDK12 loss is enriched...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2018.04.034
更新日期:2018-06-14 00:00:00
abstract::sigma(70) subunit is thought to be released from the core RNA polymerase (RNAP) upon the transition from initiation to elongation or shortly afterward. Here, we identify a population of RNAP from E. coli that retains sigma(70) throughout elongation. The relative amount of this population appears to depend on cellular ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(01)00461-5
更新日期:2001-08-24 00:00:00
abstract::22q11.2 microdeletions result in specific cognitive deficits and schizophrenia. Analysis of Df(16)A(+/-) mice, which model this microdeletion, revealed abnormalities in the formation of neuronal dendrites and spines, as well as altered brain microRNAs. Here, we show a drastic reduction of miR-185, which resides within...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2012.11.052
更新日期:2013-01-17 00:00:00